Seeking Health

11/04/2025

🖤 Black Friday Giveaway 🖤

It’s our biggest event of the year — and we’re kicking it off with something we never do.

🎉 One lucky winner will get a $200 shopping spree to use during our lowest prices of the year

🎁 Prize: $200 store credit to use during our Black Friday sale!

How to Enter:
1️⃣ Follow .Health
2️⃣ Tag 2+ friends in the comments 👯‍♀️
3️⃣ Earn BONUS Entries — the more you enter, the higher your chances!

💡 FB Friends: Want even more entries? Join on Instagram too!
⚡ BONUS Entries: Repost this to your story → 1 repost = +10 bonus points (unlimited!)

📊 Track your spot on our live leaderboard in stories 🔝
⏰ Ends Sunday, Nov 16 @ 11:59 PM PST

11/01/2025

Let's break it down…

🏦 Methyl groups: Created through methylation, constantly happening in the body (think MTHFR gene function).

💵 The PEMT gene: responsible for converting phosphatidylethanolamine into phosphatidylcholine (PC)—a process that burns through methyl groups.

Why does PEMT demand so many Methyl groups? 🤔

PEMT performs 3 sequential methylation reactions to produce PC. That means 3 SAMe molecules (your body’s universal methyl donor) are required ❗per molecule of PC made.

This makes the PEMT pathway a massive 💰methyl spender.

❓What does your PEMT control❓

1. 🫁 Bile fluidity and gallbladder function
Impaired PEMT activity = thick, sluggish bile, which increases risk of gallstones. In fact, PEMT dysfunction is directly linked to poor cholesterol export, gallstone formation, and poor estrogen clearance.

2. 🟡 Fat transport from the liver
When PC is low, fat accumulates in the liver—hello, fatty liver, poor detox, and gut health.

3. 🧫 Cell membrane integrity
Every cell in your body depends on healthy phospholipids to maintain structure and function.

Your Takeaway 🫵

Your MTHFR gene creates the methyl groups
Your PEMT, COMT, and HNMT (other genes) effect how they're spent.

💬 Comment “PEMT” to explore how to support this essential gene, why 🥇Optimal PC is our top supplement recommendation, and how it ties into gallbladder health and bile flow.

Want to learn more about how COMT, DAO and HNMT spend their methyl donors, let us know in the comments. 👀

10/30/2025

If histamine intolerance symptoms are dragging you down, one key question may lead to real progress:

Is it your gut—or your hormones—driving the overload? 🤔

🍴Gut-Driven Histamine Issues

Most histamine is produced and absorbed in the gut. If your DAO enzyme 🦠 (produced in your small intestine) is impaired, your ability to degrade dietary histamine plummets.

What can damage ⚠️ DAO and increase histamine absorption?

• SIBO or bacterial overgrowth
• Inflammation or food sensitivities (especially gluten and dairy)
• Nutrient deficiencies
• Mold, stress, or a microbiome imbalance

In the gut, DAO is king 👑. When it’s not working, histamine floods your system.

🩸 Hormone-Driven Histamine Surges

On the other hand, estrogen tells mast cells to release more histamine. And histamine, in turn, stimulates more estrogen—a vicious cycle 🔄.

This is why women 🙋‍♀️often experience:
• Worsened histamine symptoms mid-cycle (ovulation) and before menstruation
• PMS, migraines, endometriosis, or heavy periods when histamine is high

Hormone fluctuations during🤰 pregnancy also complicate things. In early pregnancy, DAO is low while histamine production (especially from the placenta) skyrockets. The result? Morning sickness is actually connected to histamine.

So Which One Is It?

💬 Comment “LOOP” to discover the functional order of healing — and how histamine connects to both estrogen and gut health issues. Start with your symptoms. We’ll help you identify the root cause and match you with the right supplement protocols for targeted support.

Want to know more about how pregnancy affects histamine?

Let us know in the comments 👀

Check out our Morning Sickness Guide: seekinghealth.com/pages/guides

10/27/2025

You’ve started supporting healthy estrogen balance and detox…

You’re using things like DIM, glutathione and/or calcium-D-glucarate. Maybe you’ve added liver-focused herbs/supplements or increased sauna time*…

But 🤨

Now, you're no better at all or even worse 😅

You’re still:
• Bloated
• Wired and tired
• Breaking out
• Dealing with brain fog
• Reacting to foods or supplements
• Or just not feeling better

Here’s what’s likely going on 👇

❗ Your clearance pathways weren’t ready.

