04/27/2025
Semaglutide is a medication that helps manage type 2 diabetes and obesity by mimicking a natural hormone called GLP-1, which your body releases after eating. Here’s how it works in simple terms:
What It Does
Blood Sugar Control:
When you eat, your intestines release GLP-1, which tells your pancreas to release insulin (a hormone that lowers blood sugar). Semaglutide acts like GLP-1, boosting insulin only when blood sugar is high, preventing dangerous drops.
It also blocks glucagon, a hormone that raises blood sugar by signaling your liver to release stored glucose.
Weight Loss:
Semaglutide slows digestion, making you feel full longer.
It reduces hunger by targeting brain areas that control appetite, helping people eat less.
Why It Lasts So Long
Natural GLP-1 breaks down quickly, but semaglutide is engineered to stick around:
A fatty acid chain attached to the molecule lets it bind to proteins in your blood, extending its activity for up to a week.
It’s modified to resist enzymes that normally break down GLP-1, like DPP-4.
How It’s Used
Injections: Given weekly.
