Dr. Pooja Gidwani

Dr. Pooja Gidwani đź“ŤLA / NYC
🥼 Personalized Medicine
👩‍⚕️ Double Board-Certified Internal & Obesity Medicine
🩺 Weight Loss • Skin Care • Primary Care • Concierge Medicine

The most common thing I hear from patients in their late 30s: “I’m doing everything I used to, and it’s not working.”It’...
05/30/2026

The most common thing I hear from patients in their late 30s: “I’m doing everything I used to, and it’s not working.”

It’s not in your head. A 2025 Finnish study that followed people for three decades pinned the shift around 36, when the cost of the same habits starts to climb.

This is also the decade your body responds the fastest. In recent trials, biological age didn’t just slow, it moved backward on aging clocks.

And it goes beyond the basics. Diet, sleep, stress, and movement all matter — but a few levers punch above their weight:
→ Cardiorespiratory fitness — the single strongest predictor of how long you live (199 studies, ~21M people)
→ A Mediterranean-style diet, low in added sugar — a younger biological age in women tracked from their late 30s (JAMA Network Open, 2024)
→ Lower-body strength — leg power tracks with how young your brain stays
→ Vitamin D — protected telomeres by ~3 years of cellular aging over 4 years (VITAL, 2025)
→ Grip strength — predicts early death better than blood pressure

Cutting the vices still matters - that’s the half everyone knows. The other half, the one that actually moves biological age, is what you add. You need both.

Save this for the version of you ten years from now - and send it to someone in their 30s.

Educational, not medical advice.

05/28/2026

3 signs your GLP dose is too high.

1 - you feel your personality is going away. You don’t like things that you used to like before. You may not even have a libido anymore. This is called anhedonia

2- you’re losing more than once or 2 pounds a week. If so, you may be losing muscle. Remember, this is supposed to be slow and steady weight loss.

3- you’ve lost way too much of a desire to eat. You’re supposed to be feeling a decrease in food noise, but still nourishing your body. This is to ensure that you’re getting enough protein and fiber in, along with other nutrients to nourish your body.

if your doctor is going up on your GLP every month, this may be a bit of a red flag. Also a red flag to not track body composition.

05/27/2026

New longevity research suggests brain aging may begin decades earlier before symptoms present.

2026 studies are increasingly focusing on:
• nutrient optimization
• inflammation
• metabolic health
• and early prevention long before diagnosis

Higher vitamin D levels in midlife were linked to lower Alzheimer’s-related tau accumulation later.

Adults eating eggs 5+ times weekly showed significantly lower Alzheimer’s risk, likely related to nutrients like choline and lutein.

And lower active B12 levels despite “normal” labs were linked to more white matter damage and cognitive decline.

These interventions, if started early enough, may help prevent cognitive decline before symptoms ever begin.

Dementia prevention starts now.

Women in their 30s–40s are commonly told they can’t consider hormones because:• they’re “too young”• their labs are “nor...
05/26/2026

Women in their 30s–40s are commonly told they can’t consider hormones because:

• they’re “too young”
• their labs are “normal”
• they still have periods
• they have migraine with aura
• of breast cancer risk

Hormone therapy is nuanced. This doesn’t mean everyone with the above should take any form of HRT.

But timing, formulation, route, dose, risk factors, symptom burden, and patient selection all matter, and many women are being told no before a real discussion even happens.

05/26/2026

In women in their 30s-40s, cne of the biggest changes I see clinically is metabolic.

As estrogen declines, women may notice:
• more belly fat
• stronger cravings
• feeling puffier
• weight gain

This is part of why so many women feel like their body suddenly changed overnight.

Estrogen affects more than just reproductive health. It also affects:
• satiety signaling
• reward pathways
• insulin sensitivity
• body fat distribution
• inflammation
• muscle mass and recovery

For the right patient, GLP-1 medications may help improve several of these metabolic shifts during perimenopause, especially when combined with adequate protein, strength training, sleep, and broader hormonal/metabolic evaluation.

Share this with someone who is considering GLP-1s for perimenopause.

Women in their 30s-40s think they’ve suddenly become:too emotionaltoo anxioustoo overwhelmedtoo exhaustedtoo irritableto...
05/24/2026

Women in their 30s-40s think they’ve suddenly become:

too emotional
too anxious
too overwhelmed
too exhausted
too irritable
too antisocial
or just not themselves anymore.

Perimenopause influences the brain, nervous system, sleep, stress response, mood, energy, recovery, and emotional regulation, which is why it can feel mental and emotional long before women realize hormones may be involved.

Many women in their 30s and 40s are blaming themselves for symptoms nobody prepared them for.

Share this with another woman who may need to hear she’s not failing at life. Knowledge is power. 💕

05/23/2026

If you’re in you’re a woman in your 30s - 40s, do NOT ignore low libido.

Peptides can be an incredible tool for sexual health in midlife women.

Before I use something like PT-141, I look at the bigger picture first.

Because in women, “low libido” can sometimes actually be:

• vaginal dryness or discomfort
• low testosterone
• stress and elevated cortisol
• poor sleep and exhaustion
• feeling disconnected from your body
• metabolic or hormonal shifts

PT-141 can be a great tool in the right patient because it works on pathways involved in desire and arousal.

But if intimacy is painful, your hormones are depleted, or your nervous system is chronically overwhelmed, increasing desire alone may not fully solve the issue.

Send this to your girl who needs to take her libido seriously.

05/21/2026

I had this revelation when I got on my flight this morning. Perhaps I’m somewhat obsessed with the topic of modifiable risk factors for dementia, but suddenly the noise just sounded louder than it usually does.

Airplanes can reach 85 dB. Chronic exposure at that level contributes to noise-induced hearing loss. Think about that level of impact on long flights and with frequent travelers.

The Lancet Commission on Dementia Prevention, Intervention, and Care identified hearing loss as one of the strongest modifiable risk factors for dementia worldwide.

Side note - I always forget to download my Spotify playlist so I just wore earplugs and twiddled my fingers until there was a medical emergency on board (it was not related to a panic attack from not having WiFi)

I can’t have you guys suffer in silence so… I’m just a doctor without a solution to this one send help pls

05/15/2026

Oral GLP-1s or injectables? One of the biggest things we talked about here is that “oral vs injectable” isn’t really the full conversation as many make it out to be.

Oral GLP-1s currently use semaglutide, which targets the GLP-1 receptor only.

But injectable options now range from:
GLP-1 alone → to GLP-1/GIP → to GLP-1/GIP/glucagon receptor activity.

We’ve found that these have been more effective.

Similarly, if someone struggled significantly with injectable semaglutide, oral semaglutide may still feel very similar for them mechanistically.

What are your thoughts - orals or injectables? let us know in the comments!

Most people think of a DEXA scan as just a bone density test. I call it a financial audit of your health - muscle and bo...
09/15/2025

Most people think of a DEXA scan as just a bone density test. I call it a financial audit of your health - muscle and bone are your assets, and fat is your liability.

A DEXA scan really shows:
- Whether “normal” weight on the scale is hiding poor muscle-to-fat balance
- How much of your weight loss is muscle vs. fat (crucial for anyone on GLP-1s)
- Visceral fat levels, one of the strongest predictors of chronic disease

DEXA gives you what the scale can’t, and is ideal for tracking trends over time that strongly correlate to longevity.

You know EXACTLY who needs to hear this. Send this post to them.

From my recent feature in - thanks for writing this informative piece!

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