04/14/2026
IUD MAKING YOU STRESSED? NEURAL CIRCUITS
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Levonorgestrel-intrauterine-devices (LNG-IUD) are one of the most used contraceptive methods worldwide.
Others:
intra-uterine device
non-hormonal IUDs
While several reviews exist on how LNG-IUDs impact physiology and gynaecological functions, this systematic review focuses on stress, mental health, quality of life, sexual functioning, and effects on brain architecture.
💡Concomitant inflammatory complications
The use of IUD often involves medical side effects such as abdominal complaints and bacterial and fungoid infections, as well as the concomitant inflammatory complications
Ex. pelvic inflammatory disease
Ex. Birth control Endometritis
LNG IUD also interferes with the hypothalamic-pituitary–gonadal axis (HPG axis), which is responsible for the production of endogenous hormones through positive and negative feedback loops.
** The GABA system has an essential role in the inhibition of the hypothalamic-pituitary-adrenal (HPA) axis. Its activation has both antianxiety and antidepressant effects
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