Young-Pearse Lab

09/03/2025

Congratulations to Zach Augur, Garrett Fogo and the team on their publication, "Optineurin deficiency disrupts phosphorylated tau proteostasis and clusterin expression in human neurons" published today in Acta Neuropathologica Communications! This is the first of a set of three studies that encompass Zach's PhD thesis.
https://rdcu.be/eDMPB

08/25/2025

Best of luck today to Alex on her first day at Novartis! We will miss her greatly but look forward to seeing all of the fabulous things she accomplishes in her new scientific endeavors!

06/23/2025

I was deeply honored to receive the A. Clifford Barger Award for Excellence in Mentoring from Harvard Medical School this month. Thank you to all my past and present mentees and faculty who nominated me! I am incredibly fortunate to have the opportunity to mentor such wonderful trainees!

06/10/2025

We are excited about this new study from our lab in Cell Reports, led by Alex Lish and Nancy Ashour. It establishes a robust triple culture system of human iPSC-derived neurons, astrocytes and microglia, and reveals ways in which these cells affect the basal state of one another.
https://www.cell.com/cell-reports/fulltext/S2211-1247(25)00548-0

05/30/2025

A day late, but congratulations to our amazing graduates - Dr. Alex Lish, PhD;,Seohyun Kim, and Ellie Grogan! We are so proud of all you have accomplished and can't wait to see all the great things you'll do!

05/28/2025

Our fabulous graduate Alex Lish was profiled on the Harvard website today!

Over seven million Americans live with Alzheimer’s disease. Nearly 12 million more are involved in unpaid caregiving responsibilities for family members, friends, or other loved ones affected by Alzheimer’s or other types of dementia. Current therapies offer patients only modest relief. None cur...

05/10/2025

Thank you so much to Peter St. George-Hyslop, Li-Huei Tsai and Riqiang Yan for inviting me to present at the 3rd Targeting Therapy of Alzheimer’s and Related Neurodegenerative Disease Conference in Chania, Crete.

04/30/2025

We are excited to have our study published in Neuron today which provides a deep dive into the mechanisms underlying the role of Clusterin in the pathogenesis of Alzheimer’s disease. We show that protective CLU alleles enhance CLU upregulation in response to accumulated neuropathology, thereby dampening inflammatory signaling between microglia and astrocytes. This work was led by our fabulous graduate student Alex Lish, who will be receiving her PhD in May from Harvard University. A huge thank you to all of our amazing collaborators and funding partners including NIH and the Alzheimer’s Association.

03/25/2025

Our team had a great time and learned a lot at the funded investigators meeting for BD2 at a beautiful location. It was great to meet so many investigators dedicated to studying bipolar disorder, and to establish new collaborations.

03/03/2025

Congratulations to Dr. Alex Lish on a fabulous thesis and an excellent defense seminar!

12/23/2024

The elf has had a busy week in the lab - up to plenty of mischief.
Happy Holidays everyone!

12/14/2024

Thank you to everyone who came out to the lab holiday party and for putting up with my photo taking!