The Cullman Chemoprotection Center at Johns Hopkins University

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The Cullman Chemoprotection Center at Johns Hopkins University

Our goal is to identify novel opportunities for modifying human nutrition to develop protective agents to reduce the risk of a variety of chronic diseases.

Our research program embraces three strategic approaches:

Our goal is to identify novel opportunities for modifying human nutrition to develop protective agents that will reduce the risk of a variety of chronic and degenerative diseases, and prolong the period of wellness in our lives.

1. Fundamental studies of the molecular mechanisms of the signaling pathways that underlie disease development and prevention.

2. Study of dietary plants to capitalize on the extraordinary variety of their own chemoprotectors, and the mechanisms that plants have developed for protection against adverse environments.

3. Translation of information obtained from plants and molecular mechanisms to the clinic to achieve preservation of long-term health.

03/06/2020

New post added at Chemoprotection Center - Timing is EverythingOne of the primary mechanisms by which sulforaphane and other isothiocyanates exert their many beneficial effects on the body is through activation of nuclear erythroid-2-p45-related factor-2, or Nrf2, the master regulator of cellular defenses that protect against oxidative stress due to injury and inflammation. But other things activate Nrf2, too,

One of the primary mechanisms by which sulforaphane and other isothiocyanates exert their many beneficial effects on the body is through activation of nuclear erythroid-2-p45-related factor-2, or Nrf2, the master regulator of cellular defenses that protect against oxidative stress due to injury and....

09/09/2019

New post added at Chemoprotection Center - Chemoprotection News | September 2019Our Latest News
The CCC and Dr. Jed Fahey were featured in the media again this summer. Kate Krader of Bloomberg's Businessweek interviewed Dr. Fahey for this entertaining story about how a growing number of chefs are incorporating moringa into their recipes, and award-winning author Amanda Little interviewed him for her book, Fate

Our Latest News The CCC and Dr. Jed Fahey were featured in the media again this summer. Kate Krader of Bloomberg’s Businessweek interviewed Dr. Fahey for this entertaining story about how a growing number of chefs are incorporating moringa into their recipes, and award-winning author Amanda Little...

09/05/2019

New post added at Chemoprotection Center - Profiles in Chemoprotection: Part IIAlbena Dinkova-Kostova, PhD

Before Albena Dinkova-Kostova, Ph.D. trained to become a scientist, she trained as a seamstress.

She was 16 years old and living in Ruse, a large cosmopolitan city located on the south bank of the Danube River in northeastern Bulgaria, her home country. Just across the river lay Romania, connected by

Albena Dinkova-Kostova, PhD Before Albena Dinkova-Kostova, Ph.D. trained to become a scientist, she trained as a seamstress. She was 16 years old and living in Ruse, a large cosmopolitan city located on the south bank of the Danube River in northeastern Bulgaria, her home country. Just across the ri...

07/12/2019

New post added at Chemoprotection Center - New method for extracting the beneficial compounds in moringa identifiedA team of researchers from the Cullman Chemoprotection Center at Johns Hopkins University and the Universidad Nacional Autónoma de México led by Dr. Jed Fahey has developed a convenient and household-friendly method of extracting the beneficial compounds present in moringa, a tropical plant native to central and southern Asia. The

A team of researchers from the Cullman Chemoprotection Center at Johns Hopkins University and the Universidad Nacional Autónoma de México led by Dr. Jed Fahey has developed a convenient and household-friendly method of extracting the beneficial compounds present in moringa, a tropical plant native...

07/10/2019

New post added at Chemoprotection Center - Dose matters: New research demonstrates that sulforaphane from broccoli sprouts combats a cause of air pollution injury in a dose-dependent mannerAir pollution contains many toxic substances. One of these substances, benzene, is known to cause cancer in humans. A new study led by the Cullman Chemoprotection Center's scientific partner, Dr. Tom Kensler, found that sulforaphane provided in a broccoli sprout beverage increased the body's excretion of benzene in a dose-dependent

Air pollution contains many toxic substances. One of these substances, benzene, is known to cause cancer in humans. A new study led by the Cullman Chemoprotection Center’s scientific partner, Dr. Tom Kensler, found that sulforaphane provided in a broccoli sprout beverage increased the body’s exc...

