Arc Ancient Aromatherapy

Arc Ancient Aromatherapy Premium essential oils, skillfull blends, distributorships...Since 1994 Astrologer since 1980 Home of the signature roll on application.

Aromatherapy company since 1990, with full line of Therapeutic grade A aromatherapy products. Provider of essential oils and products to the health care industry and the lay person. Distributorships available.

08/08/2025

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06/24/2025

Alchemy of the Soul is the true story of one woman’s life experiences including several Near-Death Experiences, Out of Body experiences, Angelic Visits and Guidance omens, dreams, visions, Paranormal experiences, psychic experiences that have guided her path in finding the spiritual connections i....

05/17/2025

Uranus will not conjoin the sun in TA**us again, until 2103. EARTH SHAKING

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Natural Dietary Supplementation of Curcumin Protects Mice Brains against Ethanol-Induced Oxidative Stress-Mediated Neuro...
02/20/2025

Natural Dietary Supplementation of Curcumin Protects Mice Brains against Ethanol-Induced Oxidative Stress-Mediated Neurodegeneration and Memory Impairment via Nrf2/TLR4/RAGE Signaling
The aim of the current study was to explore the underlying neuroprotective mechanisms of curcumin (50 mg/kg, for six weeks) against ethanol (5 mg/kg i.p., for six weeks) induced oxidative stress and inflammation-mediated cognitive dysfunction in mice. According to our findings, ethanol triggered reactive oxygen species (ROS), apoptosis, neuroinflammation, and memory impairment, which were significantly inhibited with the administration of curcumin, as assessed by ROS, lipid peroxidation (LPO), and Nrf2/HO-1 (nuclear factor erythroid 2-related factor 2/Heme-oxygenase-1) expression in the experimental mice brains. Moreover, curcumin regulated the expression of the glial cell markers in ethanol-treated mice brains, as analyzed by the relative expression TLR4 (Toll like Receptor 4), RAGE (Receptor for Advanced Glycations End products), GFAP (Glial fibrillary acidic protein), and Iba-1 (Ionized calcium binding adaptor molecule 1), through Western blot and confocal microscopic analysis. Moreover, our results showed that curcumin downregulated the expression of p-JNK (Phospo c-Jun N-Terminal Kinase), p-NF-kB (nuclear factor kappa-light-chain-enhancer of activated B cells), and its downstream targets, as assessed by Western blot and confocal microscopic analysis. Finally, the expression of synaptic proteins and the behavioral results also supported the hypothesis that curcumin may inhibit memory dysfunction and behavioral alterations associated with ethanol intoxication. Altogether, to the best of our knowledge, we believe that curcumin may serve as a potential, promising, and cheaply available neuroprotective compound against ethanol-associated neurodegenerative diseases.
Follow this link for full article:
https://pmc.ncbi.nlm.nih.gov/articles/PMC6566393/

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