NEUROmergence

07/25/2025

𝐁𝐫𝐞𝐚𝐤𝐭𝐡𝐫𝐨𝐮𝐠𝐡 𝐑𝐞𝐯𝐞𝐫𝐬𝐞-𝐀𝐠𝐢𝐧𝐠 𝐒𝐮𝐩𝐩𝐥𝐞𝐦𝐞𝐧𝐭 𝐑𝐞𝐬𝐭𝐨𝐫𝐞𝐬 𝐌𝐞𝐧𝐭𝐚𝐥 𝐂𝐥𝐚𝐫𝐢𝐭𝐲 𝐢𝐧 𝐉𝐮𝐬𝐭 𝟏-𝟐 𝐖𝐞𝐞𝐤𝐬

🧠 If you're tired of feeling let down by supplements and treatments that promise results but deliver disappointment, you're not alone. At MDS LABS®, we've heard the skepticism loud and clear.

That's why we spent years reverse-engineering the proven senolytic effects of the breakthrough D+Q treatment. The result is 𝐍𝐄𝐔𝐑𝐎𝐦𝐞𝐫𝐠𝐞𝐧𝐜𝐞®, an FDA-compliant, plant-based breakthrough designed specifically for those dealing with:

✅ Chronic Brain Fog
✅ Cognitive Decline
✅ Long COV1D & Post-Viral Neuropathy
✅ Neurological Issues Post-Stroke

Unlike traditional vitamins and supplements that rarely deliver measurable outcomes, 𝐍𝐄𝐔𝐑𝐎𝐦𝐞𝐫𝐠𝐞𝐧𝐜𝐞® is backed by extensive peer-reviewed research—and, more importantly, by hundreds of satisfied customers who've finally experienced real relief.

✨ "For the first time in years, the brain fog lifted—I feel sharper, clearer, and myself again." – Real customer feedback

Try it Risk-Free: Noticeable results typically within 1-2 weeks after just two days of usage, or your money back. (Only 1 return out of thousands of sales!)

📚 Review our detailed 17-page research paper here:
https://www.mdslabs.shop/.../article5264-natural-dq-mimetic/

🔥 Special Offer: 50% OFF for a Limited Time Only (Now just $34.50)

Order now at: www.mdslabs.shop/product/neuromergence/

***midine

FORMULATED TO SUPPORT COGNITIVE REPAIR AND NEUROPROTECTION*BROAD SPECTRUM SENOLYTIC / SENOMORPHIC BLEND*DESIGNED TO TARGET SAME PATHWAYS AS GROUNDBREAKING D+Q SENOLYTIC*

03/30/2025

Tech Professionals at Risk – The Vision Crisis No One Talks About!

📢 A Silent Epidemic in the Tech World

From developers and data analysts to cybersecurity experts and digital creators, today’s workforce is more connected than ever—but at what cost? Studies show that prolonged screen exposure is leading to a surge in digital eye strain, fatigue, and long-term vision deterioration.

Enter Crystal Vision by MDS Labs, a cutting-edge eye health supplement designed specifically for those who live in front of screens. Backed by science, Crystal Vision combats blue light damage, oxidative stress, and screen-induced fatigue, helping tech professionals stay sharp, focused, and ahead of the curve.

🔬 The Tech Behind the Breakthrough:

✅ Lutein – Natural blue light filters to protect against digital strain
inflammation and eye fatigue
✅ Bilberry Extract – Supports night vision and enhances contrast sensitivity
✅ Eyebright, which is a natural source for quercetin, rutin, vanillin, apigenin, luteolin, kaempferol and more.
✅ Zinc, in combination with copper making it safe for daily intake

💡 Why It Matters: Whether you're coding for hours, analyzing data, or designing the next big thing, your eyes are your most valuable tool. Don’t let digital burnout blur your vision.

🔍 Early adopters in the tech space are already reporting sharper focus, reduced strain, and long-term eye health benefits.

⚡ Optimize your vision for the future. Stay sharp, stay focused, stay ahead.

https://www.mdslabs.shop/product/crystalvision/

Prolonged exposure to digital screens and artificial lighting has been associated with an increase in visual discomfort and ocular stress. "Crystal Vision" is a dietary supplement formulated with evidence-based ingredients, including Lutein, Bilberry, Eyebright, Vitamins C and E, Zinc, and Copper. T...

