02/20/2026
Intermittent Fasting and Hepatic Fat Metabolism
Time-restricted feeding (14–16 hour fasting window) has been shown to:
• Improve insulin sensitivity
• Reduce hepatic triglyceride content
• Lower ALT levels
• Enhance autophagy
During fasting, the liver shifts from glucose processing to fat oxidation. This reduces intrahepatic fat stores and activates cellular repair pathways.
Autophagy — the cellular cleanup process — plays a key role in preventing progression from fatty liver to fibrosis.
Fasting is a metabolic intervention, not a trend.