
07/18/2025
In men’s health, human chorionic gonadotropin (hCG) is often underutilized or misunderstood. While typically associated with fertility treatments, hCG plays a critical role in preserving testicular function, supporting endogenous testosterone production, and potentially contributing to neurosteroidogenesis via extragonadal LH receptors.
This comprehensive clinical review explores the molecular mechanisms behind hCG’s effects, its applications as both monotherapy and alongside testosterone replacement therapy, and important considerations regarding fertility preservation—highlighting why hCG should be viewed as a foundational tool in modern hormone optimization protocols.
For clinicians focused on functional and regenerative strategies, understanding how and when to use hCG effectively can help optimize outcomes for men concerned with both hormonal health and long-term fertility.
Read the full review below.
Learn how hCG supports testosterone, fertility, and testicular health at Apex Health & Wellness in Bellevue, WA—experts in men’s hormone therapy.