12/06/2024

🍂 FALL UPDATE FROM MDS LABS 🍂

Exciting updates are here at MDS Labs®! We're dedicated to providing innovative, transparent, and high-quality anti-aging solutions. Check out what’s new:

🔬 IL-11 Research Update

We have some good news concerning our N-of-1 trial to find the best natural promotor of IL-11 cytokine inhibition. It was recently found that inhibiting IL-11 might have profound anti-aging effects. You can read about the study here:

https://www.nature.com/articles/s41586-024-07701-9

In a process similar to what was used while developing NEUROmergence®, we've been experimenting with various natural compounds thought to inhibit IL-11. Utilizing Western blotting, one compound and one combination of two compounds were tested, each with three samples, over two 30-day periods (with 15 days in between test compounds). Our first set of tests utilized pure Osthole at 90mg/kg, and unfortunately, it exhibited little to no effect. These results were similar to another study, where it was found that the bioavailability of pure Osthole, after oral administration, was extremely low. Yet another study, on the medicinal properties of a traditional Chinese prescription known as Bushen Yizhi, it was discovered that Osthole's effectiveness was due to the combination with other herbs in the formulation, specifically Schisandrin B. So, for the second set of tests, we combined oral Schisandrin B and Osthole, and we were able to identify a much more noticeable impact on IL-11 levels over the 30 day period. This experiment has brought us much closer to developing a supplement that could potentially support the inhibition of IL-11 levels.*

Pure Osthole is not an FDA-compliant ingredient, and neither is Schisandrin B. So now our challenge is to develop one extract standardized to a high percentage of Osthole, most likely Cnidium monnieri or Angelica pubescens, to combine with another extract high in Schisadra B. Interestingly, Schisandra is not the only herb that contains Schisandra b. Finally, we would need to determine a ratio that is both safe and palatable for the supplement market, then retest for IL-11 inhibition, similar to what we did with NEUROmergence®, which involved testing its ability to promote inhibition of protein kinase enzymes that are also dasatinib targets. There is a possibility that we will instead offer an IL-11 support tincture, should it demonstrate favorable results, which leads us to our next update!

🌿 Traditional Chinese Medicine Tinctures

MDS Labs is now formulating premium tinctures inspired by Traditional Chinese Medicine (TCM) decoctions, combining time-honored formulas with cutting-edge solvent technology to preserve their active compounds. These potent elixirs deliver the same high-impact dosage found in classic herbal decoctions.

Our new line will include powerful formulations like Bushen-Yizi, Suan Zao Ren, Duzhong fang, Polygoni Multiflori Radix Praeparata, Bazi bushen, Bufei Yishen, Dendrobium, and Yokukansan— herbal blends that have often outperformed Western pharmaceuticals in clinical trials. Many of these have never been available for direct consumer purchase in any form.

What's truly remarkable about these decoctions is their multidimensional approach. Unlike single-target pharmaceuticals, these plant-based medicines contain hundreds of active compounds working together, to address multiple issues: inflammation, immunity, cognitive function, pain relief, and more. Western science is just beginning to appreciate this holistic approach—a concept known as the dCloud effect. Stay tuned for more updates on our journey to bring these remarkable TCM tinctures to your anti-aging routine!

💊 NEW Products Available Now!

- Berberine+ 800mg: Enhanced with L-leucine & olive oil.
- NEUROfuel®: A cognitive-support multivitamin with GABA, DHA, Bacopa, and more.
- Ginksentol: A potent blend of Ginkgo Biloba & Ginseng.
- Tumeric+: Featuring BioPerine® for optimized anti-inflammatory effects.
- Crystal Vision: A formula designed to support eye health that includes lutein, eyebright and zinc.

🌟 Don’t forget our Mushroom line! From Lion’s Mane to Reishi, our organic, standardized blends are perfect for whole-body support.

🧴 NEW Skincare Line
Introducing our first-ever skincare range! Vegan, scent-free, and science-backed.

Prices start at $21.50, and as always, shipping is FREE!

✨ NEW Website Look with Added Features
We’ve integrated Trustpilot for verified reviews! Share your feedback and enter to win a 3-month supply of NEUROmergence®.

Thank you for trusting us on your journey to better health and longevity. Questions? Email us at support@mdslabs.shop.

* Disclaimer: Please consult a physician before using our products if pregnant, nursing, or taking medications. These statements are not evaluated by the FDA.

www.mdslabs.shop

IL-11 is identified as a key regulator of ERK–AMPK–mTORC1 signalling, metabolism, inflammation and age-related disease and lifespan in mouse and human.

11/07/2024

𝗣𝗼𝘄𝗲𝗿𝗳𝘂𝗹 𝗡𝗲𝘄 𝗖𝗼𝗺𝗽𝗼𝘂𝗻𝗱 𝗰𝗮𝗻 𝗕𝗼𝗼𝘀𝘁 𝗡𝗔𝗗+ 𝗟𝗲𝘃𝗲𝗹𝘀 𝗶𝗻 𝗕𝗿𝗮𝗶𝗻, 𝗟𝗶𝘃𝗲𝗿, 𝗞𝗶𝗱𝗻𝗲𝘆, 𝗠𝘂𝘀𝗰𝗹𝗲, 𝗮𝗻𝗱 𝗛𝗲𝗮𝗿𝘁 𝗧𝗶𝘀𝘀𝘂𝗲, 𝗮𝗻𝗱 𝗙𝗼𝘂𝗻𝗱 𝘁𝗼 𝗯𝗲 𝟯𝟳% 𝗠𝗼𝗿𝗲 𝗣𝗼𝘄𝗲𝗿𝗳𝘂𝗹 𝘁𝗵𝗮𝗻 𝗡𝗠𝗡

Valencia, CA- MDS Labs has been researching a new NAD+ boosting compound that is thought to be up to 37% more effective than NMN.

