JAMA

04/08/2026

💬 Viewpoint by Jacob Kannarkat, MD, Priyanka Abraham, MHA, and Jaime King, JD, PhD:

Despite widespread adoption of tools in clinical practice, workflow integration remains a key barrier for clinicians, with current federal interoperability policies emphasizing access rather than usability.

The Health Data, Technology, and Interoperability (HTI-5) proposed rule extends protections for AI-enabled tools, but structural constraints—termed “workflow blocking”—limit real-time integration and function during patient care. Addressing usability gaps will require policy approaches that consider both data access and meaningful clinical workflow support.

https://ja.ma/4mfgjHQ

04/08/2026

From 2015 to 2023, the number of US patients prescribed long-term therapy (≥90 days) declined by 24%, with 4.2 million individuals receiving long-term opioid prescriptions in 2023.

During this period, the population shifted toward older adults and higher coverage, and mean daily morphine milligram equivalents decreased. Coprescribing of benzodiazepines declined while gabapentinoid and stimulant coprescribing increased, raising safety considerations for older adults receiving long-term opioid therapy.

https://ja.ma/4t6Zpy4

04/08/2026

💬 Editorial: Simulation modeling indicates that using apolipoprotein B ( ) as a target for statin intensification yields the highest quality-adjusted life-years and remains cost-effective compared with non–high-density lipoprotein cholesterol (non–HDL-C) and low-density lipoprotein cholesterol (LDL-C) guided strategies.

Sensitivity analyses confirmed that not only identifies more patients eligible for intensification but also more clinically meaningful residual cardiovascular risk. These findings support the revised 2026 ACC/AHA dyslipidemia guideline approach and expand the evidence for -guided lipid management.

https://ja.ma/4dA9UF9

04/08/2026

Among statin-eligible, ASCVD-free US adults, a computer simulation found that using apolipoprotein B ( ) as a marker to guide intensification of lipid-lowering therapy was most cost-effective compared to low-density lipoprotein cholesterol ( -C) and non–high-density lipoprotein cholesterol ( -C) goals.

The apoB strategy provided the greatest gains in quality-adjusted life-years and reduction in atherosclerotic cardiovascular disease events, with only marginal increases in health care costs, supporting the use of apoB-guided treatment in primary prevention.

https://ja.ma/3QcGPFX

04/08/2026

📊 Research Summary: Stereotactic radiation provided better patient-reported quality of life and functional independence for patients with 5 to 20 brain metastases than hippocampal-avoidance whole brain radiation.

This study aimed to assess whether stereotactic radiation focusing on individual brain metastases reduces symptom burden and interference with daily functioning compared with hippocampal-avoidance whole brain radiation in patients with 5 to 20 brain metastases.

04/08/2026

RCT: Among patients with 5 to 20 brain metastases, stereotactic radiation targeting individual tumors improved symptom severity and interference with daily functioning compared to hippocampal-avoidance whole brain radiation. These results support the use of stereotactic radiation for this population, highlighting a paradigm shift toward precision techniques that prioritize patient quality of life. Salvage whole brain radiation after stereotactic treatment was infrequent, particularly with regular MRI–based surveillance.

This randomized clinical trial assesses whether stereotactic radiation, compared with hippocampal-avoidance whole brain radiation, improves symptom severity and interference with daily functioning in US patients with 5 to 20 brain metastases and no prior brain-directed radiation.

04/08/2026

What are , and how are they shaping clinical practice?

In under a minute, JAMA+ AI Editor in Chief Roy Perlis, MD, MSc, breaks down the basics, then explains how can directly impact researchers and clinicians.

JAMA+ AI is the JAMA Network home for the latest advances in the application of artificial intelligence in medicine – from clinical practice to research and education.

To learn more, visit JAMA+ AI: https://ja.ma/4meppVo

04/08/2026

💬 Viewpoint: The 2025-2030 Dietary Guidelines for Americans weakened evidence-based recommendations for plant-predominant diets, potentially impacting efforts to reduce disease, , and .

This Viewpoint discusses the recent release of the 2025-2030 Dietary Guidelines for Americans (DGAs) in the context of prior recommendations from the Dietary Guidelines Advisory Committee’s 2025 scientific report and prior DGAs.

04/07/2026

📌 Editor’s Choice from this week's issue of JAMA:

➡️ How BNP and Ultrasound Improve Volume Overload Detection,
➡️ Tenecteplase 4.5 to 24 Hours After Ischemic Stroke,
➡️ Stereotactic Radiation for Brain Metastases, and more.

https://ja.ma/3NRaMe6

04/07/2026

Among women worldwide, is the eighth most common malignancy and cause of cancer death. In 2025, it is estimated that 20 890 US women will be diagnosed with ovarian cancer and 12 730 will die of it.

📄 This JAMA Patient Page describes ovarian cancer and its risk factors, symptoms, diagnosis, and treatment.

https://ja.ma/4sjsUey

04/07/2026

💬 Perspective: As increasingly guides diagnosis, documentation, and patient management, physicians’ roles are changing, prompting questions about sustaining empathy, accountability, and trust in algorithmic care.

https://ja.ma/3ObXUPD

04/07/2026

📊 Research Summary: In patients with non–large-vessel occlusion stroke and salvageable tissue, tenecteplase extended to 24 hours improved outcomes compared with standard care but increased bleeding risk.

https://ja.ma/48ew4ZW