05/26/2026
Most providers think of iron as a linear equation....
Eat more iron (mostly animal-based), and the baby gets more iron...but pregnancy physiology is far more complicated, and elegant, than this.
👉🏼Outside of pregnancy, non-heme iron absorption is roughly 5-15%, but in pregnancy it skyrockets to nearly 70% in the third trimester (a 10-fold increase)
👉🏼Outside of pregnancy, heme iron absorption is roughly 35-40%, and in pregnancy, this doesn't change.
Here's where it really gets interesting...and where most prenatal nutrition stops...
Per the Handbook of Nutrition in Pregnancy (Humana Press), studies suggest that heme iron is taken up by enterocytes whole, intact, and transported directly to the placenta, where heme-specific transport proteins (highly expressed in the syncytiotrophoblast) take it up preferentially over non-heme iron. So the fetus preferentially receives intact heme iron.
While Mom's body prefers to use non-heme iron for maternal functions (thyroid, RBC/Hemoglobin, enzymes, etc.), storing the excess as ferritin.
The placental cells, as well, seem to rely more on non-heme (transferrin-bound Fe3) to fuel their function, sending excess to the baby. (The placenta is selfish and will prioritize its own iron needs over the baby and mom.)
When the baby is "full," meaning they have accumulated the ~350mg of iron they need before delivery, heme transport proteins in the placenta begin to downregulate, allowing more heme iron to accumulate in mom and going back to her storage needs...usually right around GA 36, causing her ferritin to rise again.
How does this change treatment?
If we are focusing solely on heme iron to fix iron deficiency, we may be helping baby...but not mom (at least not until baby is "full")
Remember... the same placental machinery that protects the fetus and regulates iron also poses a risk on the other side. Excess iron can accumulate in the placenta and cause damage, particularly heme iron (more on this later)