05/26/2024
History
A 36-year-old woman presents to her general practitioner (GP) complaining of spontaneous bruising mainly on her legs. The bruising has been noticeable over the last 4–6
weeks. She cannot remember any episodes of trauma. In addition her last two menstrual
periods have been abnormally heavy, and she has suffered a major nosebleed. She otherwise feels well, and is working full time as a secretary. There is no significant past medical history. She is married with one daughter aged 11 years. There is no family history of
a bleeding disorder. She is a non-smoker and drinks a small amount of alcohol socially.
Examination
On examination there are multiple areas of purpura on her legs and to a lesser extent on
her abdomen and arms. The purpuric lesions vary in colour from black–purple to yellow.
There are no signs of anaemia, but there are two bullae in the mouth and there is spontaneous bleeding from the gums. There are no retinal haemorrhages on funduscopy. Blood
pressure is 118/72 mmHg. Examination of the cardiovascular, respiratory and abdominal
systems is unremarkable.
What is the likely diagnosis?
Further manage and investigate this patient?