Young-Pearse Lab

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United States
Boston, MA
Young-Pearse Lab

Located at Harvard Medical School and Brigham and Women's Hospital

The Young-Pearse lab focuses on the identification of the mechanistic causes of neurodegenerative and developmental disorders of the nervous system, with the ultimate goal of identifying novel targets for therapeutic interventions for these diseases.

03/13/2026

It was great to attend the BD² Funded Investigators Meeting in Fort Lauderdale with colleagues. We had inspiring discussions, established new collaborations, and the had the opportunity to share our work. We are grateful to be part of a community working to help individuals with bipolar disorder thrive.

01/19/2026

We are excited to share our latest publication, " POU3F2 regulates canonical Wnt signalling via SOX13 and ADNP to expand the neural progenitor population" which was published in the journal Brain in December!
Lead author Courtney Benoit and Tracy discussed the paper on a recent podcast - the 33rd episode of "The Brain Podcast” – “Models matter: human-specific roles of POU3F2 and Wnt Signalling in neurodevelopment”.

https://open.spotify.com/episode/1sfNBP0JTiwC872EY6peGu?si=F2qKv3fLQCSSq0IKWt9SqQ&nd=1&dlsi=a13739d5e9de44ce

12/23/2025

Happy Holidays from the Young-Pearse lab!

11/17/2025

Welcome to the lab Masin Kearney!
Masin graduated from Emory in 2025 and is a now a technician who is working with both the research lab and the NeuroHub facility to develop stem cell derived neural cell cultures from humans across various ancestral backgrounds.

11/14/2025

Thank you to Jason Meyer and the team at Indiana University for including us in their 2nd Annual Indiana Stem Cell Research Symposium this week!

11/04/2025

Happy Halloween from the lab!

11/01/2025

Congratulations to Dr. Zachary Augur! He successfully defended his PhD this month. Over the years he has made many important contributions to our understanding of protein degradation pathways in human brain cells, which has culminated in three first author publications. We will miss him terribly but are excited to see all that he accomplishes in the future as he joins Bain and Company as a Consultant.

10/15/2025

We are excited to share our latest publication , "Genetic and proteomic analysis identifies BAG3 as an amyloid‑responsive regulator of neuronal proteostasis" which was published in Acta Neuropathologica this week! Congratulations to lead author Zach Augur, who will be defending his thesis later this week.

09/29/2025

Welcome to the lab Fasih Ahsan! Fasih is a genomic computational biologist who graduated from Harvard's BBS program and joined our lab in the fall of 2025. He is interested in using integrated computational approaches to help discover biological and clinical insights from large scale multi-omics data sets.

09/15/2025

Welcome to the lab Anna Cramer and Anna Curle! Team Annas are working on an exciting project using human induced pluripotent stem cells from diverse genetic backgrounds to investigate heterogeneity of disease and response to therapies in Alzheimer’s disease. Anna Curle is a postdoctoral fellow coming to us from the University of Cambridge, and is leading this effort. Anna Cramer is a research technician coming to us from the University of Washington who joined us in the summer.

09/09/2025

We have a strong and long standing relationship with the Rush Alzheimer's Disease Center and the powerful ROS and MAP cohorts that Dr. David Bennett established several decades ago. We are so grateful for our past and continued collaborative projects with them, and also for their strong support of the next generation of researchers aiming to end Alzheimer's disease and related disorders! Last spring, the RADC presented Dr. Sarah Heuer of our lab with the Martha Ondrey Postdoctoral Prize for her exciting research that leverages human cell models to elucidate how polygenic risk for Alzheimer's affects cellular state transitions and communications. Congratulations Sarah!

09/03/2025

Congratulations to Zach Augur, Garrett Fogo and the team on their publication, "Optineurin deficiency disrupts phosphorylated tau proteostasis and clusterin expression in human neurons" published today in Acta Neuropathologica Communications! This is the first of a set of three studies that encompass Zach's PhD thesis.
https://rdcu.be/eDMPB

Address

60
Boston, MA
02115

Telephone

(617) 525-5783

Website

http://youngpearselab.bwh.harvard.edu/, https://twitter.com/YoungPearseLab

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