Cold Spring Harbor Laboratory

Cold Spring Harbor Laboratory At the center of life science research and education for over 130 years. program and other educational offerings.
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We are organized into six divisions:

Research: Generates knowledge that will yield better diagnostics and treatments for cancer, neurological diseases, and other major diseases, and that will lead to improved and more diverse food resources and more efficient biofuels. School of Biological Sciences: Trains the next generation of scientists through an innovative Ph.D. Meetings and Courses: Brings together more than 11,000 scientists each year from around the world to present and evaluate new data and ideas in biological research. Banbury Center: Provides a crossroads where scientists discuss important topics in molecular biology, human genetics, and science policy, among others. DNA Learning Centers: Educates the public about genetics through the nation’s first science centers dedicated to this purpose. CSHL Press: Publishes invaluable materials for the worldwide scientific community and the public.

Right on time for this spring weather.... research published today, provides plant breeders a new tool to confront futur...
03/12/2026

Right on time for this spring weather.... research published today, provides plant breeders a new tool to confront future challenges, from droughts to food scarcity.

In a new study in Science, CSHL's Zachary Lippman lab and colleagues at The Hebrew University of Jerusalem and Sainsbury Laboratory Cambridge identify more than 2.3 million regulatory DNA sequences conserved across 284 plant species—some more than 400 million years old.

Learn more on the "Secrets of evolution found in ancient plant DNA": https://www.cshl.edu/secrets-of-evolution-found-in-ancient-plant-dna/

03/12/2026

For Women’s History Month, we remembering legendary geneticist Barbara McClintock through personal memories from Phil Renna - McClintock's friend and colleague at CSHL.

From walking campus in oversized galoshes to cracking black walnuts for her legendary pound cake, Phil offers a rare glimpse of the personality behind the scientist whose discoveries changed genetics forever.

Barbara McClintock Stats:

🔬 Elected to the Academy of Sciences — only the third woman to be elected

👩‍🔬 Became the first female president of the - Genetics Society of America

🏅Received the Prize in Physiology or Medicine in 1983—the first woman to win it unshared + the first American woman to win any unshared Nobel Prize in science

🧬 The Nobel Foundation honored her for discovering Mobile Genetic Elements, or “jumping genes”—a breakthrough that transformed how scientists understand DNA and continues to influence medicine, biotechnology, and agriculture today.

03/11/2026

From frozen ❄️ to flowing 🌊

As the warmer days grow nearer, Cold Spring Harbor Laboratory's Communications team documented the thawing of the recently frozen inner harbor.

We are thrilled to congratulate CSHL Assistant Professor Corina Amor Vegas who was named a recipient of the 2026 MIND Pr...
03/10/2026

We are thrilled to congratulate CSHL Assistant Professor Corina Amor Vegas who was named a recipient of the 2026 MIND Prize!

This coveted prize is awarded annually to five to seven investigators who dare to challenge conventional thinking around neurodegenerative diseases, including Alzheimer’s disease and dementia, which affect millions worldwide.

Corina is developing a new CAR T cell–based strategy for Alzheimer’s disease by targeting damaged, inflammatory aging cells outside the brain. The MIND prize will support her lab’s vision of creating a safer and long-lasting approach to prevent or treat cognitive decline.

Read more on Corina's Alzheimer's research. https://www.cshl.edu/corina-amor-vegas-awarded-750k-mind-prize/

This International Women’s Day, we’re honored to announce and celebrate Kate Doerge as the 2026 Women’s Partnership for ...
03/09/2026

This International Women’s Day, we’re honored to announce and celebrate Kate Doerge as the 2026 Women’s Partnership for Science Luncheon honoree!

Through pennysflight, Kate raises awareness and funding for neurofibromatosis type 1 (NF1), honoring the legacy of her daughter Penny.

CSHL scientist Linda Van Aelst will present research advancing the fight against NF1.
Save the Date: CSHL’s Women’s Partnership for Science will be held on Sunday, September 27, 2026. Learn more & support women in science — https://www.cshl.edu/giving/womens-partnership-science/.

Get your spoon ready for ! 🥄When you think of your favorite cereal, you might think it's been made with wheat or corn.B...
03/07/2026

Get your spoon ready for ! 🥄

When you think of your favorite cereal, you might think it's been made with wheat or corn.

But a new crop has entered the cereal game: sorghum!

Sorghum is a versatile grain that is among the top five cereal crops in the world. It is naturally high in fiber, antioxidants, proteins, iron, as well as drought-resistant and gluten-free.

CSHL Adjunct Professor Doreen Ware has been studying sorghum for years now, hoping to amplify crop yields and boost the plants’ resilience to adverse environmental conditions.

Already in one study, Ware's team identified genetic variations that occurred in sorghum’s MSD2 gene, increasing the grain number by 100 percent.

As more research is being done on sorghum (and as the general public begins to identify it as a superfood), it will likely appear in more brands throughout the country.

Keep your eyes out for more sorghum 👀

As we celebrate Women’s History Month, this episode highlights two women whose determination and discovery are helping d...
03/06/2026

As we celebrate Women’s History Month, this episode highlights two women whose determination and discovery are helping define the next generation of scientific leadership. Every scientific breakthrough has a beginning. Behind each discovery are researchers at the earliest stages of their careers, driven by curiosity, resilience, and a willingness to embrace uncertainty.

