10/10/2025
Name brand: Benadryl
Generic: Diphenhydramine
Mechanism of action: H1 receptor antagonist (this receptor is responsible for vasodilation and bronchoconstriction which helps in allergic reactions. It also blocks acetylcholine which controls memory and attention)
Used for allergies, hives, sleep
Adverse reactions: drowsiness, dizziness, headache, low blood pressure, increased heart rate, anaphylaxis, seizures, long term use is linked to dementia
Use in pregnancy: No known risk of fetal harm
Use in breastfeeding: Possible risk of infant CNS depression (sleepiness, slowed breathing). May decrease milk production
Alternatives: For allergies, D Hist and D Hist Jr, ginger, spirulina, honey, essential oils lemon, lavender and peppermint, acupuncture, air purifier
For sleep: Holy basil, lemon balm, ashwagandha, magnesium