Ragon Institute

Ragon Institute Harnessing the immune system to prevent and cure disease.

Meet Molly Bergeron, our Biosafety Officer! Molly works behind the scenes to ensure that scientists and researchers foll...
12/11/2025

Meet Molly Bergeron, our Biosafety Officer! Molly works behind the scenes to ensure that scientists and researchers follow proper protocols and understand complex biosafety regulations. Her job requires a lot of problem solving, but she loves a challenge and thrives at bridging the gap between regulators and scientists. She doesn’t just enforce rules – she works to make compliance easier, so researchers can focus on their work while knowing they’re in a safe environment. You will often hear her saying, “It depends…” because in biosafety, the answers are not always straightforward and finding the right solution requires thoughtful analysis and collaboration.
She tries to treat everyone with grace, knowing that she is just “one small part of someone else’s day.” Especially in her regulatory role, where she must enforce rules, Molly strives to approach everyone with compassion and understanding. She admits that she needs to work on giving herself some of this compassion, as her analytical mind can sometimes be self-critical. She reminds herself that it’s okay not to have all the answers right away and that everyone’s journey is different.
Having recently moved from Georgia to Boston with her husband and their dog, Arlo, Molly and her family are still adjusting to the New England weather. Thankfully, many of Molly’s hobbies, like knitting, crocheting, and fiber arts, keep her warm during these colder months. She is looking forward to warmer weather so she can enjoy volunteering as a grave photographer, a hobby that ties into her love of genealogy.
For Molly, strolling through graveyards and discovering weathered tombstones isn’t eerie—it’s an invitation to step into the past. She enjoys uncovering the history of those who have come before her and spends too much time wondering what their lives might have been like. To her, genealogical research is like a frame around a picture of history, each detail adding depth and meaning, helping to connect the past with the present. By studying her own family tree, Molly can see how more than just DNA links her to her ancestors, revealing deeper connections across generations.

Meet Eric Dang, PhD, the newest addition to the Ragon Institute faculty. A fungal immunologist joining us from NIH, Dr. ...
12/09/2025

Meet Eric Dang, PhD, the newest addition to the Ragon Institute faculty.

A fungal immunologist joining us from NIH, Dr. Dang studies how the billions of fungi we inhale and ingest every day shape our immune systems and overall health.

In this Q&A, he shares his journey from collegiate lacrosse player to leading researcher, why fungal infections are an underrecognized global health threat, and what drew him to Ragon's cross-disciplinary approach.

Read more here: https://ragoninstitute.org/2025/12/an-interview-with-eric-dang-phd-the-newest-ragon-faculty-member-exploring-how-everyday-fungi-shape-human-health/

📸: Dr. Dang and members of his lab

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Yesterday, the Ragon Institute and Tecnológico de Monterrey held our first annual joint symposium, "Metabolic Health and...
12/04/2025

Yesterday, the Ragon Institute and Tecnológico de Monterrey held our first annual joint symposium, "Metabolic Health and Immunity in Disease Pathogenesis."

Just one year after officially launching our partnership, researchers from both institutions gathered to share their latest findings on topics ranging from HIV vaccine development and tuberculosis progression to cardiac disease, autoimmunity, and the immune response to novel biomaterials.

The symposium also showcased joint research projects already underway, with collaborative presentations on HIV functional cure research, tuberculosis and metabolic dysfunction, lipids in CAR T cells, and autoantibody recognition in cardiac pathology.
Thank you to all the presenters and attendees who made this inaugural symposium a success, and to our organizing committee, Ragon faculty member Alison Ringel, PhD, and Associate Dean of Research at Tecnologico De Monterrey's School of Medicine, José Carlos Crispín, MD, PhD.

TecSalud

On World AIDS Day, we're proud to share a major step forward in HIV research.A new study published in Nature by Ragon fo...
12/01/2025

On World AIDS Day, we're proud to share a major step forward in HIV research.