NMNH (Reduced Nicotinamide Mononucleotide) is a promising anti-aging compound, functioning as a potent NAD+ (nicotinamide adenine dinucleotide) booster. Studies suggest NMNH can surpass both NR and NMN in efficacy due to its enhanced bioavailability. [1] However, it was shown that when NAD+ precursors like NMNH are combined with pterostilbene (NMNHPT), there is a synergistic effect that can increase NAD+ levels even further and with faster action. [2]

NAD+ plays a crucial role in cellular energy production, DNA repair, and metabolic processes, all of which tend to decline with age. Increasing NAD+ levels through NAD+ precursor supplementation may counteract age-related cellular degradation, potentially improving energy metabolism, reducing oxidative stress, and promoting longevity. [3]

Pterostilbene is a polyphenol structurally similar to resveratrol but demonstrates a higher level of bioavailability. It has antioxidant and anti-inflammatory properties, and is shown to improve cognitive function, support cardiovascular health, and reduce cellular damage linked to aging.* It is also known as a potent sirtuin activator (SIRT1). Sirtuins are a group of enzymes that help maintain cellular homeostasis and prevent metabolic decline. [4] When combined, NMNH and pterostilbene work together to optimize NAD+ levels and protect against age-related cognitive decline, supporting overall brain health and longevity.* MDS Labs® set out to create a superior NAD+ boosting supplement based on a data-driven approach. This product is our NMNH Boost+, which is a 3rd party tested, pure NMNH and pterostilbene complex in a vegan capsule.

Dr. David Sinclair’s original claims about NMN over five years ago on the Joe Rogan Experience marked the beginning of this supplementation trend. Since then, many additional studies have been completed. It is now believed that NMNH is the most bioavailable way to boost NAD+ levels.* This is important because it was found that both standard NMN and NR (Nicotinamide Riboside) are limited by their mild effects on the cellular NAD+ pool and necessitate higher doses. [5] The first randomized control trial of NMN revealed no significant change in muscle NAD concentration. [6] It was demonstrated that NMNH increases NAD+ levels to a much greater extent and faster than NMN or NR, and that it is metabolized through a different NRK and NAMPT-independent pathway in a murine model. [5] This study also noted that, unlike NMN or NR, NMNH causes a rapid and sustained NAD+ surge, which is accompanied by increased NAD+ levels in liver, kidney, muscle, brain, brown adipose tissue, and heart. [5] By taking the more bioavailable, reduced NMN (NMNH), we can potentially achieve much greater level of benefit.*

To read the full article with citations, and to purchase NMNH Boost+ with Pterostilbene, Please visit:

https://www.mdslabs.shop/product/nmnhboostplus/

* These products are not intended to diagnose, treat, cure, or prevent any disease.

11/02/2024

𝗨𝗻𝗹𝗼𝗰𝗸 𝘁𝗵𝗲 𝗣𝗼𝘄𝗲𝗿 𝗼𝗳 𝗦𝗲𝗻𝗻𝗮: 𝗠𝗼𝗿𝗲 𝗧𝗵𝗮𝗻 𝗝𝘂𝘀𝘁 𝗡𝗮𝘁𝘂𝗿𝗲'𝘀 𝗟𝗮𝘅𝗮𝘁𝗶𝘃𝗲! 𝗦𝗲𝗻𝗻𝗼𝘀𝗶𝗱𝗲 𝗕 𝗗𝗲𝗺𝗼𝗻𝘀𝘁𝗿𝗮𝘁𝗲𝘀 𝗣𝗼𝘄𝗲𝗿𝗳𝘂𝗹 𝗔𝗻𝘁𝗶-𝗮𝗴𝗶𝗻𝗴 𝗣𝗿𝗼𝗽𝗲𝗿𝘁𝗶𝗲𝘀 𝗯𝘆 𝗜𝗻𝗵𝗶𝗯𝗶𝘁𝗶𝗻𝗴 𝗣𝗗𝗚𝗙𝗥-β 𝗣𝗮𝘁𝗵𝘄𝗮𝘆𝘀

Senna is derived from the leaves and fruit of the senna plant (𝐶𝑎𝑠𝑠𝑖𝑎 𝑎𝑛𝑔𝑢𝑣𝑠𝑡𝑖𝑓𝑜𝑙𝑖𝑎), and is renowned for its powerful laxative properties. Its use dates back to 3150 BCE, and was even found in ancient Egyptian pottery jars. Its laxative properties come from compounds called sennosides, which stimulate the bowel lining to help relieve constipation- a common issue that tends to increase with age. Keeping your digestive system healthy is essential for overall well-being. However, senna has fascinating medicinal properties that far exceed that of just a laxative.

