MGH Neurology

10/10/2025

The Sean M. Healey & AMG Center for ALS is pleased to announce that the ALS Residence Initiative (ALSRI) was awarded the 2025 Gupta Family Endowed Prize for Innovation in ALS Care.

Dr. Merit Cudkowicz presented the prize to Steve Saling, CEO of ALSRI, and Barry Berman, CEO of Chelsea Jewish Lifecare, at the Northeast ALS Consortium (NEALS) Annual Meeting.

Read the announcement here: https://www.massgeneral.org/neurology/als/news/gupta-award-recipient-2025

10/10/2025

On the last day of the Northeast ALS Consortium (NEALS) Annual Meeting, the Healey & AMG Center for ALS will have two Platform Presentations.

▪️11:55 – Dr. James Berry will present, “Autologous Hybrid TREG/Th2 T Stem Cell Therapy (RAPA-501) is Feasible and Safe in Advanced-Stage ALS Patients With Severe Respiratory Insufficiency”
▪️12:27 – Dr. Merit Cudkowicz will present, “Phase 2b PARADIGM Results Demonstrate Safety, Clinical Signals, and Biomarker Engagement of PrimeC in ALS, Supporting Advancement to Phase 3”

Thank you for the past 3 days of collaboration and sharing updates on research!

10/09/2025

We’re kicking off the second day of the Northeast ALS Consortium (NEALS) Annual Meeting! We’ve got another busy day ahead, including two presentations from Healey & AMG Center team members.

▪️7:15am ET – Drs. Suma Babu and Sabrina Paganoni will participate in a presentation on “Learnings from Expanded Access Protocols (EAPs) in ALS.” Dr. Paganoni will share an update on the Trehalose EAP.
▪️3:20pm ET – Drs. Lori Chibnik, Eric Macklin, and Melanie Quintana will present at the session, “Stats Corner: Small Trials, Big Decisions in Early Phase ALS Research.”

Learn more about the meeting here: https://meeting.neals.org

10/08/2025

Today is the first day of the Northeast ALS Consortium (NEALS) Annual Meeting! The Healey & AMG Center for ALS team will provide multiple updates on initiatives. Below is today’s schedule.

▪️11:00am ET – Dr. Suma Babu will provide a Healey ALS MyMatch program update
▪️11:30am ET – Dr. Merit Cudkowicz will present on adaptations and new regimens in the HEALEY ALS Platform Trial
▪️11:45am ET – Dr. Sabrina Paganoni will help provide a LUMINA Study update
▪️12:00pm ET – Dr. James Berry will update us on the ALL ALS Study
▪️2:05pm ET – Dr. Christine Marques will share a science presentation on “Digoxin identified in phenotypic drug screen and validated as a modifier of dipeptide repeat-induced toxicity and TDP-43 pathology in ALS/FTD”

Learn more about the meeting here: https://meeting.neals.org

10/06/2025

What is ALS biomarker research?

In this video, Dr. James Berry answers some frequently asked questions about biomarkers and their importance in ALS research and clinical trials.

Check out the full video on the Healey & AMG Center Biorepository website!

🔗https://www.massgeneral.org/neurology/als/research/biorepository

10/04/2025

Tomorrow, Sunday, October 5, is The McCourt Foundation annual Neurological Symposium at the Marriott Boston Quincy (1000 Marriott Drive, Quincy, MA). View presentation topics and register here for this free event:

Join us for three free information sessions and hear from top doctors on progress in Multiple Sclerosis, Alzheimer's, and Parkinson’s research, treatment, and resource development. This is a completely free event for patients, caregivers and medical professionals.

10/03/2025

Dr. Suma Babu will share an update on the Healey ALS MyMatch program at the Northeast ALS Consortium (NEALS) Annual Meeting next week. She will discuss the structure and efficiency of the program, the use of genetic and biomarker data, and the first trial in the program.

10/03/2025

The ALS/MND Natural History Consortium has announced that Olga Uspenskaya-Cadoz, MD, PhD, will deliver the keynote lecture at the upcoming Annual Meeting in Clearwater, FL. The consortium, comprising leading academic medical centers from around the globe, is dedicated to advancing the understanding of ALS and related motor neuron diseases.

𝗞𝗲𝘆𝗻𝗼𝘁𝗲 𝗟𝗲𝗰𝘁𝘂𝗿𝗲 𝗗𝗲𝘁𝗮𝗶𝗹𝘀
𝗧𝗶𝘁𝗹𝗲: ALS Clinical Development in the Era of Novel Therapeutic Modalities: An Industry Perspective
𝗦𝗽𝗲𝗮𝗸𝗲𝗿: Olga Uspenskaya-Cadoz, CMO, VectorY Therapeutics
𝗗𝗮𝘁𝗲 & 𝗧𝗶𝗺𝗲: Monday, October 6, 1:45 PM
𝐋𝐨𝐜𝐚𝐭𝐢𝐨𝐧: Opal Sol Resort, Clearwater, FL

10/03/2025

In a recent interview, Tim Green shares his experience with ALS and Dr. Merit Cudkowicz discusses Green's significant contributions to ALS research. Green has raised over 10 million dollars for .

TackleALS Season 2 fundraising supports research in repair and regeneration. Learn more here: https://because.massgeneral.org/event/tackle-als-season-2/e540098

Watch the interview here: https://www.foxnews.com/video/6380363382112

Please join me in supporting ALS research at Massachusetts General Hospital through Tackle ALS at http://www.TackleALS.com

10/02/2025

At the Northeast ALS Consortium (NEALS) Annual Meeting next week, Dr. Sabrina Paganoni will share an update on the Trehalose Expanded Access Protocol (EAP).

Interested in learning more? Check out this paper: https://onlinelibrary.wiley.com/doi/10.1002/mus.70011

10/01/2025

Join MGB Neurology faculty at The McCourt Foundation annual Neurological Symposium this Sunday, October 5 at the Marriott Boston Quincy (1000 Marriott Drive, Quincy, MA). View presentation topics and register here for this free event: https://www.mccourtfoundation.org/event/neurological-symposium/

10:00–11:30 AM EST Multiple Sclerosis Session featuring: Rebecca Gillani, MD, PhD (Redefining Multiple Sclerosis Progression) and Jonathan Zurawski, MD (New Advances in Progressive MS)

12:00–1:30 PM EST Alzheimer’s Disease Session featuring: Valentina Perosa, MD, PhD (Healthy Vessels, Healthy Brain: What can you do against dementia) and John Dickson, MD, PhD (Real-World Clinical Experience with Anti-Amyloid Therapy for the Treatment of Alzheimer’s Disease)

2:00–3:30 PM EST Parkinson’s Disease Session featuring: Michael Schwarzschild, MD, PhD (Advances Toward the Prevention of Parkinson’s Disease), Vikram Khurana, MD, PhD (My Trial: Parkinson’s Disease, Stem Cells, and the Advent of Precision Clinical Trials), and Rich Krolewski, MD, PhD (Environmental Toxicants in PD)

Join us for three free information sessions and hear from top doctors on progress in Multiple Sclerosis, Alzheimer's, and Parkinson’s research, treatment, and resource development. This is a completely free event for patients, caregivers and medical professionals.

09/30/2025