In our latest episode of At the Lab, we sit down with a graduate student and a postdoctoral fellow to talk about what it really feels like to build a life in science. From failed experiments to adapting to life in a new country, this conversation offers an honest look at the early chapters of a research career: https://www.cshl.edu/podcasts/life-as-an-early-career-scientist/


03/06/2026

In honor of Endometriosis Awareness Month, CSHL Assistant Professor Semir Beyaz and his research team in the Seckin Endometriosis Research Center at Cold Spring Harbor Laboratory is taking The Endometriosis Foundation of America to stand with the 1 in 10 women affected by this disease.

If one bite is torture, imagine years of chronic pain, inflammation, fatigue, and delayed diagnosis.

The biology behind endometriosis remains largely unexplored. At CSHL, we’re working in partnership with Seckin Endometriosis Center to change that through the Seckin Endometriosis Research Center—the first center dedicated to endometriosis within a basic science institution in the U.S.

Using cutting-edge approaches, under the leadership of Dr. Semir Beyaz, researchers are working to uncover biomarkers for earlier diagnosis and new therapeutic targets, advancing our understanding of endometriosis as a complex, nerve-centric disease.

We are deeply grateful for those women's health advocates who continue to use their voices to bring visibility to a disease that has been silenced for far too long.

Today, the Beyaz team challenges:

Elsie Hewitt & Pete Davidson

Bite the lemon. Share the message. Donate to the cause (https://give.endofound.org/campaign/one-for-the-cure-endo-awareness-month-2026/c771838). Nominate three more.

Let’s make endometriosis impossible to ignore.

03/05/2026

Evelyn Witkin was a powerhouse in the field of genetics and CSHL was lucky enough to have her research here for over 10 years. Witkin's Ph.D. research was based on DNA mutagenesis, which later led to research on DNA repair and the mechanism of the SOS response to UV radiation in bacteria.

In 2002, she received the National Medal of Science from President Bush for her "insightful and pioneering investigations on the genetics of DNA mutagenesis and DNA repair that have increased our understanding of processes as varied as evolution and the development of cancer.”

Evelyn was the 2016 guest speaker at CSHL's annual Women's in Partnership for Science Luncheon, a summer staple among female philanthropists who support biomedical research. Her story moved guests to tears. Hear Evelyn's inspiring story from that presentation titled "Serendipity in Spades: My Crooked Path to Cold Spring Harbor”, found here: https://www.youtube.com/watch?v=TiMi6xxkrKw

Talk about a legacy at the Lab...

For March, we're turning our attention to the groundbreaking female scientists of Cold Spring Harbor Laboratory. Women's...
03/03/2026

For March, we're turning our attention to the groundbreaking female scientists of Cold Spring Harbor Laboratory. Women's History Month allows us to spotlight scientists past and present who are leading trailblazing research, educating future pioneers, and using science to make lives better tomorrow.

Congrats to CSHL's Lucas Cheadle for receiving The Eagles Autism Foundation grant, which contributed $10.8 million to fu...
03/02/2026

Congrats to CSHL's Lucas Cheadle for receiving The Eagles Autism Foundation grant, which contributed $10.8 million to fund 54 projects specializing in cutting edge autism research and care!

This grant will support Cheadle's pilot project: Dissecting the roles of maternal:fetal antigenicity and placental endocrine function in an inflammatory mouse model of autism.

💚 Thank you Philadelphia Eagles Nation. Go Birds!


https://www.philadelphiaeagles.com/news/eagles-autism-foundation-contributes-10-8-million-to-fund-54-research-community-projects

For , there’s hopeful news from the U.S. Food and Drug Administration 💙Professor Adrian Krainer explains the FDA's new ...
02/28/2026

For , there’s hopeful news from the U.S. Food and Drug Administration 💙

Professor Adrian Krainer explains the FDA's new “Plausible Mechanism Pathway” guidance — which was released this week.

Its aim is to provide a more flexible way to move personalized treatments for ultra-rare genetic diseases into clinical trials and toward approval. It's based on the "why it should work" in lieu of large-scale, randomized clinical trials.

Instead of requiring large, traditional trials (which can be nearly impossible for ultra-rare conditions), this pathway focuses on something just as important:

✔️ Is the therapy hitting its intended biological target?
✔️ Are the first patients showing real, measurable improvement?

For families facing ultra-rare diseases, time matters. This approach could help promising, custom-built therapies move closer to patients in need.

It’s science meeting urgency — and turning deep biological understanding into real-world hope

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Cold Spring Harbor, NY
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Our Story

We are organized into six divisions: Research: Generates knowledge that will yield better diagnostics and treatments for cancer, neurological diseases and other major diseases, and that will lead to improved and more diverse food resources and more efficient biofuels.

DNA Learning Centers: Educates the public about genetics through the nation’s first science centers dedicated to this purpose.

Watson School of Biological Sciences: Trains the next generation of scientists through an innovative Ph.D. program and other educational offerings.

Meetings and Courses: Brings together more than 11,000 scientists each year from around the world to present and evaluate new data and ideas in biological research.