12/05/2024
Cartilage restoration with MACI (Matrix-induced Autologus Chondrocyte Implantation)
Let me Translate that: cartilage cells from a non-weight bearing part of the knee are biopsied at the time of a knee arthroscopy and the chondrocytes or cartilage cells are grown in cell culture and implanted onto a collagen membrane. There's 500,000 or more cells per cubic centimeter. These are the patients' own cartilage cells, and they are implanted into the cartilage defects to fill in the defect with healthy cartilage.
The first image shows the cartilage defects with some scar tissue in the base of them. The second image shows the cartilage defects cleaned out with the calcified cartilage layer removed, so I'm down to healthy subchondral bone. The foil in the defect is a template for what I will use to cut the graft and size it perfectly for the defect, which is then glued into the defect with fibrin glue. This is basically the same stuff that forms a blood clot in our body at a site of bleeding. The final two images show the healthy graft glued into the defects, and over the course of weeks to months, the defects will fill in with healthy cartilage.
10-year follow-up data on this procedure in the United States reveals 92% of patients are satisfied with the pain relief they experience from this procedure and almost 80% of them return to their athletic level of competition or level of level of recreational activities before they had the cartilage injuries. So overall, a very successful and viable option to fill in cartilage defects