A new study published in Nature by Ragon founding director Bruce D. Walker, MD, David Collins, PhD, and team reveals why some people with HIV achieve remission after antibody treatment—bringing us closer to a functional cure. The research identifies key immune characteristics in elite controllers, rare individuals who naturally suppress HIV without medication, that predict successful viral control after treatment.

This breakthrough builds on decades of vital contributions from research participants whose generosity and partnership make scientific progress possible.

Read more about the findings: https://ragoninstitute.org/2025/12/walker-lab-researchers-identify-why-some-people-with-hiv-achieve-remission-after-antibody-treatment/

We are proud to share that the Ragon Institute's building at 600 Main Street has been recognized with a 2025 Architectur...
11/25/2025

We are proud to share that the Ragon Institute's building at 600 Main Street has been recognized with a 2025 Architectural Record Award (Honorable Mention).

Designed by our partners at Payette, the 323,000-square-foot facility in Kendall Square has been our new home for over a year and was created to foster collaboration, support cutting-edge infectious disease research, and provide welcoming, accessible spaces for our community.

Architectural Record is a leading US-based monthly magazine dedicated to architecture and interior design. At over 130 years in print, it is widely recognized as a key record of evolving debates in architectural practice, history, and criticism, showcasing noteworthy projects from around the world.

Read more about the award and design: https://payette.com/designalways/the-ragon-institute-honored-with-2025-architectural-record-award/

11/19/2025

On November 12, the Ragon Institute welcomed signatories of the Gates–Buffett Giving Pledge for a learning session on how philanthropy can accelerate discovery in immunology and global health. This short video, created for the event, offers an overview of our work and the impact of partnering with visionary donors to advance bold scientific ideas.

The Ragon Institute brings together scientists and clinicians from Mass General Brigham, MIT, and Harvard to study the immune system and turn breakthroughs into new vaccines, diagnostics, and treatments for diseases that affect people around the world. By uniting cutting-edge research with a deep commitment to global health equity, we aim to prevent and cure human disease and improve lives far beyond our walls.

Learn more about the Ragon Institute at ragoninstitute.org

The Ragon community is as active beyond the lab as it is within it!Three members of the Gaiha Lab—faculty member Gaurav ...
11/13/2025

The Ragon community is as active beyond the lab as it is within it!

Three members of the Gaiha Lab—faculty member Gaurav Gaiha, MD, DPhil, postdoctoral fellow Matt Getz, and Harvard Virology PhD student Alton Gayton—ran the BAA Half Marathon last weekend.

Gaiha and Gayton also completed the full BAA Distance Medley, a year-long series including the 5K, 10K, and Half Marathon. Both finished in the top ten for their age groups, with Gayton taking an impressive second place in his age group.

We’re proud to celebrate their dedication, teamwork, and the spirit of the Ragon community both inside and outside the lab.

At the recent 2025 Warren Alpert Foundation Prize Symposium, Ragon Institute founding director Bruce Walker, MD, joined ...
11/11/2025

At the recent 2025 Warren Alpert Foundation Prize Symposium, Ragon Institute founding director Bruce Walker, MD, joined leading scientists as a speaker at the event to honor groundbreaking advances in HIV treatment and prevention. The symposium recognized Tomas Cihlar, John Link, and Wesley Sundquist for their pioneering work on lenacapavir and the next chapter in HIV research.

Dr. Walker also led a special conversation with Bill Gates, Chair of the Gates Foundation, discussing the global fight against HIV and the future of equitable access to prevention and care. Collaboration and scientific innovation continue to move us closer to ending the HIV epidemic.

