
06/10/2024
The Best Way to Administer Ketamine
Ketamine has been found to be a safe and effective treatment for depression when administered via more than half a dozen different methods or “routes”. Of these, intravenous (IV) ketamine — that is, injected into a vein — is the most common, and the bulk of depression research conducted with ketamine is with this route of administration. This is because it allows for very precise dosing since we know with perfect accuracy how much gets into your blood circulation and therefore your brain. In medical terminology, it has 100% bioavailability.
After IV, the most common are intranasal (IN) ketamine, followed by sublingual and oral ketamine. Effective figures drop off after Ketamine IV with IN (25-50%), sublingual (~20-30%), and oral (~10-20%) ketamine.
In addition to bioavailability, another important characteristic is how fast the effects kick in and how long they last. Vitality Medical Infusions offers the “Gold-Standard” of Ketamine with Intravenous (IV) Infusion.
Intravenous (IV) Infusion
Bioavailability: 100%
Onset of Effects: 10 minutes
Intranasal (IN)
Bioavailability: ~25-50%
Onset of Effects: 5 minutes
Sublingual
Bioavailability: ~20-30%
Onset of Effects: 10 minutes
Oral
Bioavailability: ~10-20%
Onset of Effects: 30 minutes
Call our experienced Ketamine medical team for an appointment.