Great CBD Shop

Great CBD Shop In 2019, Great CBD Shop was established to become a trusted online shop for all things CBD. Our commi

02/27/2025
02/23/2025

H**p will be the future of all mankind, Or there won't be a future.

New Study: A Game Changer For Understanding Pain and Cannabis Cannabis has long been hailed for its pain-relieving prope...
02/20/2025

New Study: A Game Changer For Understanding Pain and Cannabis
Cannabis has long been hailed for its pain-relieving properties, but until now, skeptics have dismissed it as anecdotal or unproven. A groundbreaking Yale study changes that, confirming that CBD, CBG, and CBN directly inhibit Nav1.8, a key protein responsible for amplifying pain signals. This isn’t just theory—it’s molecular validation of what patients have reported for decades.
A recent Yale study confirms that CBD, CBG, and CBN directly inhibit Nav1.8, silencing excessive pain signals before they reach the brain. Of these, CBG emerged as the most potent inhibitor—suggesting it may be one of the most powerful cannabinoids for next-generation pain management.
We already know cannabis works through multiple pathways, and Nav1.8 inhibition is only part of the bigger picture;
- CB1 & CB2 receptors – The well-known, widely discussed endocannabinoid system interactions that help regulate pain, mood, and inflammation.
- TRPV1 receptors – Play a role in heat sensitivity and inflammatory pain responses (think of that burning sensation from spicy food—it’s related).
- GABA & serotonin modulation – Affect how nerves fire and how the brain processes pain signals.
This raises an important question: Is Nav1.8 inhibition a major driver of pain relief, or just one of many contributors to cannabis’s broader analgesic effects? That’s something future studies will need to untangle.
Yale Article: https://bit.ly/4hmILEu
PDF of the Study: https://bit.ly/3EmOpYM

02/03/2025

When you run outta w**d, you should be able to call 420 just like 911 & they'll find you a local plug.

02/03/2025

The wellness superstar taking the world by storm! 💥 Whether you’re looking for calm, relief, or vitality, CBD might just be your new best friend. Let’s dive into its jaw-dropping health benefits! 🚀

01/31/2025

Ma*****na should've been legalized at the same time as same sex-marriage, because it says in the bible a man who lies with another man shall be stoned.

01/27/2025

For Those Who Don't Smoke and still Support the Cannabis Thank You and Hit Like Comment and Share

01/06/2025

Why do you🤨
"I started smoking w**d because............"

01/05/2025

I smoke w**d before I eat to eat and then I smoke right after.

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OUR STORY

In 2019, Great CBD Shop was established to become a trusted online shop for all things CBD. Our commitment to customer service & satisfaction is what sets us apart from the rest. We saw a need for a quality and trusted site with ease of payment options, fast shipping, and above all great customer service.

Since the inception of the Farm Bill Act of 2018, Great CBD Shop has watched the landscape surround CBD change. As the need for alternative and holistic healing methods have become more and more mainstream, CBD has become the innovation that is life changing.

Every single product on our site has been lab tested for CBD purity and meets our gold standards. As advocates of helping people find what is best for them, we strive to educate consumers about the companies that we believe are bringing some of the best products to market. As industry leaders, we stay on top of technology that becomes available for all the newest delivery methods of CBD.

We start each day with our daily guiding premise which has and always will be: everyone should have access to CBD. We are proud to help consumers make an informed decision when choosing to enhance their life through the use of CBD. It is the success stories of the changes in our clients lives that help us do what we do each day.