The Laboratory of Dr. Jean-Philippe Pellois

The Laboratory of Dr. Jean-Philippe Pellois Our goal is to determine how proteins function in space and time in the context of complex cellular networks.

We focus on chemistry-driven approaches to manipulate protein structure beyond what is feasible with standard genetics.

10/31/2017

Erazo-Oliveras conducts research in the college’s Program in Integrative Nutrition and Complex Diseases laboratory. By Research Communications and Public

10/01/2010

PubMed is a service of the U.S. National Library of Medicine that includes over 19 million citations from MEDLINE and other life science journals for biomedical articles back to the 1950s. PubMed includes links to full text articles and other related resources.

10/01/2010

PubMed is a service of the U.S. National Library of Medicine that includes over 19 million citations from MEDLINE and other life science journals for biomedical articles back to the 1950s. PubMed includes links to full text articles and other related resources.

10/01/2010

PubMed is a service of the U.S. National Library of Medicine that includes over 19 million citations from MEDLINE and other life science journals for biomedical articles back to the 1950s. PubMed includes links to full text articles and other related resources.

10/01/2010

PubMed is a service of the U.S. National Library of Medicine that includes over 19 million citations from MEDLINE and other life science journals for biomedical articles back to the 1950s. PubMed includes links to full text articles and other related resources.

10/01/2010

Here is a nice movie of a red fluorescent protein entering a cell by escaping from endosomes (the red dots in the first image). The protein was initially internalized into the cell by macropinocytosis, a process in which a cell drinks up its environment. At this point the protein is trapped inside endosomes. These organelles are within the cell but the protein does not have access to other parts of the cell. By learning about the biology of the cell and using various chemical tricks, one can however engineer the protein so that it can escape from endosomes (that’s not so easy to achieve though!). At this point, the protein can diffuse into the cell, find its target and exert a therapeutic effect.

Address

300 Olsen Boulevard (Bio/Bio) Room 430
College Station, TX
77843

Telephone

(979) 845-0101

Website

http://biochemistry.tamu.edu/?ch=faculty&sec=name&pp=pellois

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Videos

Escaping from Endosomes
Escaping from Endosomes

Here is a nice movie of a red fluorescent protein entering a cell by escaping from endosomes (the red dots in the first image). The protein was initially internalized into the cell by macropinocytosis, a process in which a cell drinks up its environment. At this point the protein is trapped inside endosomes. These organelles are within the cell but the protein does not have access to other parts of the cell. By learning about the biology of the cell and using various chemical tricks, one can however engineer the protein so that it can escape from endosomes (that’s not so easy to achieve though!). At this point, the protein can diffuse into the cell, find its target and exert a therapeutic effect.

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