MUSC Department of Pathology and Laboratory Medicine

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MUSC Department of Pathology and Laboratory Medicine

Welcome to the MUSC Department of Pathology and Laboratory Medicine page!

02/14/2026

Happy Valentine’s Day from MUSC Pathology ❤️

02/05/2026

It is time for our February case of the month! This is a case of a 75 year old female with a history of chronic kidney disease, systemic lupus erythematosus, rheumatoid arthritis, and heart failure who was admitted to the hospital after an episode of acute chest pressure. The workup included a cardiac PYP nuclear imaging scan to rule out cardiac amyloidosis which showed radiotracer activity in the apex and inferior apical wall. A cardiac biopsy was performed and showed the above findings. What do you think, is it straightforward amyloidosis?
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Of course not! We're going to the zoo to find some zebras today! These images show myocytes with cytoplasmic vacuoles, patchy cardiomyocyte hypertrophy, and a Congo Red stain negative for amyloid deposition. On electron microscopy there are concentric lamellar structures (myeloid or zebra 🦓 bodies) and scattered curvilinear bodies. Zebra bodies are classically associated with Fabry disease but they can occur in other settings as well, including rheumatoid arthritis, drug-induced phospholipidosis, and other diseases. In this patient, the finding is most likely a result of hydroxychloroquine induced cardiotoxicity. 💔🦓

02/03/2026

We had a rare winter storm with SNOW here in Charleston last weekend! Perfect weather to cut frozen sections☃️🔬❄️! Shout out to the emergency teams and our team A resident who held down the fort at the hospital through the storm!
’sme ’mTeamA

01/30/2026

Happy end of January! Our residents enjoyed New Years, the annual holiday department party (at an aquarium! 🐠), and hanging around Charleston. Happy 2026 to everyone!

12/31/2025

2025! 🪩 It's been REEL fun, so here's a compilation of bloopers and outtakes from the year💃🕺Can't wait to keep laughing through residency in 2026!

12/22/2025

Here's a look back at some of the research, conference, and academic pursuits of our residents this past year! 🤓🔬

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12/16/2025

Happy holidays to all the residents who participated in the annual resident white elephant gift exchange (whether your gift was legit or a gag) and our annual resident holiday party! 🎁🎉🥳

12/01/2025

November! 🦃 This month flew by with conferences and sightseeing around the country, our annual department Thanksgiving potluck, happy hour on the water, new babies (human & canine!), renaissance fair fun, cytopathology shenanigans, and much more! We hope everyone enjoyed the long holiday weekend to close out November!

>turkey

11/30/2025

Hello it's time for our November case of the month! This month we have a 24 year old woman presenting with a cystic lesion of the left o***y on ultrasound undergoing a unilateral salpingo-oophorectomy. The histology findings are attached above, what do you think? Did blocks get switched cause it doesn’t look like o***y! 🫢😱😱😱😬😳
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This is a mature cystic teratoma! These tumors display growth of different mature tissues like skin, hair,
teeth, cartilage, etc. But, some cases show more uncommon findings like this one! Though skin with
adnexal structures are present we also see a focus of thyroid (Image 2 and 3) along with neuroglial tissue
(image 3 and 4). These findings are important as the patient may need thyroid function tests due to
potential ectopic production of thyroid hormone. In addition, screening for the presence of anti-NMDA
encephalitis is needed as some patients with brain tissue within teratomas will develop an autoimmune
condition affecting their own native brain tissue. Thanks for reading!

11/26/2025

ASCP! 🔬🧫 Congrats to our residents that presented posters and our faculty that hosted an educational session at ASCP this year! The self-driving car ride was ALMOST as cool as our presentations 🚙🤖

11/25/2025

Last week we started the holiday festivities early at our annual Pathology Department Thanksgiving potluck 🦃Shoutout to Dr. Spruill for the expert turkey carving! 🍗🍎🥔🍽️

11/21/2025

People have been aSKINg if our residents do research… here’s a couple of our sMART1 residents who knocked our SOX off and recently went to Baltimore for a conference! Congratulations on presenting posters at !

Address

171 Ashley Avenue
Charleston, SC
29425

Telephone

+18437925008

Website

https://medicine.musc.edu/departments/pathology

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