05/29/2026
Ozempic, originally developed for Type 2 diabetes, is now widely used for weight loss, but new research shows serious effects on muscle and organ health.
A study in Cell Metabolism found Ozempic reduces lean mass by around 10% in mice, with the liver shrinking nearly 50%, raising concerns about long-term organ function.
Researchers observed a mismatch between muscle size and strength, with some muscles staying the same size but losing power, suggesting potential frailty risk and reduced physical performance in animal models — effects requiring confirmation in human clinical trials.
Older adults may face a higher risk, as age‑related weakness combined with potential drug‑related declines in strength may undermine independence, mobility, and overall longevity.
Long-term use of Ozempic and similar GLP-1 drugs is also associated with adverse side effects like dental issues, eye damage, mental health risks, and possible weight regain following discontinuation.