Onpharma Company

Onpharma Company Onpharma's Onset EZ Pen is the easy choice for buffering. The Onset System is simple to use and allows the clinician to inject and go right to work.

Onpharma's Onset is a revolutionary buffering system that uses Sodium Bicarbonate to raise the pH level of local anesthetic. Onset makes your local anesthetic reliable, predictable and more comfortable for the patient.

πŸ“£ Calling all Colorado dental professionals! Join us at the Rocky Mountain Dental Conference to experience the differenc...
01/05/2026

πŸ“£ Calling all Colorado dental professionals! Join us at the Rocky Mountain Dental Conference to experience the difference of Onset EZ!
➑ https://rmdconline.com/

THIS! ⬇️
12/26/2025

THIS! ⬇️

12/21/2025

Buffer ALL of your local anesthetic injections!

We’re heading to  in Denver, January 22–24, join us for 3 days of education, innovation and connection!
12/19/2025

We’re heading to in Denver, January 22–24, join us for 3 days of education, innovation and connection!

12/11/2025

Address

123 West Nye Lane, Suite 723
Carson City, NV
89706

Opening Hours

Monday 9am - 5pm
Tuesday 7am - 5pm
Wednesday 7am - 5pm
Thursday 7am - 5pm
Friday 7am - 2pm

Telephone

+18773366738

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Onset Buffering System

Chair side buffering using the Onset system is simple to incorporate, easy to use, and will make your local anesthetic better whether you are using Articaine, Lidocaine, Priolocaine or Mepivicaine.

Because local anesthetic is a key part of so many procedures in the dental office, a long-standing question among dental practitioners has been: How can we make our local anesthetic better? Chemistry lies at the heart of the answer. Local anesthetics begin as alkaline solutions, but manufacturers add hydrochloric acid to lower the pH to around 3.5 (or the same as lemon juice) in order to deliver a multi-year shelf life. However, a long-settled principal of parenteral injections is that an injection should be delivered at a pH as close as possible to the pH of the human body, approximately 7.4.

Onpharma gives dentists their first practical way to buffer the local anesthetic cartridge at chair side toward physiologic pH so practitioners no longer have to deliver an injection having the pH of lemon juice.