Dr.Kevin Obeng-Marnu,MD

05/02/2026

04/30/2026

USMLE 🇺🇸 STEP1- “Which Antibody Is Associated With an Increased Risk for Poor Renal Outcome?”..

A 58-year old patient with a history of mixed connective tissue disease presents to the dermatology clinic complaining of firm, indurated skin affecting the forearms and puffy fingers. The patient complains of the fingers turning white and blue in the cold with associated skin pain. A skin biopsy from the edge of a hyperpigmented plaque on the lateral forearm showed thickened collagen bundles within the reticular dermis and a perivascular and interstitial mononuclear cell infiltrate. The autoimmune panel was positive for ANA, U-1-RNP, and topoisomerase 1 antibodies.

Based on the history, clinical image, and biopsy results, which antibody is associated with an increased risk for poor renal outcome?

[A]. Centromere
[B]. Double-Stranded DNA 🧬(DsDNA)
[C]. Topoisomerase I (Scl-70)
[D]. RNA Polymerase III (RNA Pol III)

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