05/03/2021
Adequate Vitamin D is apparently mandatory for naïve T cells to be activated against SARS-CoV-2 and other pathogens
"So why are some people unable to mount a good protective T-cell response? The key to this question might be a 10-year-old Danish study led by Carsten Geisler, head of the Department of International Health, Immunology and Microbiology at the University of Copenhagen [8]. Geisler noted that "When a T cell is exposed to a foreign pathogen, it extends a signalling device or 'antenna' known as a vitamin D receptor, with which it searches for vitamin D,", and if there is an inadequate vitamin D level, "they won't even begin to mobilize." In other words, adequate vitamin D is critically important for the activation of T-cells from their inactive naïve state. The question of whether T-cells might also need a continuing supply of vitamin D to prevent the T-cell exhaustion and apoptosis observed in some serious COVID-19 cases [9] deserves further research."
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T cells
Article Related content Article metrics Rapid responses Response Rapid Response: T-cells really are the superstars in fighting COVID-19 - but why are some of us so poor at making them? Dear Editor, Thank you to Dr Doshi for raising the profile of T-cells. Incidentally, German researchers found that....