The two major active compounds in senna are sennoside A and sennoside B. They have both been shown to have significant gastroprotective activities by increasing prostaglandin E2, and have also demonstrated the ability to reduce gastric acid. [1]

The anti-aging properties of sennosides have been the subject of several recent studies. It has proven to be a potent inhibitor of PDGF and PDGFR-β, even when taken orally as a supplement. [3] PDGF stands for platelet-derived growth factor, and is a signaling pathway crucial in connective tissue development. PDGFR-β is a specific receptor for PDGF, and plays a major role in why we age.

When we are young, PDGFR-β lineage cells contribute to muscle regeneration. However, as we age, they switch roles, contributing to negative growth factors such as adipose tissue (associated with insulin resistance and muscle dysfunction), as well as fibrotic tissue, also known as fibrosis (scar tissue). When we reach our forties and beyond, excess PDGFR- β signaling reduces our body's ability to heal properly from injuries. [4]

PDGFR-β expression was found to contribute to age-related blood-brain barrier damage leading to dementia. Higher CSF PDGFR-β concentrations were found to increase CSF neuroinflammatory markers of glial activation and worse blood-brain barrier integrity. [5]

Premature aging syndrome is characterized by a lack of fatty tissue under the skin. This lack of fat, together with thin, wrinkled skin and veins visible beneath the skin, makes affected individuals look older than their biological age. This condition is a gene mutation that causes increased PDGFR-β. Several other diseases are also linked to increased PDGFR-β, including chronic eosinophilic leukemia and familial brain calcification. [6]

The potential to reduce excess PDGFR-β signaling just by taking a sennocide B supplement is a major breakthrough in anti-aging science. NEUROmergence® Senolytic by MDS Labs® is a new product designed to support increased longevity, and was specifically formulated with ingredients known to inhibit the same cellular pathways as the powerful D+Q senolytic treatment (a combination of Dasatinib and Quercetin), including PDGFR-β. Inhibiting these specific pathways has demonstrated the ability to slow dementia, reduce long-COVID-19 neuropathy, and even improve skin elasticity in clinical trials.

Sennocide B was included in this formulation to further align NEUROmergence as a D+Q mimetic supplement. PDGFR-β is one of the key pathways targeted by Dasatinib, which was first developed as a cancer fighting smart drug. NEUROmergence is the only senolytic supplement to demonstrate its effectiveness through Western blotting, which was a key metric during the development phase.

NEUROmergence is often considered the most powerful anti-aging supplement available without a prescription. It is praised for both its safety and tolerability compared to D+Q. It was formulated from compounds with well-known safety profiles, utilizing only FDA-compliant ingredients. You can order a one-month supply for $44.50 (with free shipping) from the link below:

https://www.mdslabs.shop/product/neuromergence/

MDS Lab®’s Sennocide B supplement is also available for purchase. This unique, full-spectrum senna extract contains a wide range of sennosides, however, like in NEUROmergence, it was standardized to 20% sennocide B. For more information and to see the full list of citations for this article, visit:

https://www.mdslabs.shop/product/mcs-labs-full-spectrum-senna-extract-15mg/

10/25/2024

🌿 Exciting News from MDS Labs! 🌿

We're thrilled to share a new development! MDS Labs is now crafting premium elixirs inspired by Traditional Chinese Medicine (TCM) decoctions, combining time-honored formulas with cutting-edge solvent technology to preserve their active compounds. These potent elixirs deliver the same high-impact dosage found in classic herbal decoctions—now available for you to enjoy at home!

Our new line includes powerful formulations like Bushen-Yizi, Suan Zao Ren, Duzhong fang, Polygoni Multiflori Radix Praeparata, Bazi bushen, Bufei Yishen, Dendrobium, Panax notoginseng, and Yokukansan—herbal blends that have often outperformed Western pharmaceuticals in clinical trials. 🌍 Many of these have never been available to purchase online until now.

What's truly remarkable about these TCM formulas is their multidimensional approach. Unlike single-target pharmaceuticals, these plant-based medicines contain hundreds of active compounds working together, addressing multiple health aspects: inflammation, immunity, cognitive function, pain relief, and more. Western science is just beginning to appreciate this holistic approach—a concept known as the dCloud effect.

