Kantor Neurology

11/28/2024

In Memoriam: Professor Giancarlo Comi - 12/15/1947 - 11/26/2024

It is with great sadness that we mourn the passing of a global giant in the field of MS. Professor Giancarlo Comi was born not far from Milan, Italy where he attended university, medical school and served in many many leadership, organizational and academic roles. He was a passionate visionary force in the field of MS who enjoyed life to the fullest. He was lecturing at conferences until his last days; the world of MS will miss him greatly.

On a personal note, he was always very supportive of the videos we filmed at conferences and was a leader who was hopeful about a future with even better MS control.

Dr. Daniel Kantor speaks with Professor Giancario Comi, Director and Chairmen of Neurology at Vita-Salute San Raffaele University about the changing strategi...

11/22/2024

Read WebMD article Top 5 Ways to Tell Memory Lapses From Dementia written by Rachel Ellis and reviewed by Dr Daniel Kantor

There are key ways to tell if your memory issues are typical ones everyone has sometimes or signs of dementia.

10/19/2024

: Session on Emerging Tools Enabling Clinical Development chaired by Mark Frasier The Michael J. Fox Foundation for Parkinson's Research - highlighted publicly-available biomarker pipeline: https://zenodo.org/communities/mjff/records?q=&l=list&p=1&s=10&sort=newest

10/18/2024

: Martin Gill on small molecule activation of TRPML1 to enhance lysosomal function and protein clearance for the therapeutic treatment of . https://www.labiotech.eu/partner/virtual-biotech-company-leveraged-data-accelerate-drug-development/

10/18/2024

: on brain-penetrant small molecule GT-02287 is well tolerated in healthy volunteers (nausea) — shows GCase target engagement. Read https://www.neurologylive.com/view/understanding-therapeutic-potential-gt-02287-gba-parkinson-disease

10/18/2024

: Angela Cacace Arvinas on Discovery of ARV-102 Oral PROTAC LRRK2 Degrader. For more on PROTAC: Magazine https://www.nature.com/articles/s41587-021-01173-2

10/18/2024

: Allyx Therapeutics on moving beyond to using mGluR5 Silent Allosteric Modulator, ALX-001 (Bristol Myers Squibb BMS-984923) — Alberto Espay, can we understand this if we don’t go all-in on “toxic” misfolded protein hypothesis that is taken for granted? [silent = no effect on glutamate]. Needed to explain away why there is actually more alpha synuclein in substantia nigra treated mice … why doesn’t that raise more questions?

10/18/2024

: Progress in Therapeutic Pipeline chaired by Bruce Morimoto Alto Neuroscience moving beyond “targets” to pathways and mechanisms also. Need: models that translate, target engagement bionarkers for dose-effect and sensitive biomarkers for disease biology. “Together” we will make tremendous success/steps.

10/17/2024

: At Annual The Michael J. Fox Foundation for Parkinson's Research Therapeutics Conference opens with Sohini Chowdhury admitting that over the last 24 years, we have not lived up to the promise to … yet!

10/11/2024

Thank you Nova Southeastern University for having Daniel Kantor lecture on in Case-Based learning.

10/09/2024

Read Rapid Response to : https://jme.bmj.com/content/50/4/246.responses -to-the-rescue — don’t scapegoat the unvaccinated for the pandemic.

Individuals unvaccinated against COVID-19 (C19) experienced prejudice and blame for the pandemic. Because people vastly overestimate C19 risks, we examined whether these negative judgements could be partially understood as a form of scapegoating (ie, blaming a group unfairly for an undesirable outco...

10/04/2024

Does your pre-op routine involved dance? How about a flash mob dance party? https://youtu.be/uPdheFjRm4E?si=zjbAuhRzKBSBTTRV Dr Deborah Cohan’s does. UCSF School of Medicine UCSF

The hub of the world-wide virtual flash mob dancing to Get Me Bodied before Deb's double mastectomy. Please support Deb's Healing Through Movement Fund! http...

10/01/2024

: Thank you to MDS International Secretariat for a wonderful, interesting and engaging conference in Philadelphia, PA. If you are interested in more educational videos — check out https://youtu.be/k75EByvMkgQ?si=FzIix5cyhQJeDPuR WeHealth. For other topics: https://youtube.com/?si=PZ8WnqXZRw9JH76D If there are other conferences or topics that you want to see coverage of, please comment below.

