XRpro Sciences, Inc.

08/28/2015

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Icagen offers industry-leading scientific expertise and comprehensive services for ion channel and...

08/27/2015

A recent study published in the 'Proceedings of the National Academy of Sciences' revealed how nanochannels select potassium ions. Find out more: http://bit.ly/1PTw3u6

08/26/2015

A new study published by Nature Neuroscience found ion channel blockers may prove to be useful in cancer therapy. Learn more: http://bit.ly/1K2HSPK

Drugs called ion channel blockers, which are commonly used to treat cardiac, neurological, and psychiatric disorders, might prove useful in cancer therapy, according to research findings in fruit flies and mice by UC San Francisco scientists ...

08/26/2015

Please note: we will be providing news and updates on our brand new Icagen Facebook profile: http://on.fb.me/1JW65Hx

Icagen offers industry-leading scientific expertise and comprehensive services for ion channel and...

08/25/2015

A recent study by the Virginia Commonwealth University and University of Richmond explores one key difference between human and sponge ion channels that researchers now believe developed around the same time the first animals evolved: http://bit.ly/1PQhkA5

08/13/2015

Icagen to offer pharmaceutical and biotechnology companies expert ion channel & transporter services: http://bit.ly/1IRcm0A

CAMBRIDGE, Mass., and DURHAM, N.C., July 2, 2015 /PRNewswire/ -- XRpro Sciences, Inc. today announced its ...

07/27/2015

Icagen will offer industry‐leading scientific expertise and comprehensive access to technologies for ion channel and transporter drug discovery and development. Click to learn more: http://bit.ly/1JD24BQ

07/24/2015

Researchers from Northwestern Medicine report findings in PNAS to understand how a mutation in a channel activator protein, STIM1, prevents calcium release-activated channels (CRAC) from opening, resulting in a lack of activation of T-cells and other immune cells. Specifically, they discovered that the structural alteration caused by the mutation prevents STIM1 from binding to the channel and activating it. http://bit.ly/1JD1eFb

Patients with mutations in specialized calcium ion channels called calcium release-activated channels (CRAC) suffer from a severe immunodeficiency syndrome.

06/25/2015

During this year's Ion Channel Retreat, XRpro's Dr. Nathan Zahler will give a talk highlighting proof of concept data for SLC transporters including new data on zinc transporters. For more information regarding the 2015 Ion Channel Retreat please visit their website. http://bit.ly/1JYa8R7

July 7th – 9th, 2015 | Vancouver BC, Canada. Location: Hyatt Regency Vancouver 655 Burrard Street, Vancouver, British Columbia, Canada, V6C 2R7.

06/23/2015

Mutations in the Piezo1 gene, a mechanosensitive ion channel, have been linked to the blood disease, xerocytosis, that leads to hemolytic anemia. A pair of recent papers have reported the discovery of a synthetic small molecule, Yoda 1, that can activate Piezo 1 in the absence of mechanical stimulation, which in turn caused red cell shrinking via secondary activation of other ion channels. http://bit.ly/1JYyU3J

Researchers have discovered a synthetic small molecule that activates a mechanosensitive ion channel involved in a blood disorder.

06/19/2015

Researchers investigated the role of miR-224 as a regulator of SLC4A4 and CFTR, the key buffering ion transporters in modulating enamel mineralization. Overexpression of miR-224 down-regulated SLC4A4 and CFTR expression via binding to 3’ UTR of SLC4A4 and CFTR mRNA, thereby inhibiting protein translation. http://bit.ly/1G48WqH

ABSTRACT Enamel mineralization is accompanied by releasing protons into the extracellular matrix, which is buffered to regulate pH value in local microenvironment.

06/19/2015

This recent review discusses the distinct role of voltage-gated ion channels (VGIC) in cancer cell proliferation and possible therapeutic potential of VIGC pharmacological manipulation. Although VGIC are well known for controlling rapid bioelectrical signaling, studies have demonstrated that these classes of proteins can also contribute significantly to cell mitotic biochemical signaling, cell cycle progression, as well as cell volume regulation, all functions critical for cancer cell proliferation. http://bit.ly/1JYtkhv

Changes of the electrical charges across the surface cell membrane are absolutely necessary to maintain cellular homeostasis in physiological as well as in pathological conditions.

06/18/2015

According to a recently released study, innovation in the biotech and pharmaceutical industries outpaced technology sectors overall between 2009 and last year. Learn more: http://bit.ly/1JYeEPI

06/05/2015

"New structural insights into the gating movements of CFTR. Nice commentary on the recent findings of Chaves and
Gadsby (2015) that offer structural insight into the normal workings of cystic fibrosis transmembrane conductance regulator (CFTR) channel which may have implications on the development of compounds to treat cystic fibrosis. http://bit.ly/1HMjHka"

In Chicago’s Field Museum of Natural History, there is
an exhibit highlighting the evolutionary relationships
between carnivorans. Glass cases lining two of the four
walls of this room display specimens of feliforms, cats
and their relatives.

06/04/2015

Researchers have identified how calcium ion-channels in cerebral arteries determine the specific role each channel plays in helping to control blood flow to the brain. Learn more: http://bit.ly/1J6eF3D

Researchers have performed the first human-based study to identify calcium channels in cerebral arteries and determine the distinct role each channel plays in helping control blood flow to the brai...