Stay tuned for more updates on our journey to bring these remarkable TCM elixirs to your wellness routine! 🌱✨

10/17/2024

𝗗𝗲𝗲𝗽 𝗗𝗶𝘃𝗲 𝗶𝗻𝘁𝗼 𝗦𝗽𝗲𝗿𝗺𝗶𝗱𝗶𝗻𝗲: 𝗣𝗼𝘄𝗲𝗿𝗳𝘂𝗹 𝗔𝗻𝘁𝗶-𝗮𝗴𝗶𝗻𝗴 𝗕𝗲𝗻𝗲𝗳𝗶𝘁𝘀 𝗳𝗿𝗼𝗺 𝗦𝗽𝗲𝗿𝗺𝗶𝗱𝗶𝗻𝗲 𝗦𝘂𝗽𝗽𝗹𝗲𝗺𝗲𝗻𝘁𝗮𝘁𝗶𝗼𝗻 𝗢𝗻𝗹𝘆 𝗔𝗰𝗵𝗶𝗲𝘃𝗮𝗯𝗹𝗲 𝘄𝗶𝘁𝗵 𝗣𝘂𝗿𝗲 𝗦𝗽𝗲𝗿𝗺𝗶𝗱𝗶𝗻𝗲 𝗖𝗼𝗺𝗯𝗶𝗻𝗲𝗱 𝘄𝗶𝘁𝗵 𝗦𝘁𝗶𝗹𝗯𝗲𝗻𝗲𝘀

Spermidine, a naturally occurring polyamine found in foods such as aged cheese, mushrooms, soy products, and whole grains, has emerged as a promising compound in anti-aging research. Studies suggest it has the potential to extend lifespan and improve health as organisms age, particularly through its role in autophagy. In one study, s***midine extended the lifespan of mice by up to 25%. [1]

More recently, research on IL-11 inhibitors also indicated a similar 25% lifespan increase in mice. [2] This discovery created excitement across social media. However, it's important to note that less than 5% of treatments effective in mice studies translate successfully to humans. While animal studies provide valuable data, casual readers can be misled without proper scrutiny. In reality, only human clinical trials can be evaluated to understand a compound's true potential. Spermidine has been well-studied, and we have a lot of information available to us in order to paint a clear picture of the potential benefits.

In 1676, Antonie van Leeuwenhoek, the father of microscopy, was the first person to observe bacteria. A year later, he noticed his own s***m under the microscope, and in the following year, he saw crystals forming in semen. [3] Centuries later, this compound was identified as s***mine, a precursor to s***midine. Spermidine has since been recognized for its role in regulating cell growth and promoting autophagy, a key process for longevity.

Autophagy is the process by which cells break down and recycle their internal components. This essential process declines with age, leading to the accumulation of cellular waste, which can cause age-related diseases. Spermidine has been shown to enhance autophagy, potentially improving cellular function and longevity. [4] As we age, s***midine levels decline—by the time we reach our 50s, levels have decreased by about half. [5] Interestingly, certain non-aging mammals, such as naked mole rats, maintain high s***midine levels throughout their lives. This pattern has also been observed in human centenarians. [6]

Italian researchers found that by the time people reach their 70s, s***midine levels are about a third of what they were in middle age. However, people living into their 90s and beyond have been able to maintain youthful s***midine levels. It was found that declining levels can be replenished through a s***midine-rich diet or supplementation. However, most Spermidine supplements only contain wheat germ or wheat germ extract, and while this could work in theory, you would have to take the equivalent of ten grams of extract, or about twenty 500mg capsules to reach meaningful levels.

Pure s***midine, or Spermidine Trihydrochloride 99%, was found to only partially restore s***midine levels, with the dose reaching maximum benefit around 15-20mg. However, another study showed that effective Spermidine levels are achievable through supplementation, but only when combined with certain polyphenols, particularly stilbenes like resveratrol and pterostilbene (found in blueberries). [7] The synergy between this combination demonstrated effectiveness greater than either supplement alone. Pterostilbene has been demonstrated to be the most advantageous stilbene, due to its higher bioavailability, better membrane solubility, and stronger anti-inflammatory properties [8].

So to summarize, Spermidine supplementation with wheat germ extract is not practical. There is a partial benefit when using pure s***midine alone, but the maximum benefit comes from combining it with stilbenes, specifically pterostilbene.

Spermidine also shows promise for cognitive health. In one study, participants with mild dementia were given rolls enriched with wheat germ (versus wheat bran). The wheat germ group exhibited cognitive improvements that exceeded the results of all available anti-dementia treatments. [9]

Research also indicates that s***midine may support cardiovascular health. Studies show that regular intake of s***midine is linked to reduced blood pressure and a lower incidence of cardiovascular disease, likely due to its role in promoting healthy blood vessel function and improving metabolic parameters. [10]

NEUROmergence® by MDS Labs® is a phytochemical supplement designed to support longevity. It contains ingredients known to inhibit the same cellular pathways as the powerful D+Q senolytic treatment (a combination of Dasatinib and Quercetin). D+Q has demonstrated the ability to slow dementia, reduce Long-COVID-19 neuropathy, and improve skin elasticity.

