Broad Institute of MIT and Harvard

Broad Institute of MIT and Harvard This page aims to provide an interactive forum for the public to learn more about the science, culture and life of the Broad Institute. The Eli and Edythe L.

Please note that by participating, you agree to abide by some basic guidelines (www.broadinstitute.org/node/2408) Broad Institute of Harvard and MIT was launched in 2004 to empower this generation of creative scientists to transform medicine. The Broad Institute seeks to describe all the molecular components of life and their connections; discover the molecular basis of major human diseases; develop effective new approaches to diagnostics and therapeutics; and disseminate discoveries, tools, methods and data openly to the entire scientific community. Founded by MIT, Harvard and its affiliated hospitals, and the visionary Los Angeles philanthropists Eli and Edythe L. Broad, the Broad Institute includes faculty, professional staff and students from throughout the MIT and Harvard biomedical research communities and beyond, with collaborations spanning over a hundred private and public institutions in more than 40 countries worldwide.

Researchers from the Broad Institute and Massachusetts General Hospital have shown that a low-oxygen environment — simil...
08/06/2025

Researchers from the Broad Institute and Massachusetts General Hospital have shown that a low-oxygen environment — similar to the thin air found at Mount Everest base camp — can protect the brain and restore movement in mice with Parkinson’s-like disease.

The new research suggests that cellular dysfunction in Parkinson’s leads to the accumulation of excess oxygen molecules in the brain, which then fuel neurodegeneration — and that reducing oxygen intake could help prevent or even reverse Parkinson’s symptoms.

broad.io/Parkinsons-Oxygen

08/06/2025

Curious about the science behind eating disorders? Join Harvard T.H. Chan School of Public Health and Broad Institute of MIT and Harvard's research study and you’ll be entered into a raffle to win a $150 gift card just for participating. By helping us, you’re paving the way for improved treatments and real change for those impacted by eating disorders.

You do not need to have an eating disorder to participate.

Today we’re celebrating our latest winners from Oregon, New Mexico, and Texas. Will you be next? Get involved for a chance to win and know that you’re making a difference!

🔗https://redcap.partners.org/redcap/surveys/?s=HM9RH47YXRCT7KD4

By analyzing tens of thousands of genes, proteins, and protein modifications in hundreds of lung tumors, an internationa...
07/31/2025

By analyzing tens of thousands of genes, proteins, and protein modifications in hundreds of lung tumors, an international research team has uncovered new factors linked to poor outcomes in lung adenocarcinoma in both smokers and never-smokers, including a pattern of DNA damage and signatures of exposures to chemicals found in processed foods and cosmetics. Their findings could lead to better precision medicine strategies for this most common type of lung cancer.

🔗: broad.io/IGF2BP3

Many drug candidates fail in clinical trials due to unanticipated toxic effects that weren’t apparent in animal tests. N...
07/30/2025

Many drug candidates fail in clinical trials due to unanticipated toxic effects that weren’t apparent in animal tests. Now, a consortium co-led by Broad Institute scientists is building tools and datasets to reduce the need for animal testing in drug and agricultural chemical development. The Omics for Assessing Signatures for Integrated Safety (OASIS) consortium is using cell-based models and integrating cutting-edge cellular, transcriptomic, proteomic, and AI and machine learning technologies to better predict damaging effects of various compounds on the liver.

The consortium was launched in 2023 by Broad, the non-profit Health and Environmental Sciences Institute (HESI Global), and scientific partners spanning industry, government, academia, and other research institutes, and catalyzed by a grant from the Massachusetts Life Sciences Center. With experiments underway and more than 50 partner groups on board, the researchers are now producing and sharing datasets from their first rounds of experiments.

🔗: broad.io/OASIS

07/24/2025

The Broad Discovery Center, located at 415 Main Street in Cambridge, MA, offers a variety of free events and programs, including tours, interactive exhibits, and public talks.

One promising approach to treating infections with viruses like Ebola is to target host proteins essential to the virus....
07/24/2025

One promising approach to treating infections with viruses like Ebola is to target host proteins essential to the virus. Researchers at the Broad and the National Emerging Infectious Diseases Laboratories at Boston University used an image-based screening method, optical pooled screening, along with CRISPR perturbation to test the effects of silencing genes in millions of human cells infected with Ebola. They found multiple host proteins that, when suppressed, crippled the ability of Ebola virus to replicate, representing potential new drug targets for reducing disease severity in infected patients.

🔗: broad.io/Ebola-News-0724

David Liu, his team, and The Jackson Laboratory researchers, in a partnership with RARE Hope, have used prime editing, a...
07/21/2025

David Liu, his team, and The Jackson Laboratory researchers, in a partnership with RARE Hope, have used prime editing, a precise and versatile form of gene editing, to correct the root cause of a rare brain disorder called alternating hemiplegia of childhood (AHC) in mice. The team used a scalable approach to develop prime editing treatments that directly repaired five different AHC mutations. Treated mice had far fewer and less severe symptoms of AHC, and survived more than twice as long as untreated mice.

It’s the first time prime editing has been used to treat a neurological disease in animals, offering hope for treating people with AHC and other genetic brain disorders.

🔗: broad.io/Prime-AHC

Nina English Frost Hope for Annabel

We are thrilled to announce that Seth Klarman will become the next Chair of the Broad Institute Board of Directors, succ...
07/17/2025

We are thrilled to announce that Seth Klarman will become the next Chair of the Broad Institute Board of Directors, succeeding Eric Schmidt. We also welcome Aviv Regev as a new member of the Board.

broad.io/Klarman-Board

07/17/2025

Learn about your pet's behavior with Darwin's Ark and the Broad Discovery Center

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