Watch Dr. Walker's full conversation with Gates here: https://youtu.be/wjgzsXAlzFA?si=oCB24MTGdaFFhM5z

(Photos by Gretchen Ertl Photography)

A new study led by the Bryson Lab at the Ragon Institute and published in Science Translational Medicine lays out a prac...
11/07/2025

A new study led by the Bryson Lab at the Ragon Institute and published in Science Translational Medicine lays out a practical roadmap for making better tuberculosis (TB) vaccines by starting from what infected human immune cells actually show to CD4 T cells. Bryan Bryson, PhD, a core member of the Ragon Institute and an associate professor of biological engineering at MIT, was one of the authors.

Put together, the study gives TB researchers two key things: a set of TB antigens that human cells are known to actually present and that are common across many TB strains, and a proven mRNA method to make human cells present them well. That directly addresses one of the current bottlenecks in building a better TB vaccine and reflects significant progress in fighting the disease.

Read more: https://ragoninstitute.org/2025/11/bryson-lab-study-defines-tb-vaccine-targets-directly-from-infected-human-cells-and-shows-how-to-deliver-them-with-mrna/

Triet Doan is a research technician in the Barczak Lab at the Ragon Institute, where he studies Mycobacterium tuberculos...
11/04/2025

Triet Doan is a research technician in the Barczak Lab at the Ragon Institute, where he studies Mycobacterium tuberculosis. His research focuses on the host-pathogen interface, exploring how immune cells—specifically macrophages—fight back against tuberculosis infection. For Triet, research isn’t just about science—it’s about visual storytelling. The microscopy images he carefully crafts don’t just reveal cellular interactions; to him, they are “not just data, but works of art.”

Triet’s passion for infectious disease research is fueled by a larger goal: to become a physician-researcher—someone who not only advances scientific discoveries but also applies them directly to patient care.

Outside the lab, Triet was a former Broadway show choir member, and now is part of the Ragon choir while also teaching himself acoustic guitar. He loves all kinds of music, from slow R&B to hip-hop rap, and is always keeping up with interesting new releases!

Triet radiates positivity. Raised to value empathy and human connection, he puts this into practice as a volunteer for Samaritans’ national lifeline, providing a compassionate ear to those in need.

"That’s something I practice every day—just listening to people. Everyone has a story, and sometimes they just need someone to validate them and help them realize what’s going on."

With his compassion, resilience, and drive, there’s no doubt that Triet is on his way to making a profound impact—both in science and in the lives of others.

A large international study, published in Nature Microbiology and led by the Kwon Lab at the Ragon Institute and the Xav...
10/30/2025

A large international study, published in Nature Microbiology and led by the Kwon Lab at the Ragon Institute and the Xavier Lab at the Broad Institute, shows that HIV infection and common antiretroviral drugs change the gut microbiome in distinct, geography-dependent ways.

These changes notably may help explain ongoing inflammation and heart-disease risk in people living with HIV. The team analyzed whole-metagenome data from 327 people with HIV and 260 controls in Uganda, Botswana, and the United States.

Read more: https://ragoninstitute.org/2025/10/kwon-and-xavier-labs-map-how-hiv-and-antiretroviral-treatment-alter-the-gut-microbiome-across-continents/

A new study co-led by the Batista Lab at the Ragon Institute and Scripps/IAVI shows that a single mRNA-based vaccine mix...
10/28/2025

A new study co-led by the Batista Lab at the Ragon Institute and Scripps/IAVI shows that a single mRNA-based vaccine mix can jump-start the early steps toward several promising HIV-fighting antibodies at the same time. Because HIV is extremely diverse, a successful vaccine would likely need to train the immune system along multiple routes, not just one.

The team tested “germline-targeting” mRNA vaccine ingredients which are molecules designed to wake up the rare B cells that can later mature into broadly neutralizing antibodies. In mouse models built to mimic how rare these cells are in people, the mRNA mix activated starting cells for four well-studied HIV antibody targets on the virus’s Envelope protein.

Read more: https://ragoninstitute.org/2025/10/ragon-scripps-collaboration-shows-single-mrna-shot-can-start-several-hiv-blocking-antibody-paths-at-once/

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