02/06/2026
A secondary analysis of the GHSG HD21 randomized trial evaluated health-related quality of life among patients with advanced-stage classic receiving BrECADD vs escalated BEACOPP regimens.
BrECADD was associated with reduced chemotherapy-related symptoms, including lower rates of peripheral neuropathy, cognitive fatigue, and dyspnea, and improved physical and role functioning after 4 cycles in PET2-negative patients.
Enhanced cognitive, emotional, and social functioning persisted through the second year of follow-up, supporting BrECADD’s favorable tolerability and recovery profile.
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