Estrogen and other compounds must be processed and eliminated. If the elimination pathways are sluggish, anything your body mobilizes can get stuck—leading to a symptom spike.

⚠️ The Three Most Common Bottlenecks

➡ Methylation is blocked
Dirty MTHFR, COMT, or HNMT = slowed clearance of estrogen, neurotransmitters, and histamine in the brain.

➡ Sluggish/ Bile flow issues
Thick bile = poor hormone excretion and fat-soluble vitamin absorption (PEMT gene).

➡ Histamine can’t break down
DAO + HNMT pathways are overwhelmed = irritability, skin flares, PMS, sleep issues

💡 You don’t need more liver/hormone detox “support.” You need to open up the right clearance routes first—then your body can handle the rest.

📩 Comment “LOOP” to get a breakdown of where you are in the functional order of healing—especially if you’re dealing with estrogen imbalances, histamine issues, or gut-related hormone symptoms. You’ll learn where to start, why that step matters, and get targeted supplement support strategies for each layer of the healing process.

Find the best vitamins & supplements, best probiotics, formulated by Dr. Ben Lynch just for you. Shop with Seeking Health® today!

10/24/2025

Your COMT gene acts like a 🔉volume k**b for both dopamine and estrogen.

And depending on whether it's "fast" or "slow"…

It changes how your brain and body respond to stimulation, stress, and hormonal shifts.

Here’s the breakdown:👇

🧠😐 Fast COMT: Quick to Clear
• Lower dopamine tone
• Faster estrogen clearance

These individuals metabolize dopamine and estrogen more rapidly. That can mean:

🪫 Less dopamine in the brain → potentially lower drive, focus, and motivation
🌸 Lower estrogen levels → better estrogen clearance, especially under hormonal load or xenoestrogen exposure

Fast COMT types often handle❗stress and stimulation well, but may struggle with sustained focus or creativity.

🧠 😵‍💫 Slow COMT: Think Deep, Feel Deep
• Higher dopamine tone
• Slower estrogen methylation

With slow COMT, dopamine lingers longer in the brain.
Estrogen, however, also builds up due to slower clearance. That means:

🔋 Better motivation and cognitive flexibility
😰 But a higher risk of overstimulation, nervousness, and PMS or estrogen dominance symptoms

Slow COMT individuals often thrive in quieter, deep-thinking environments.

But ❗under stress or during hormone surges (like luteal phase or environmental toxin exposure), they can get overwhelmed.

Comment: COMT to learn more about how to optimize fast/slow COMT. Get mood support recommendations and better insight into whether or not you might have this gene variation.

10/22/2025

Your body actually uses 2 key genes to break down histamine

And they tell 2 very different stories…😳

Meet 🤝 DAO and HNMT

⚙️ DAO: The Gut Gatekeeper (more common)

DAO primarily works outside the cells,🍴 in the gut lining, placenta, and kidneys. Its job is to degrade extracellular histamine—especially the histamine from foods or microbial fermentation.

Symptoms of a sluggish DAO (dirty DAO):
• Bloating, food intolerances
• Skin itching, rashes, headaches
• Acid reflux or heartburn (often mistaken for excess acid)
• Unexplained irritable bowel issues
• Pregnancy nausea (DAO ramps up in 2nd trimester for a reason!)

Less dependent on methylation❗Can get “dirty” from gut inflammation, microbiome imbalance, or genetic variants.

🧠 HNMT: The Brain Regulator

HNMT handles🔬 intracellular histamine, primarily in the central nervous system. It requires methylation to function. Without it? Mental histamine builds.

Symptoms of poor HNMT activity (dirty HNMT):
• Restlessness, irritability
• Sleep issues, especially waking around 3–5am
• Headaches, vertigo
• Myoclonic twitches or mild tremors
• Mild respiratory symptoms: congestion
• If you have MTHFR (HNMT directly depends on methyl donors)

🙋‍♀️ Big Takeaway

Dirty MTHFR = Dirty HNMT = Chronic unease, sleep issues,
Dirty DAO = Dirty Gut = Food reactions, skin issues, pregnancy complications

Or both...

If you have symptoms in 🚩 both the gut and brain, your histamine imbalance may be bi-systemic. This means you likely need to support both DAO and HNMT pathways.

