02/21/2026
Peripheral Artery Disease: The Silent Progression We Cannot Ignore
As we enter another year confronting peripheral artery disease (PAD) in the United States and across the world, we must pause and confront the magnitude of what stands before us.
Peripheral artery disease is not rare. It is not benign. And it is not slowing down.
The Numbers We Must Face
• In the United States, an estimated 8.5 to 12 million Americans are living with PAD.
• Globally, more than 230 million people are affected.
• PAD prevalence increases sharply with age — affecting over 20% of individuals older than 80.
• Patients with PAD have a 2–3× higher risk of cardiovascular death compared with those without the disease.
But what concerns me most is progression.
Among patients classified as Rutherford Category 3 (severe claudication):
• Approximately 5–10% will progress to critical limb-threatening ischemia (CLTI, Rutherford 4–6) within 1–2 years, particularly in the presence of diabetes, smoking, renal insufficiency, or poorly controlled risk factors.
• Once patients transition into Rutherford 4 (ischemic rest pain), the risk curve steepens dramatically.
• Within one year of developing CLTI, studies demonstrate:
• 15–25% risk of major amputation
• 20–25% mortality rate
• Up to 50% mortality at 5 years
These are not minor statistics. These are life-altering trajectories.
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The Challenge Before Us
We face more than plaque and calcification.
We face:
• Insurance restrictions that shape care pathways
• Conservative treatment barriers
• Delayed referrals
• Underdiagnosis in primary settings
• Inconsistent surveillance
• Fragmented responsibility
And yet the solution remains remarkably consistent:
1. Risk Factor Modification
• Smoking cessation
• Aggressive lipid control
• Antiplatelet therapy
• Glycemic optimization
• Blood pressure management
2. Supervised and Structured Walking
Walking is not trivial advice.
Walking promotes collateral vessel development, improves endothelial function, and enhances functional capacity. It is biologic therapy.
3. Early Recognition of Subtle Change
Patients must be educated to report:
• Shorter walking distances
• Night pain in the foot
• Dependent rubor
• New numbness
• Slow-healing wounds
Small changes precede catastrophic ones.
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A Call to Physicians
I say this clearly and without apology:
Physicians must remain directly involved in the care of patients with PAD.
Examine your patients.
Lay hands on your patients.
Palpate pulses.
Inspect the skin.
Look at the toes.
Ask the hard questions.
Delegation has its place — but responsibility cannot be delegated.
The roles are distinct.
The training is distinct.
The burden of decision-making is distinct.
At the end of the day, the physician carries the final accountability — not just to the patient, but to society.
Our responsibility is not reimbursement.
Our responsibility is limb salvage.
Our responsibility is life preservation.
Reimbursement is secondary.
Excellence is primary.
And when excellence is primary, reward follows naturally.
As I have said before:
Let the dollar chase you — do not chase the dollar.
If we educate the next generation early, intervene decisively when necessary, and remain hands-on stewards of this disease, we can alter the trajectory.
PAD is progressive — but neglect is optional.
Let us choose vigilance.
Let us choose responsibility.
Let us choose life and limb salvage.
— Dr. James N. Antezana
FSVS, RPVI