11/11/2025
Sounds like progress is being made
Golden retrievers are one of the world’s most beloved dog breeds, but researchers have just discovered a hidden genetic risk that can tragically cut their lives short. A study has revealed the first gene mutation in dogs linked to hypertrophic cardiomyopathy, or HCM, a heart condition that thickens the left ventricle and makes it harder for the heart to pump blood. While often silent, HCM can cause dangerous heart rhythms, blood clots, and sudden death.
This discovery came after scientists studied three young golden retrievers who all died suddenly from cardiac failure. By comparing their DNA to thousands of other dogs, wolves, and coyotes, the team pinpointed a mutation in the TNNI3 gene, the same gene tied to juvenile HCM and sudden death in humans. What makes this even more concerning is that the mutation is autosomal recessive, meaning dogs need to inherit two faulty copies, one from each parent, to develop the disease. Carriers may appear perfectly healthy yet unknowingly pass the gene on.
For golden retriever owners, this finding brings hope as much as concern. Genetic testing can now help identify carriers and prevent the spread of this mutation, keeping the breed healthier. Beyond dogs, the similarities to human HCM could also advance research into heart disease in people. This groundbreaking work was led by researchers at North Carolina State University.
Research Paper 📄
DOI: 10.1161/CIRCGEN.125.005096