Irene Ghobrial, MD

Irene Ghobrial, MD Physician-scientist in multiple myeloma at Dana-Farber/Brigham Womens Hematologic Oncology Treatment They have conducted over 10 phase I and II clinical trials.
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Dr. Ghobrial is a physician scientist who specializes in the field of Multiple Myeloma (MM) and Waldenström Macroglobulinemia (WM), specifically in the precursor conditions of Monoclonal Gammopathy of Undetermined Significance (MGUS) and Smoldering disease. She focuses particularly on the role of the malignant bone marrow niche in disease progression from early precursor conditions like MGUS/smold

ering MM to overt MM. She uses MM as a model of bone metastasis and dissemination. Dr. Ghobrial and her lab attempt to examine how MM can use a process of cell dissemination that is similar to cell trafficking of hematopoietic stem cell (HSCs) and cell metastasis in solid epithelial carcinomas. These studies can guide our understanding of the biological changes that occur during progression in MM. In addition, her laboratory research data has been rapidly translated to innovative investigator-initiated clinical trials. Their studies on MM cell trafficking have been translated to the first chemosensitization trials in patients with Multiple Myeloma. Dr. Ghobrial is the co-leader of the first consortium of clinical trials for blood cancers in collaboration with the Leukemia and Lymphoma Society to form the Blood Cancer Research Partnership (BCRP), a consortium for innovative clinical trials of 11 community oncology sites coordinated by Dana-Farber Cancer Institute. Moreover, she initiated a new clinic for Prevention of Progression in Blood Cancers where patients with precursor conditions such as MGUS, early Myelodysplastic Syndrome (MDS) and early Chronic Lymphocytic Leukemia (CLL) will be monitored prospectively for clonal evolution during disease progression. Clinical trials and research efforts are coordinated for patients seen in this clinic to develop therapeutic agents that can prevent/delay disease progression in these early malignant conditions.

Great work being done by my team!www.promisestudy.org
02/12/2020

Great work being done by my team!

www.promisestudy.org

This Black History Month, we are grateful for our Congresswoman, who has been a huge advocate for health equity.

More and more members of our community know someone who is affected by cancer. Multiple Myeloma (MM) is the most common blood cancer among people of African descent who are 2-3x more likely to develop MM within their lifetime. It is important to urge eligible family members to get screened for MM to ensure better health outcomes and improve our understanding of the mechanisms of this disease. To learn more about this free opportunity, please visit enroll.promisestudy.org

The Dana-Farber communications team is filming informational videos for our PCROWD study. Today, Tarek Mouhieddine, MD, ...
06/29/2018

The Dana-Farber communications team is filming informational videos for our PCROWD study. Today, Tarek Mouhieddine, MD, a research postdoctoral fellow at the Ghobrial Lab, talks about his research and the use of PCROWD samples for scientific discovery.

We are excited to invite medical practitioners in Egypt to attend the upcoming Hematology-Oncology Practice & Education ...
02/06/2018

We are excited to invite medical practitioners in Egypt to attend the upcoming Hematology-Oncology Practice & Education (HOPE) educational meeting.

HOPE 2018 will bring together physicians, physician scientists, and health care professionals from the United States, Europe, and Egypt who are working in the field of hematological malignancies.

It will cover the following topics:
Benign hematological disorders
Leukemia
Myelodysplastic syndromes & Myeloproliferative neoplasms Chronic Lymphocytic Leukemia
Multiple myeloma
Lymphoma
Nursing
Pharmacy
Clinical trials

Dates and Times:
February 23, 2018, 9 am - 4:30 pm
February 24, 2018, 9 am - 3:30 pm
Location: The Nile Ritz-Carlton, Cairo, Egypt

To get registered to this FREE event, please click on the following link: https://goo.gl/forms/UDKzKavAX2Hnjm8v2

Irene Ghobrial, MD briefly describes the research and recent discoveries that have been possible thanks to PCROWD sample...
12/21/2017

Irene Ghobrial, MD briefly describes the research and recent discoveries that have been possible thanks to PCROWD samples

Irene Ghobrial, MD discusses her team’s genomic analysis of patients with smoldering multiple myeloma (SMM), a precursor to full-blown blood cancer. The stud...

11/22/2017

Irene Ghobrial, MD, was recently awarded a Stand Up To Cancer (SU2C) Catalyst research grant. The grant will fund a phase 2 clinical trial for patients with high-risk smoldering multiple myeloma. You can read more about it here (http://bit.ly/2A0FBFj) under the title, "Catalyst grants widen scope of clinical research".

We climbed Kilimanjaro! Alex Detappe, MSc and Irene Ghobrial, MD, from the Ghobrial Lab, climbed Kilimanjaro to raise fu...
08/02/2017

We climbed Kilimanjaro! Alex Detappe, MSc and Irene Ghobrial, MD, from the Ghobrial Lab, climbed Kilimanjaro to raise funds for LLS.

06/19/2017

Salomon Manier, PhD and Irene Ghobrial, MD, researchers at Dana-Farber Cancer Institute, offer the first demonstration of a compound that can interfere with the five proteins that are critical to the survival of myeloma cells. http://bit.ly/2ssByLF

05/31/2017
05/17/2017

We reached 1000 patients on PCROWD today- Thank you every single patient for doing an amazing job

One of our PCROWD participants paid us a visit recently. Through her participation, she is contributing to advance resea...
05/03/2017

One of our PCROWD participants paid us a visit recently. Through her participation, she is contributing to advance research in precursor conditions!

Please join us on September 24 at the Jimmy Fund Walk. We have started a team called PCROWD and hope that you will becom...
05/03/2017

Please join us on September 24 at the Jimmy Fund Walk. We have started a team called PCROWD and hope that you will become a member or support our team. All the funds raised during the walk will support the PCROWD initiative under CPOP.

To join our team or give us your support, please visit the following link: http://www.jimmyfundwalk.org/2017/pcrowd

When registering as a walker, you will be prompted to decide what distance you will be walking. We will be doing the Half-Marathon distance starting in Wellesley and would love to have all of you join us there if you can. All walkers will receive a personalized Walk shirt and a medal.

If you can’t be in Boston on Walk day (September 24), registering as a Virtual Walker is a great way to stay involved with the event and raise money for CPOP! While there is no fundraising commitment tied to a Virtual Walker registration, if you raise the $300 minimum, you will be sent a Walk shirt and finishers medal!

Thank you for considering this and we hope to see you on September 24!

Take steps to conquer cancer! Register for the Jimmy Fund Walk on September 24, or make a gift!

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