09/24/2025
Emerging preclinical research suggests that cannabidiol (CBD) and cannabigerol (CBG) not only help manage fracture pain but also actively promote stronger bone healing. Unlike nonsteroidal anti-inflammatory drugs (NSAIDs), which may impair the early inflammatory phase necessary for bone repair, CBD and CBG provide analgesic benefits without disrupting this crucial stage (Khajuria et al., 2023).
In animal studies, these cannabinoids increased the number of periosteal bone progenitor cells, which later differentiate into osteoblasts—the cells responsible for new bone formation (Khajuria et al., 2023). This effect, combined with enhanced mineralization of the initial fibrocartilaginous callus, resulted in higher bone volume fraction and bone mineral density compared to untreated groups. Mechanical testing further revealed that the regenerated bone demonstrated improved strength and stiffness, suggesting a reduced risk of re-fracture (Khajuria et al., 2023).
At the cellular level, CBD and CBG have also been shown to enhance osteogenic differentiation in human mesenchymal stem cells, upregulating osteoblast-related genes and supporting mineral deposition (Bortoluzzi et al., 2023). These combined findings indicate that CBD and CBG may not only accelerate fracture healing but also produce bone that is stronger and more resilient than before the injury.
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References:
Bortoluzzi, D., Giordano, M., Tasso, R., & Quarto, R. (2023). Cannabidiol and cannabigerol enhance osteogenic differentiation in human mesenchymal stem cells: Potential role in bone regeneration. Biomedicines, 13(8), 1891. https://doi.org/10.3390/biomedicines13081891
Khajuria, D. K., Karuppagounder, V., Nowak, I., Sepulveda, D., Lewis, G., Norbury, C., Raup-Konsavage, W., Vrana, K., & Kamal, F. (2023). Cannabidiol and cannabigerol, nonpsychotropic cannabinoids, as analgesics that effectively manage bone fracture pain and promote healing in mice. Journal of Bone and Mineral Research, 38(11), 1480–1494. https://doi.org/10.1002/jbmr.4902
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