05/11/2026
Congratulations to Vincent Malotaux and co-authors on our recent publication in the Journal of Prevention of Alzheimer’s Disease JPAD! 🌟
In this study of the Colombian PSEN1 E280A Alzheimer’s kindred, we show that blood biomarkers reveal a clear sequence of disease-related changes years before symptoms emerge. Aβ42/Aβ40 changed first, followed by p-tau217 and GFAP, which were also strongly associated with early cognitive decline. These findings highlight the potential of plasma biomarkers to track disease progression and monitor treatment response in autosomal-dominant Alzheimer’s disease. Check it out! 🧠
https://www.sciencedirect.com/science/article/pii/S2274580726001020?via%3Dihub