01/10/2026
Bullous pemphigoid is a rare autoimmune skin condition that mainly affects older adults. It happens when the immune system mistakenly attacks the layer of skin that helps hold the skin together, causing large, tense blisters filled with fluid. These blisters often appear on the arms, legs, abdomen, or groin and can be very itchy or uncomfortable.
Early symptoms may look like a rash, hives, or eczema before blisters develop, which is why it’s sometimes misdiagnosed at first. While bullous pemphigoid is not contagious, it does require medical treatment, often with topical or oral steroids and other medications to calm the immune response.
If you or a loved one has persistent itching, unusual rashes, or new blisters—especially later in life—don’t ignore it. Seeing a dermatologist early can help control symptoms, prevent infection, and improve quality of life.