MPN Research Foundation

12/09/2025

As a lifelong entrepreneur, Jeremy approached his diagnosis like a business challenge. He created what he called an “MPN Life Plan,” complete with goals, measurable outcomes, and a mission statement. He tracked data, optimized his health, and committed to never giving up.

At MPN Research Foundation, we invest in bold, patient-driven science that transforms stories like Jeremy’s from uncertainty to empowerment.

💬 What’s one mindset shift that helped you through a challenge?

🔗 Support research that changes lives: https://goto.mpnresearchfoundation.org/4nBJZOE

12/05/2025

The American Society of Hematology (ASH) Annual Meeting is the world’s largest gathering of blood cancer experts. Every year, thousands of scientists and clinicians come together to share new discoveries, clinical trial updates, and advances that shape the future of care for people living with blood disorders.

For the MPN community, ASH is one of the most important moments of the year. Research presented at this meeting often reveals new ways of understanding myeloproliferative neoplasms, emerging treatment strategies, and insights that help doctors make more informed decisions for their patients.

MPN Research Foundation is proud to see members of our boards, advisory teams, and research award winners presenting their brilliant discoveries at 2025 ASH! Save travel and best of luck!

Want to learn more about the insights we found at ASH? Join our community today: https://goto.mpnresearchfoundation.org/3XzZs7i

Sign up to join our MPN Research Foundation community to receive our monthly e-newsletter, Under the Microscope, our print Newsletter, and other timely communications about what’s happening in the MPN community, including:

12/04/2025

We’re stronger together.

When people living with rare diseases like myeloproliferative neoplasms (MPNs) share their health data and experiences over time, it helps researchers see the bigger picture and expand understanding.

Enroll in the MPN PROGRESSion Registry™ and help give back to this determined community, working diligently toward change.

At this time of year when we focus on friends and family, being thankful, and giving — your time and data can make a real difference for those living with this rare disease now and in the future. One data point, one story, one breakthrough at a time.

👉 Learn more, sign up today and be part of the progress. https://goto.mpnresearchfoundation.org/3VSmaqq

12/03/2025

“What I love about what I do is that I can take the questions patients ask me in clinic and go back to the lab to start finding answers,” says Dr. Brandi Reeves, MD.

A 2024 MPN Challenge™ award recipient, Dr. Reeves is leading one of the first studies to understand why kidney disease affects so many people with MPNs and how to prevent it.

Her team’s early results suggest that a familiar therapy, interferon-alpha, may help protect the kidneys in addition to its other benefits. This research could one day allow doctors to detect and stop kidney disease before it causes harm. 💙

Your support fuels discoveries like this.
👉 Donate Today: https://goto.mpnresearchfoundation.org/4nBJZOE

12/02/2025

Maddie was just 12 when her world changed. What seemed like allergies spiraled into a diagnosis of rare, life-threatening condition, Budd-Chiari syndrome, caused by her blood cancer, a myeloproliferative neoplasm (MPN). Her childhood vanished overnight — replaced by hospital rooms and fear.

But hope emerged.

“MPN Research Foundation gave my family and me hope and community during many medical struggles that were confusing and isolating.” — Maddie

Today, Maddie’s disease is controlled, and she dreams of becoming an MPN researcher herself.

This Giving Tuesday, you can make that hope possible for patients like Maddie.

Your gift funds research, connects families, and brings us closer to a cure.

👉 Donate now: https://goto.mpnresearchfoundation.org/4nBJZOE

11/28/2025

Do you ever wonder where your donation goes?

At MPN Research Foundation, your donation powers the future of rare blood cancer treatment.

This year we were proud to fund an emerging opportunity using CRISPR gene editing technology to precisely target and eliminate MPN cells.

You can learn more directly from the lead researcher, Dr. Shannon Elf, MD during our special webinar:

Past. Present. Progress: Bold Ideas that Change Lives
Giving Tuesday, Dec. 2, 2025
5 – 6PM
Register: https://goto.mpnresearchfoundation.org/49ng5u2

This isn't science fiction. This is real research, happening right now, made possible by your support. Reaching our $2 million goal will ensure more discoveries like this can move forward.