06/03/2015

A recent editorial “Ion Channels and Mental Illness: Exploring etiology and pathophysiology in major psychiatric disorders” in Frontiers in Genetics presents three original research manuscripts and five literature reviews that Dr. Askland believes advance our understanding of the role of ion channels in the etiology and pathogenesis of psychiatric disease. http://bit.ly/1J6el4J

This Research Topic, Ion Channels and Mental Illness: Exploring etiology and pathophysiology in major psychiatric disorders, presents three original research manuscripts and five literature reviews...

06/02/2015

A recent study of individuals suffering from Chronic Fatigue Syndrome found 13 single nucleotide polymorphisms (SNPs) significantly associated with CFS. Nine of the SNPs were found in the gene encoding TRPM3. A pilot study of over 200 individuals suggests an association between transient receptor potential (TRP) ion channels and chronic fatigue syndrome (CFS). A total of 240 single nucleotide polymorphisms (SNPs) with 21 mammalian TRP ion channel genes were examined. Significant association between thirteen SNPs and CFS were detected, nine of which were located within the gene encoding TRPM3. http://bit.ly/1J6d65v

Examination of Single Nucleotide Polymorphisms (SNPs) in Transient Receptor Potential (TRP) Ion Channels in Chronic Fatigue Syndrome Patients

06/01/2015

A new study on agonist activation of TRPM2 ion channels exemplifies how a rigorous biophysical approach can provide definitive answers. Tamara Rosenbaum provides a nice commentary on the recent work of Toth et al.(doi: 10.1085/jgp.201511377) Read commentary: http://bit.ly/1J6cpJD

The conclusions we draw regarding the molecular mechanisms that govern ion channel activation rely on both careful experimental design and meticulous analysis and interpretation of the data.

05/29/2015

PI(4,5)P2 was thought to be involved in regulating a number of ion channels and transporters, but the mechanism of action was unclear. A recent paper in J Gen Physiol identified a point mutation (R721A) in TRPV1 that inverted its selectivity between PI(4,5)P2 and PI(4)P binding. The mutation localized to the region of TRPV1 that interacts directly with the phosphoinositide providing a potential means of PI(4,5)P2 regulation. http://1.usa.gov/1J69xfQ

Although PI(4,5)P2 is believed to play an essential role in regulating the activity of numerous ion channels and transporters, the mechanisms by which it does so are unknown.

05/28/2015

A recent review published in April 2015 summarizes the current findings regarding the role of TRP proteins in the development of cardiovascular disease, diabetes mellitus as well as diabetic complications, and tumorigenesis and presents TRP proteins as targets of potential diagnostic and therapeutic strategies. http://1.usa.gov/1J6b85m

Transient Receptor Potential (TRP) channel proteins are a diverse family of proteins that are expressed in many organisms, tissues and cell types.

05/26/2015

XRpro Sciences, Inc. announced today that the Company will present at the 2015 Marcum MicroCap Conference on Thursday, May 28, 2015 in New York City at the Grand Hyatt Hotel. The Company's presentation by Richie Cunningham, CEO, and Timothy Tyson, Chairman is scheduled to begin at 1:30 p.m ET. More information can be found here: http://bit.ly/1Ky8sPS

CAMBRIDGE, Mass., May 26, 2015 /PRNewswire/ -- XRpro Sciences, Inc., a provider of a unique platform for drug discovery and development services which features high throughput transporter and ion channel assays for the pharmaceutical industry.

05/12/2015

Ion channels are holes in the cell membrane which allow electrically charged particles ('ions') to move from one side of the cell membrane to the other. An Oxford University research team was recently able to catch snapshots of an ion channel in action, helping explain how neurons respond to a variety of stimuli, from drugs to touch. http://bit.ly/1EkUPeF

The electrical impulse that powers the workings of the brain and the heart begins with charged particles passing through cellular structures known as ion channels.

05/11/2015

A recent market report predicts increased spending on new technologies that are transforming the entire process in an effort to identify superior drug candidates. In North America alone, 2013 sales topped $15 billion and are projected to rise to $32 billion by 2019. The report states “These [new] technologies – in combination with genomics, proteomics, cell-based assays and so forth – are expected to transform the drug discovery process, which is the most time- and cost-consuming step in the entire drug development lifecycle.” Read more: http://bit.ly/1ISkge4

According to the new report from BCC Research, the global market for drug discovery technologies is expected to grow at a compound annual growth rate (CAGR) ...

05/08/2015

XRpro® technology enables cell-based assay of nonelectrogenic transporters such as cation chloride (CCC) and K-Cl (KCC) family transporters which conventional electrophysiology cannot measure.

05/07/2015

High throughput, cell-based Ion Channel and Transporter assays using standard cell biology without the need for radiolabels or fluorophores using label-free XRpro® technology.

05/06/2015

XRpro Sciences' proprietary XRpro® technology directly measures the activity of ion channels and transporters, without the need for costly and artifact-causing chemical dyes or radiolabels, providing measurements that would otherwise be difficult or impossible using other technologies.

05/04/2015

We benefit from a solid IP estate, including 30 issued and pending patents, the majority of which is based on innovations developed by members of the XRpro team. http://bit.ly/1DZaTCE

05/01/2015

XRpro Sciences, Inc. provides a unique platform for drug discovery and development services featuring high throughput ion channel and transporter assays for the pharmaceutical industry. http://bit.ly/1DZ2dMF

04/30/2015

Our mission is to support the success of drug discovery programs through innovative and enabling cell-based assay services. http://bit.ly/1DZp7Ui

04/23/2015

XRpro Sciences, Inc. is pleased to announce that the Company will be presenting at the Taglich Brothers 12th Annual Investment Conference on May 5, 2015 in New York City. A webcast will accompany the presentation. More info here: http://bit.ly/1K9GGpT