02/27/2026
If treatment is supposed to help… why do some patients feel worse at first?
With complex infections, this can be a normal part of the process. When we start antimicrobials, the immune system may react by releasing inflammatory signals (cytokines), which can temporarily increase symptoms — think fever, headaches, chills, or a flare of what you were already feeling.
The good news: we have tools to help you through it, and in many cases it’s a sign your immune system is finally recognizing and responding to what’s been driving symptoms!
Always let your provider know what you’re experiencing so we can support you safely and adjust your plan if needed.