Donate today: https://goto.mpnresearchfoundation.org/4nBJZOE

11/26/2025

Kyle became a caregiver overnight when her mom was diagnosed with an MPN.
Ten years later, they’re still celebrating milestones together.
Caregivers are the unsung heroes of every patient journey.

💭 Tag a caregiver who inspires you or share your story in the comments.

Donate today: https://goto.mpnresearchfoundation.org/4nBJZOE

11/25/2025

This Thanksgiving, we’re thankful for YOU — every patient who has joined the MPN PROGRESSion Registry™ and helped kickstart new discoveries.❣️

Since our launch last month, 318 inaugural participants have already enrolled, which fills us with excitement and gratitude. Your willingness to share your time and long-term health data will help researchers unlock new understanding of essential thrombocythemia (ET), polycythemia vera (PV), myelofibrosis (MF), and other rare myeloproliferative neoplasms (MPNs).

If you haven’t joined yet, consider adding your MPN story to this growing collective study. Enrolling is simple, secure, and designed to only take a limited amount of your time.

Your data can help us drive progress over progression.

💛 Learn more and enroll today: https://goto.mpnresearchfoundation.org/3VSmaqq

11/21/2025

“This isn’t science fiction. This is real research — happening right now.”

On Giving Tuesday, Dec 2, you’ll hear how CRISPR is being used to target MPN cells with precision, and how your support is making it possible.

🎙️ Join us for a powerful webinar featuring Dr. Shannon Elf, our CEO Kapila Viges, and real MPN patients.

💭 What gives you hope for the future of cancer research?

Drop your thoughts in the comments 👇

🔗 Register now: Webinar Registration - https://goto.mpnresearchfoundation.org/49ng5u2

11/20/2025

📢 Today is the day!

Join us at 5 PM CT for our next MPN Pathways: Empowered Voices in Research Webinar — Clinical Trial Protocol 101

Discover how clinical trial protocols are designed and how YOU can influence them.

🎤 Expert advocate Jane Perlmutter, Ph.D., MBA will guide you through Clinical Trial Protocol 101.
📅 TODAY Nov. 20 | 5–6 PM CT
✅ Register now to attend live or get the recording: https://goto.mpnresearchfoundation.org/48KyxMQ

Your voice matters. Your feedback can shape research. Don’t miss this chance to make an impact!

11/19/2025

“Excitement,” says 2024 MPN Challenge™ award recipient Dr. Robert Kralovics. “Every new batch of data is one little step forward.”

Your support keeps that excitement alive.

This fall, his team at the Medical University of Vienna shared important new insights into how the immune system responds to mutated calreticulin (mutCALR) — a key driver of some MPNs.

After studying more than 130 patients, they found that naturally occurring antibodies called anti-mutCALR IgG did not slow cancer cell growth as expected. “Anti-mutCALR IgG level did not impact the mutant CALR clone size or CALR allelic burden,” the report noted.

For Dr. Kralovics, even unexpected results are valuable. “It just shows that MPN is not a simple thing. Nothing is easy — but every new batch of data shows one little step forward.”

Now his team is testing next-generation antibodies that help immune cells better recognize and destroy MPN cells — research that could lead to more effective, immune-based therapies.

Every step counts. You can help move the next discovery forward.

👉 Make an Online Donation: https://goto.mpnresearchfoundation.org/4nBJZOE

11/17/2025

Behind every breakthrough are real people.

From patients and caregivers to researchers, clinicians, and the biopharmaceutical industry, we are relentless in the fight for better outcomes for those living with essential thrombocythemia (ET), polycythemia vera (PV), and myelofibrosis (MF).

We were proud to represent the MPN community on a global stage by:
👉sparking critical discussion about disease progression and unmet needs of patients & caregivers at 17th International MPN Congress.
👉introducing the MPN PROGRESSion Registry at CR&T Patient Symposium on MPNs.
👉bringing scientific and medical expertise to MPN Horizons.

And in December, we’re presenting at the American Society of Hematology (ASH)’s Annual Meeting to continue to advocate for health disparities faced by essential thrombocythemia (ET), polycythemia vera (PV), and myelofibrosis (MF) patients around the world.

The year is winding down, but we are not. With your support, we are determined to finish the year strong by raising $2 million for MPN research.

Will you help us close the gap and donate today? https://goto.mpnresearchfoundation.org/4nBJZOE