NEUROmergence includes a full dose of pure Spermidine Trihydrochloride and Pterostilbene. Spermidine was incorporated into the formulation due to its ability to inhibit SRC family kinases (SRC, FYN, and LYN), as well as BCL-2 enzymes, key pathways also targeted by Dasatinib. NEUROmergence is the only senolytic supplement to demonstrate effectiveness utilizing Western blot assay, which was used to optimize its formula for maximum tyrosine kinase inhibition during the development phase.

NEUROmergence is available for $38.50 for a one-month supply below:
https://www.mdslabs.shop/product/neuromergence/

To see Citations for this article, more info on Spermidine Trihydrochloride individually visit:
https://www.mdslabs.shop/product/mds-labs-pure-s***midine/

For Pterostilbene information visit:
https://www.mdslabs.shop/product/mcs-labs-pure-pterostilbene-400mg/

***midine

Spermidine, a naturally occurring polyamine found in foods such as aged cheese, mushrooms, soy products, and whole grains, has emerged as a promising compound in anti-aging research. Studies suggest it has the potential to extend lifespan and improve health as organisms age, particularly through its...

09/27/2024

𝐌𝐃𝐒 𝐋𝐚𝐛𝐬® 𝐃𝐞𝐯𝐞𝐥𝐨𝐩𝐬 𝐍𝐄𝐔𝐑𝐎𝐦𝐞𝐫𝐠𝐞𝐧𝐜𝐞®, 𝐒𝐩𝐞𝐜𝐢𝐟𝐢𝐜𝐚𝐥𝐥𝐲 𝐓𝐚𝐫𝐠𝐞𝐭𝐢𝐧𝐠 𝐀𝐝𝐯𝐞𝐫𝐬𝐞 𝐊𝐢𝐧𝐚𝐬𝐞 𝐄𝐧𝐳𝐲𝐦𝐞𝐬, 𝐭𝐨 𝐒𝐮𝐩𝐩𝐨𝐫𝐭 𝐀𝐧𝐭𝐢-𝐚𝐠𝐢𝐧𝐠 𝐚𝐧𝐝 𝐂𝐨𝐠𝐧𝐢𝐭𝐢𝐯𝐞 𝐑𝐞𝐛𝐮𝐢𝐥𝐝𝐢𝐧𝐠

• Senolytic therapies are at the cutting edge of aging research, targeting and eliminating senescent cells and suppressing adverse pathways to potentially slow the aging process and improve tissue regeneration.

• The D+Q treatment, combining Dasatin1b and Quercetin, has shown promising results in reducing age-related physiological declines and may help treat Long-Cov1d neurological symptoms.

• Building on research in natural tyrosine kinase inhibitors, NEUROmergence® has been developed to target a broad spectrum of aging and disease-related pathways. It is offered as a phytochemical-based alternative to the D+Q treatment, that benefits from enhanced tolerability and effectiveness.

• MDS Labs® has recently launched the availability of NEUROmergence® to the general public, without the need for a prescription.

Valencia, CA – Senotherapeutic treatment is a rapidly emerging approach in the field of aging research and regenerative medicine. As we age, our bodies face a decline in immune system efficiency, leading to the accumulation of senescent cells. These cells impair the function of healthy cells, affecting our resilience to stress and illness, recovery from injuries, and even cognitive abilities. This cellular deterioration is a key contributor to numerous age-related diseases, including but not limited to cancer, diabetes, osteoporosis, cardiovascular diseases, strokes, Alzheimer’s and related dementias, and osteoarthritis. Senolytic treatments offer a promising solution by targeting and eliminating senescent cells, thereby fostering tissue regeneration and potentially decelerating the aging process and its associated diseases.

The D+Q treatment combines Dasatinib, a tyrosine kinase inhibitor, with Quercetin, a potent antioxidant flavonoid with neuroprotective qualities, leveraging their synergistic effects. Dasatinib induces apoptosis (cell death) in senescent cells by inhibiting the Src tyrosine kinase, while Quercetin does so by inhibiting the anti-apoptotic protein Bcl-xL (the “Philadelphia chromosome”).

Initially demonstrated to mitigate age-related physical dysfunction in mice, this groundbreaking combination has propelled a wave of human clinical trials. A notable study revealed that treatment with with D + Q significantly reduced age-related physiological declines in the human brain, and it was determined that the combination can offer therapeutic potential for COV1D-19 related neurological complications, marking a significant advancement in managing Long-Cov1d symptoms. The treatment is also showing promise in moderating the progression of Alzhe1mer’s disease.