💬 Comment: “HISTA” to learn if your symptoms stem from DAO, HNMT, or both. We’ll explain why Histamine Nutrients🥇 is our top pick, get our guide, and learn how to optimize your protocol for deeper support.

Histamine intolerance supplements can support your body to have a healthy response to histamine.† Shop with Seeking Health® today.

10/20/2025

Slow COMT. Estrogen. Gut health.

Each is powerful on its own…

But together, they form a biochemical feedback loop that can make or break your body’s balance 😅

🔁 Here’s how the loop works 🔁:

→ COMT breaks down estrogen and dopamine.
If it’s “dirty/slow” (due to SNPs, stress, or poor methylation), estrogen builds up.

→ Estrogen slows bile flow and impairs histamine clearance.
This promotes gut inflammation and dysbiosis.

→ Gut health, especially bile flow from the gallbladder, is essential for clearing estrogen. Sluggish bile = higher estrogen, histamine issues, and SIBO risk.

This triangle feeds itself 🥲

It’s why you feel like you’re 🏃chasing symptoms—treating mood swings, histamine reactions, or digestive flares, while missing the root cause.

Start breaking the cycle:

💢 Struggling with estrogen imbalance (PMS, heavy periods, mood swings)
✔ Investigate your COMT gene (you might have it)
✔ Support methylation first (especially if you have MTHFR variants)

💢 Struggling more with gut issues (bloating, histamine sensitivity, sluggish digestion)
✔ Prioritize gallbladder health and bile flow
✔ Address histamine intolerance—support DAO and HNMT enzyme function
✔ THEN circle back to estrogen once gut and bile function improve

📌 Your takeaway:
Estrogen affects bile.
Bile affects the gut.
The gut affects how you clear estrogen.

This is the COMT-Gut-Estrogen Loop. 🫠

💬 Comment ” LOOP” to get deeper insights into how to determine where you are in the loop and which supplements could be helpful to your protocol.

Find the best vitamins & supplements, best probiotics, formulated by Dr. Ben Lynch just for you. Shop with Seeking Health® today!

10/17/2025

There’s not just one type of vitamin B12—

Your body uses 3 different kinds 👋

Each one helps with a different job. 🧰Think of them like different tools in a toolbox.

🔧 Hydroxo B12 (Hydroxocobalamin)

Acts as a storage form of B12. It binds well to carrier proteins in the blood, keeping B12 levels stable longer. Your body converts it to methyl- or adenosylcobalamin—only as needed.*

Ideal for those with sensitive methylation (MTHFR, COMT, etc.).*

⚡️Methyl B12 (Methylcobalamin)

This is the active methyl-donating form. It supports the MTR enzyme, which remethylates homocysteine into methionine—vital for methylation, mood, neurotransmitters, and detox.*

Too much too fast? Some may feel overstimulated.

🔋Adenosyl B12 (Adenosylcobalamin)

The mitochondrial form of B12.This one powers your cells—especially your mitochondria (the energy factories inside your cells). It helps you make energy and keeps your brain and nerves healthy.* (Methyl-free)

Low adenosyl? Think fatigue, poor coordination, and mitochondrial stress.

🫵 Your takeaway

Each B12 form plays a different biochemical role.

❗Try out and pay attention to which form benefits you most!

💬 Comment "METHYLATE" to explore our top methylated nutrients and B12 support combos.



*These statements have not been evaluated by the Food and Drug Administration (FDA). This product is not intended to diagnose, treat, cure, or prevent any disease.

10/15/2025

Your brain's "cleanup enzyme"—COMT—is responsible for breaking down stress-inducing neurotransmitters and excess estrogen.

When COMT is slow, that cleanup happens… slowly.

Cue: racing thoughts, poor focus, hormonal symptoms, and mood dysregulation.

🌱Lithium occurs naturally in water, soil, and some plants—but 🫤modern farming and water processing have greatly reduced our exposure. (So supplementing can be a good idea)

Lithium Orotate gently steps in to support:*

✔ Healthy transport of methylation nutrients (B12 + folate)
✔ Healthy response to overstimulation
✔ Calm cognition

What makes it special?

🧠 It’s subtle.

Because the doses are so small, lithium orotate doesn’t carry the same side effect profile or organ burden. It doesn’t require much routine blood monitoring.

