02/21/2026
💉 Cortisone vs. Hyaluronic Acid vs. PRP for Knee Osteoarthritis — Which One Is Right for You?
If you’re dealing with knee pain from osteoarthritis, your doctor may have mentioned one of these three injection options. But how fast do they work, how long do they last, and what will it actually cost you?
Cortisone is the fastest acting of the three — many patients feel relief within just a few days. It’s typically covered by insurance and low cost, making it the most accessible option. However, the relief is often short-term and frequent use can have drawbacks over time.
Hyaluronic Acid takes a few weeks to kick in but can keep you comfortable for up to six months. Coverage varies by insurance plan, so it’s worth checking before your appointment.
PRP is the most regenerative option, using your own blood to stimulate healing from the inside out. It has the most promising long-term potential — but it’s usually not covered by insurance and can run several hundred dollars or more out of pocket.
Not sure which is best for you? That’s exactly what the comparison table at the end of this reel is for. Watch through to see how all three stack up side by side.
👇 Comment below — have you tried any of these injections? We’d love to hear about your experience.