Videos by Daniel Kantor, MD, FAAN - President Emeritus, Florida Society of Neuroloy (FSN).

10/01/2024

: and : Same: YES -
Daniel Weintraub University of Pennsylvania: Very similar, a lot of overlap. has 90% conversion to # PD, LBD, DLB (& MSA). Differences are quantitative not qualitative. NO -
Glenda Halliday University of Sydney Parkinson's NSW https://www.parkinsonsnsw.org.au/glenda-halliday-named-nsw-scientist-of-the-year/ DLB much more like & does not need nigrostriatal cell loss & has more . Divergent neuroprotective mechanisms. PDD spared from cortical atrophy. Not biologically the same.

Internationally acclaimed neuroscientist Professor Glenda Halliday FAA FAHMS from the University of Sydney is the 2022 NSW Scientist of the Year.

10/01/2024

: Controversies in Movement Didorders session chaired by Francisco Cardoso Christopher Goetz Rush University System for Health Rush University: Will Replace Clinicians in the Diagnosis of Movement Disorders: YES - Ray Dorsey University of Rochester Just like we have genetic nondiscrimination (GINA), we may need a data nondiscrimination act (DINA) https://www.eeoc.gov/statutes/genetic-information-nondiscrimination-act-2008 NO - Abhimanyu MahajanUniversity of Cincinnati AI makes up data; research isn’t transparent; oversight is needed; once you take out doctors, there aren’t “patients” anymore but “consumers.” Consumers need protection (too). Extreme - man commits su***de bc chatbot told him to sacrifice life to stop climate change: New York Post https://nypost.com/2023/03/30/married-father-commits-su***de-after-encouragement-by-ai-chatbot-widow/ When scans were introduced, people said that it would replace physicians — but a tool, not replacement.

“When he spoke to me about it, it was to tell me that he no longer saw any human solution to global warming,” the widow said.

09/30/2024

: Margherita Fabbri
on Designing Trials for Neuroprotective Treatments — bur which outcomes make sense? Nandakumar Narayanan University of Iowa on Repurposing Existing Drugs — 119 million known chemical structures. Terazosin (but not Tamsulosin) binds to PGK1 — so boosts brain ATP. Used Merative database. Muramatsu Shinichi Jichi Medical University on Gene Therapy: Bench to Bedside: Protection of dopaminergic neurons in ; suppression of subthakamic nucleus activation (AAV-GAD); Protection of dopaminergic neurons (GDNF) — did not work; AAV-hAADC. AAV-TH & AAV-GCH & AAV-AADC.

09/30/2024

: Prof. Irina Alafuzoff University on Understanding the Brain Aging: Lessons from the Brain Bank — minority had only a-synuclein. Pitfalls - staging; sampling; selection bias; methodology. Brainet Europe: https://www.brainbank.nl/about-us/brain-net-europe/ “I feel sorry for the clinicians” = bc there is so much overlap. Thomas Beach Banner HealthHealth on Multiple Pathologies in Parkinsonism: A Rule or Rarity? 100% of people w or wo have tangles in their 60s. When pathologists see 4+ cortical microinfarcts, there are 400+. TDP43 (LATE, hippocampal sclerosis, FTLD-TMP, MBD). People with more than healthy controls. Non-AD taupathy in PD — ARTAG (then ARGgrs) most common. ?Glioblastomas more in ? Yaroslau Compta Hospital Clínic de Barcelona on Clinical Implications ? Secondary glymphatic dysfunction? Consider multi-targeted therapy — ala cancer, antibiotics and autoimmune disease.

The Netherlands Brain Bank is a member of Brain Net Europe (BNE), a network of 19 European Brain Banks. One of BNE's goals is coordinating brain banking procedures.

09/30/2024

: Clinical Breakthroughs - Chairs: Maria Stamelou & Matt Stern University of PennsylvaniaPennsylvania Jingqi Fan on Liquid Chromatograph Mass Spectrometer and Mendelian Randomization Based on Serum Metabolomics Biomarker Discovery of Parkinson’s Disease. Joaquim Ferreira on Long-term follow-up of Opicapone use as add-on to Levodopa in Parkinson’s Patients Without Motor Fluctuations: Findings From the EPSILON Study. Pablo Mir on Combined Physiotherapy and Cognitive Behavioral Therapy for Functional Movement Disorders.