JAMA Otolaryngology—Head & Neck Surgery

04/09/2026

Among patients aged 16 to 65 years with recurrent or chronic tonsillitis, recovery time did not differ significantly between intracapsular and extracapsular tonsillectomy. Intracapsular approaches were associated with lower pain intensity and faster return of daily function. https://ja.ma/3QeVlgp

04/09/2026

Internet-based cognitive behavior therapy ( ) for patients with tinnitus demonstrated sustained reductions in tinnitus distress over a 6-year follow-up period in a nonrandomized clinical trial.

https://ja.ma/40BlDvp

04/06/2026

A 41-year-old patient was referred to the oral and maxillofacial surgery department with slight mobility of the upper right canine with occasional swelling. What is your diagnosis?

A 41-year-old patient was referred to the oral and maxillofacial surgery department with slight mobility of the upper right canine with occasional swelling. What is your diagnosis?

04/05/2026

In a cohort study of patients with HPV-associated squamous cell carcinoma ( ) of the palatine tonsil, completion transoral robotic surgery ( ) following diagnostic tonsillectomy did not increase rates of positive surgical margins, perineural invasion, extranodal extension, or affect three-year survival compared to patients without prior tonsillectomy.

Residual tumor was found in over half of revision TORS cases, but overall outcomes were similar, supporting the oncologic safety of diagnostic tonsillectomy prior lateral oropharyngectomy.

https://ja.ma/4m7VA8O

04/04/2026

Among patients with advanced head and neck squamous cell carcinoma ( ) treated with immunotherapy, pretreatment BMI loss and low prognostic nutritional index (PNI) were independently associated with shorter progression-free survival, whereas baseline BMI category was not.

These findings indicate that dynamic measures of nutritional status and immune function, such as BMI trajectory and PNI, may be more meaningful prognostic markers than static BMI. Nutritional decline was common, supporting the relevance of nutritional assessment before immunotherapy initiation.

https://ja.ma/4c6U1U2

04/03/2026

Clinicopathologic factors associated with circulating tumor human papillomavirus DNA ( ) levels were assessed in patients undergoing surgery for HPV-mediated oropharyngeal squamous cell carcinoma ( ).

Higher preoperative ctHPVDNA levels correlated with pathologic nodal stage and kidney function, while lower levels were found in patients with perineural invasion and extranodal extension.

Detectable postoperative ctHPVDNA was observed in 20% and was associated with multiple positive lymph nodes, high preoperative ctHPVDNA, perineural invasion, and extranodal extension, highlighting the potential for ctHPVDNA to inform biomarker-driven clinical trials and postoperative risk assessment.

https://ja.ma/4vdfymY

03/30/2026

A population-based cohort study including over 570 000 adults aged 50 years or older in Denmark assessed the association between , hearing aid use, and incident .

Hearing loss was linked to an increased risk of developing dementia, with the greatest risk observed among individuals who did not use hearing aids.

Hearing aid users showed a lower risk, approaching that of people without hearing loss.

These results suggest hearing aids may help prevent or delay dementia onset and progression, although the observed risk increase was smaller than that reported in previous studies, highlighting the need for further longitudinal research.

🎥 Watch the video and read the full article: https://ja.ma/4uTnsSl

03/28/2026

New research highlights Amivantamab as a promising treatment for recurrent or metastatic adenoid cystic carcinoma—a rare and difficult-to-treat cancer.

Trisha Wise-Draper, MD, PhD, professor of medicine and section head of medical oncology at the University of Cincinnati, discusses study findings, clinical benefits, and future directions with Paul Bryson, MD, director of the Cleveland Clinic Voice Center.

🎧 Listen now:

Interview with Trisha M. Wise-Draper, MD, PhD author of Amivantamab for Recurrent or Metastatic Adenoid Cystic Carcinoma: A Phase 2 Nonrandomized Clinical Trial. Hosted by Paul C. Bryson, MD MBA.

03/27/2026

A 20-year-old woman had, since age 8 years, a lesion on the left side of her face that had slowly progressed over 12 years, causing facial asymmetry. Examination revealed an ill-defined soft tissue mask, and imaging showed bone involvement.

📝 What is your diagnosis?

https://ja.ma/4bOZlv4

03/26/2026

In a cohort study of older adults from the ARIC study, poor olfactory identification was associated with worse lower-extremity muscle strength, balance, gait speed, and grip strength, as well as faster declines in these physical function measures over 7 years.

was linked to lower Short Physical Performance Battery scores and greater annual decreases in functional outcomes, suggesting relevance for identifying individuals at risk of physical decline in late life.

https://ja.ma/40S1tNR

03/25/2026

A 36-year-old man with a 4-year history of Crohn disease who was receiving maintenance therapy with infliximab presented with 6 months of progressive left mandibular pain and swelling.

What is your diagnosis? https://ja.ma/47RWhNG