💊For some, Lithium orotate shines when used alongside methylation nutrients like folate and B12.*

A small dose goes a long way, especially if you’re methylation-sensitive or prone to overstimulation.

💬 Comment “MINERAL to get our full guide on major signs you may benefit from low-dose lithium support—plus access to the complete Seeking Health cognition and mood support lineup.

❓More curious about slow COMT?

Comment: COMT (instead)👀


*These statements have not been evaluated by the Food and Drug Administration (FDA). This product is not intended to diagnose, treat, cure, or prevent any disease.

10/11/2025

When managing MTHFR variants, the focus is typically on methylation, homocysteine, and methylfolate but…

What’s often overlooked are two unsung cofactors in this pathway:
🥇Vitamin B2 (riboflavin) and ⭐ vitamin B6 (in its active form, P5P).

🚩If B2 is deficient:

MTHFR enzyme can’t do its job alone—it needs a tool called FAD to work. FAD is made from vitamin B2 (also called riboflavin).

• The MTHFR enzyme slows down, even if your genetics are optimal.
• Methylfolate supplementation won’t work efficiently.
• Homocysteine remains elevated despite “doing everything right.”

❗This is often misattributed to “needing more methylfolate,” when the issue is simply a dirty or undernourished MTHFR enzyme.

👋 Where B6 Comes In

Vitamin B6 supports the enzyme CBS, which clears homocysteine through the transsulfuration pathway.* If homocysteine isn’t cleared efficiently, methylation backs up.

Additionally, B6 is a cofactor for the conversion of ⏩ tryptophan to serotonin, dopamine production, and histamine metabolism, all of which can become dysregulated in those with MTHFR variants.*

🚩 B6 deficiency may manifest as:

• Irritability, mood swings, or low dopamine
• Increased histamine intolerance symptoms
• “Paradoxical” reactions to methylfolate

💬 Comment: “METHYLATE” to receive deeper insight into navigating MTHFR and methylation supplements. Whether or not you have an MTHFR variant, we’ll help you identify the right support for your unique methylation needs.


*These statements have not been evaluated by the Food and Drug Administration (FDA). This product is not intended to diagnose, treat, cure, or prevent any disease.

10/09/2025

Leucovorin is making headlines with the FDA in process of expanding its approved uses...

and for good reason.

This pharmaceutical of high-dose folinic acid is typically used in hospitals to:
✔ Rescue healthy cells after methotrexate
✔ Support neurological function in cerebral folate deficiency
✔ Compensate for impaired folate transport or metabolism

But here’s the part most people miss 👇

Folinic acid in supplement form (like lozenges or capsules)...

👏 is the same molecule—

just delivered in a much lower, more accessible dose for everyday use.

🤔 Why does folinic acid matter?

• Unlike folic acid (always avoid this form), it doesn’t require the DHFR enzyme to be activated

• Unlike methylfolate, it doesn’t overload your system with methyl groups

And most importantly…

Folinic acid can help reach your cells — even when folate receptors are blocked 🚧. It takes an alternate route, 🛣️ helping your brain and body access the folate they need.*

🚀 We offer a range of supplements featuring Folinic Acid (also listed as calcium folinate):

-Folinic acid lozenges
-Hydroxo B12 with Folinic Acid
-B Complex MF
-Optimal Prenatal MF
-Prenatal essentials MF
-Multivitamin One MF

💬 Comment “FOLINIC” below to get personalized details on each option and learn which one fits best into your wellness protocol.


*These statements have not been evaluated by the Food and Drug Administration (FDA). This product is not intended to diagnose, treat, cure, or prevent any disease.

10/08/2025

Estrogen isn’t just a hormone—it’s a water magnet.

High estrogen levels, especially around ovulation and the luteal phase, cause your body to retain sodium. This shifts fluid into tissues—leading to:

→ Puffy face
→ Bloating
→ Swollen hands or feet
→ Tender breasts

But the water retention is only part of the story. If estrogen isn't properly detoxified and eliminated, it continues to recirculate—worsening these symptoms and adding others: mood swings, PMS, heavy periods, fatigue, histamine sensitivity.

Estrogen detox happens in 3 phases, and if you're stuck in even one of them, symptoms build up fast.

👇🏼 Comment STUCK to uncover the 3 phases of estrogen detox, identify where you might be stuck, get targeted supplement support—and match symptoms to each phase.