A 2020 research finding demonstrated that isolated natural compounds, at a specific dose, could also act as tyrosine kinase inhibitors, targeting these specific pathways associated with aging and disease. This concept evolved into an expansive project to test various combinations of natural compounds for potential use in the development of a phytochemical counterpart to the D + Q treatment. This new research, which relied on AI drug discovery, and later verified by western blot assay, ultimately led to the creation of NEUROmergence®. Positioned as a natural supplement to support the inhibition of enzymes targeted by D + Q, NEUROmergence® was formulated to specifically support inhibition of BCR-Abl, SRC Family (SRC, FYN, LYN), c-kit (PI3K, AKT, JAK2, STAT3, MAPK), CSF1R, PDGFRβ, BCL-2, and CDK2 pathways, while also supporting activation of AMPK.

NEUROmergence® also includes 500mg of Quercetin to fully align the supplement as a counterpart to D + Q. The product has been praised as a safer alternative due to it’s enhanced tolerability and lack of side effects. This new and innovative formulation offers consumers the opportunity to experience an advanced anti-aging product unlike anything else on the market today. The product is now available for purchase without a prescription.

08/22/2024

𝗤𝘂𝗲𝗿𝗰𝗲𝘁𝗶𝗻, 𝘁𝗵𝗲 𝗡𝗮𝘁𝘂𝗿𝗮𝗹𝗹𝘆 𝗢𝗰𝗰𝘂𝗿𝗿𝗶𝗻𝗴 𝗙𝗹𝗮𝘃𝗼𝗻𝗼𝗶𝗱 𝗕𝗲𝗵𝗶𝗻𝗱 𝘁𝗵𝗲 𝗗+𝗤 𝗦𝗲𝗻𝗼𝗹𝘆𝘁𝗶𝗰 𝗧𝗿𝗲𝗮𝘁𝗺𝗲𝗻𝘁 𝗮𝗻𝗱 𝗣𝗼𝗽𝘂𝗹𝗮𝗿 𝗗+𝗤 𝗠𝗶𝗺𝗲𝘁𝗶𝗰 𝗙𝗼𝗿𝗺𝘂𝗹𝗮𝘁𝗶𝗼𝗻, 𝗡𝗘𝗨𝗥𝗢𝗺𝗲𝗿𝗴𝗲𝗻𝗰𝗲®, 𝗘𝘅𝗵𝗶𝗯𝗶𝘁𝘀 𝗯𝗼𝘁𝗵 𝗦𝗲𝗻𝗼𝗹𝘆𝘁𝗶𝗰 𝗮𝗻𝗱 𝗦𝗲𝗻𝗼𝗺𝗼𝗿𝗽𝗵𝗶𝗰 𝗣𝗿𝗼𝗽𝗲𝗿𝘁𝗶𝗲𝘀. 𝗟𝗲𝗮𝗿𝗻 𝗔𝗯𝗼𝘂𝘁 𝘁𝗵𝗲 𝗠𝗲𝗰𝗵𝗮𝗻𝗶𝘀𝗺𝘀 𝗕𝗲𝗵𝗶𝗻𝗱 𝘁𝗵𝗶𝘀 𝗨𝗻𝗶𝗾𝘂𝗲 𝗖𝗼𝗺𝗽𝗼𝘂𝗻𝗱 𝗮𝗻𝗱 𝗶𝘁𝘀 𝗥𝗼𝗹𝗲 𝗶𝗻 𝗙𝗼𝗿𝗺𝘂𝗹𝗮𝘁𝗶𝗻𝗴 𝗜𝗻𝗻𝗼𝘃𝗮𝘁𝗶𝘃𝗲 𝗡𝗲𝘄 𝗦𝗲𝗻𝗼𝘁𝗵𝗲𝗿𝗮𝗽𝗲𝘂𝘁𝗶𝗰 𝗧𝗿𝗲𝗮𝘁𝗺𝗲𝗻𝘁𝘀 𝘁𝗼 𝗜𝗺𝗽𝗿𝗼𝘃𝗲 𝗛𝗲𝗮𝗹𝘁𝗵𝘀𝗽𝗮𝗻 𝗮𝗻𝗱 𝗟𝗶𝗳𝗲𝘀𝗽𝗮𝗻

Quercetin is a naturally occurring flavonoid found in many fruits, vegetables, grains, and leaves, and is also found abundantly in onions, apples, berries, and tea. It's celebrated for its potent antioxidant properties, which combat oxidative stress and inflammation, key contributors to aging and chronic diseases. [1] Human and animal experiments have provided supportive evidence for the neuroprotective effects of quercetin, either against neurotoxic chemicals or in various models of neuronal injury and neurodegenerative diseases. Notably, quercetin is combined with the anti-cancer drug Dasatinib to formulate the groundbreaking D+Q senolytic treatment.

