09/20/2023
I am passing along this post from a Perinatal Epidemiologist Dr. Marit bovbjerg. I found it a good read.
NEW BOOSTERS Epidemiologist opinion--get one.
I'm waiting a few more weeks for novavax. (aside: Current variants, there are two, present either with sore throat/stuffy nose/etc OR as massive GI issues. That poopy plane? Probably cvid. Keep an N95 on your face in public spaces. No one needs to breathe that in.) Background--Pfizer and Moderna had new mRNA boosters approved by FDA on Monday and by ACIP (a CDC panel) yesterday. Novavax (a protein-based vaccine, more like your normal kind of vaccine) was approved by ACIP on Tuesday with the other two, but we're still waiting on FDA. Should be within a month; they have submitted the data, and the data look very good. From my read of the data, all three will keep you out of the hospital, and all three are a decent match to variants currently circulating. BUT Novavax does a better job at preventing infection in the first place. Which means it's better protection against long cvid, which honestly is what I'm worried about at this point.
We are very good at treating acute infections now (partly this is because many folks have already died, so the ones who are left are healthier, but also healthcare workers have learned a lot in the last 4 years), but there's a 10-30% risk of medium- and long-term nasty complications with each infection. You want to risk it? Novavax is also more variant-resistant, and immunity doesn't wear off as quickly as it does with the mRNAs.
Finally, Novavax is being trialed as a treatment for long cvid, so if you have a prior infection, it may help with any viral persistence issues you're having. Novavax has fewer side effects, too, but that is not part of my calculus; I'd happily take the horrible 24 hours post-mRNA if they were otherwise better. But I don't think they are. Previously, novavax was only approved as a booster if you hadn't already had an mRNA booster. I'm really glad ACIP got over themselves and is now allowing it for everyone 12 and up.
--Marit bovbjerg MD