07/06/2019

New post added at Chemoprotection Center - The plant enzyme that helps make broccoli so good for you survives the acid in your stomachNew research from a team of scientists led by Dr. Jed Fahey of the Cullman Chemoprotection Center investigated whether stomach acidity influences the activity of myrosinase, a type of enzyme. Myrosinase plays a role in the production of sulforaphane, a beneficial plant compound derived from broccoli and broccoli sprouts. The

New research from a team of scientists led by Dr. Jed Fahey of the Cullman Chemoprotection Center investigated whether stomach acidity influences the activity of myrosinase, a type of enzyme. Myrosinase plays a role in the production of sulforaphane, a beneficial plant compound derived from broccoli...

06/17/2019

New post added at Chemoprotection Center - Lewis B. Cullman, Generous Patron and Friend, Dies at 100Lewis B. Cullman (1919 - 2019)

The Cullman Chemoprotection Center’s longtime patron, Lewis B. Cullman, has passed away at the age of 100.

Lewis and his wife Dorothy (now deceased) were extraordinarily generous patrons of the fine arts, the humanities, and the sciences. Their connection to Johns Hopkins and to our work

Lewis B. Cullman (1919 – 2019) The Cullman Chemoprotection Center’s longtime patron, Lewis B. Cullman, has passed away at the age of 100. Lewis and his wife Dorothy (now deceased) were extraordinarily generous patrons of the fine arts, the humanities, and the sciences. Their connection to Johns ...

04/04/2019

New post added at Chemoprotection Center - Profiles in Chemoprotection, Part IThomas Wells Kensler, PhD
In a makeshift greenhouse comprised of steel growing racks, plastic tarps, and a portable electric space heater, …colleagues Jed Fahey and Tom Kensler grew broccoli sprouts for a clinical trial to gauge sulforaphane bioavailability in humans. It was the winter of 2003 in rural China, and bitterly

Thomas Wells Kensler, PhD In a makeshift greenhouse comprised of steel growing racks, plastic tarps, and a portable electric space heater, …colleagues Jed Fahey and Tom Kensler grew broccoli sprouts for a clinical trial to gauge sulforaphane bioavailability in humans. It was the winter of 2003 in ...

03/15/2019

New post added at Chemoprotection Center - The Passing of a Scientific GiantVery sad news: This past Sunday, a pioneer in the field of chemoprevention (protection against chronic disease) passed away on March 10th, at the age of 95. Paul Talalay, M.D. was the founding director of the Cullman Chemoprotection Center. He was a mentor and an inspiration to very many of

Very sad news: This past Sunday, a pioneer in the field of chemoprevention (protection against chronic disease) passed away on March 10th, at the age of 95. Paul Talalay, M.D. was the founding director of the Cullman Chemoprotection Center. He was a mentor and an inspiration to very many of us who n...

03/04/2019

New post added at Chemoprotection Center - Chemoprotection News | March 2019Our Latest News
Moringa and the Cullman Center's Dr. Jed Fahey are featured in this video from ATTN*, which has had more than 3 million views! Click on the image below to view.

*ATTN: is a relatively new media company that gets billions of “impressions” and about a billion monthly video views. They do original reporting

Our Latest News Moringa and the Cullman Center’s Dr. Jed Fahey are featured in this video from ATTN*, which has had more than 3 million views! Click on the image below to view. *ATTN: is a relatively new media company that gets billions of “impressions” and about a billion monthly video views....

03/04/2019

New post added at Chemoprotection Center - Chemoprotection News | March 2019Moringa and the Cullman Center's Dr. Jed Fahey are featured in this video from ATTN*, which has had more than 3 million views! Click on the image below to view.

*ATTN: is a relatively new media company that gets billions of “impressions” and about a billion monthly video views. They do original reporting and produce

Moringa and the Cullman Center’s Dr. Jed Fahey are featured in this video from ATTN*, which has had more than 3 million views! Click on the image below to view. *ATTN: is a relatively new media company that gets billions of “impressions” and about a billion monthly video views. They do origina...

01/14/2019

CCC founding director Paul Talalay and longtime colleague and collaborator Masayuki Yamamoto contributed to a recent study demonstrating that protected mice against lung injury by switching on genes involved in mitochondrial function, energy metabolism, and cardiovascular protection.

Nrf2 is essential to antioxidant response element (ARE)-mediated host defense. Sulforaphane (SFN) is a phytochemical antioxidant known to affect multi…

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