It is hypothesized that quercetin may act by having both a direct antioxidant effect, and might stimulate our cellular defenses against oxidative stress. It is thought to accomplish this by inducing the Nrf2-ARE and PON2 signaling pathways. Additionally, Surtuin (SIRT1) activation by quercetin has been shown to induce autophagy, the process by which the proteasome enzyme acts as the body's own clean-up crew, breaking down and destroying old, damaged, or abnormal cells, also known as senescent cells. [1]

As we get older, our immune system slows down, leading to an accumulation of these senescent cells. They can impair the function of healthy cells, affecting our resilience to stress and illness. Cellular senescence is a major driver of age-related chronic disease and geriatric syndromes, including cognitive decline. Senotherapeutics are a rapidly emerging treatment within the field of anti-aging research, designed to target and eliminate senescent cells, and support the regeneration of new tissue. Senotherapeutics are divided into two classes, senolytics and senomorphics. [2]

Senolytics can selectively target and kill senescent cells. The majority of known senolytics, for example, Dasatinib + Quercetin (D+Q), eliminate these cells by targeting critical enzymes associated with pro-survival and anti-apoptic (anti cell death) mechanisms, specifically the Bcl-2 signaling pathway. Senolytics have demonstrated the ability to alleviate many chronic ailments such as atherosclerosis and liver fibrosis, providing a measurable increase in healthspan. Several natural compounds, such as Fisetin, Curcumin, and Piperlogumine share these properties, through targeting various signaling pathways. [2]

Alternatively, senomorphics can reduce the inflammatory signaling secreted by damaged cells. They target different enzymes, including NF-kB, IL-1a, MAPK and others. Although senomorphics are less popular than senolytics, they may be a preferred method of intervention, as senescent cells are also implicated in processes such as wound healing and development. [2] Several senomorphic compounds, such as Rapamycin, which targets mTOR, Nrf2, and NF-kB, and Metformin, which also targets mTOR, and activates AMPK, are thought to have powerful anti-aging properties. Rapamycin is the only known compound that has demonstrated the ability to extend lifespan in all mammals. [3]

A fascinating aspect of Quercetin is that it shares both senolytic, and senomorphic properties. Its senomorphic action comes from its ability to activate proteasomes. These are barrel-shaped protein complexes that break down unwanted cells. When a protein is marked for destruction, enzymes patrol the cell and tag it with a chemical marker that the proteasome recognizes. The proteasome then unfolds the protein, stuffs it into a chamber, and cuts it into pieces that the cell can reuse to make new proteins. [4] Quercetin’s status as a senolytic comes from its ability to inhibit the SRC family kinase (SRC, FYN, LYN), BCL-2, PI3K isoform, and AKT kinase enzymes. AKT signaling pathways also play an important part in aging and anti-aging, and studies have shown that treatment with an AKT inhibitor can contribute greatly to increasing longevity. [5]

D+Q, the combination of Dastinib and Quercetin was first discovered from a hypothsesis-driven study. D+Q induces the reduction of abnormal cells by targeting specific cells called SCAPs, a pro-inflammatory type of stem cell released by senescent cells. [2] Early research demonstrated its ability to mitigate age-related dysfunction in mice. In 2019, the first human clinical trial revealed that D+Q can also significantly reduce age-related declines in humans. [6] The combination has also demonstrated therapeutic potential in managing long COVID-19 symptoms. Additional trials are underway, exploring D+Q's vast potential, including the moderation of Alzheimer's disease progression. [7]

The idea behind NEUROmergence®, a new senolytic formulation developed by MDS Labs®, was to create a natural, phytochemical mimetic of Dasatinb, to be combined with Quercetin for its powerful senotherapeutic properties. NEUROmergence® would be better tolerated, due to the known safety profile of natural compounds, especially in comparison to D+Q. Also, the formulation could be widely available to the general public without a prescription. Through Western blotting, Dasatinib’s predominant kinase enzyme targets were discovered as BCR-Abl, SRC Family (SRC, LCK, HCK, FYN, YES, FGR, BLK, LYN, and FRK), c-KIT (PI3K, AKT, JAK2, STAT3, MAPK), CSF1R, BCL-2, CDK2, and PDGFR (α and β). Once again, by utilizing Western blotting, seven natural compounds were then identified that can target a similar range of protein kinases, in addition to promoting AMPK activation. A 2015 study indicated that activation of AMPK itself can successfully delay aging. [8] Ultimately, the combination demonstrated significant inhibitory potential towards BCR-Abl, SRC Family (SRC, FYN, and LYN), c-KIT (PI3K, AKT, JAK2, STAT3, MAPK), CSF1R, Bcl-2, CDK2, and PDGFRβ pathways.

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