Dalton Cardiovascular Research Center

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Columbia, MO
Dalton Cardiovascular Research Center

Dalton Cardiovascular Research Center is a highly collaborative dept. of the Univ. of Missouri focusing on causes for many human diseases.

Dalton Cardiovascular Research Center is making great strides toward understanding the causes of many diseases, including hypertension, cancer, cystic fibrosis and heart disease. With this understanding comes the development of new and improved therapies - the ultimate goal of our researchers. Dalton investigators have earned excellent local, national and international reputations based on their publications, successful acquisition of national grants and presentations at scientific meetings. Dalton partners with many units across the campus. Investigators hold primary academic appointments in one of several colleges such as the School of Medicine, the College of Veterinary Medicine, the College of Engineering, and the College of Arts and Science. The facility houses molecular biologists, cell biologists, biochemists, biological engineers, electrophysiologists and integrative physiologists. Collaboration between scientists within the center and across campus is one of the greatest strengths of Dalton's efforts. Dalton scientists enjoy access to graduate programs, teaching and training opportunities. In turn, academic units gain access to research facilities, resources and laboratory space that would otherwise be unavailable, adding to MU's recruitment and retention efforts. Areas of study such as microcirculation, neural control of circulation, membrane transport and exercise biology focus scientists' expertise on common problems. It is rare to find such a concentration of diverse disciplines within the same building, and at Dalton this critical mass of collaborating scientists leads to rapid advances and discoveries of biological mechanisms related to human health and disease.

01/06/2025

08/07/2024

Tzyh-Chang Hwang, PhD Laboratory publishes in Nature

“Allosteric inhibition of CFTR gating by CFTRinh-172 binding in the pore”

Xiaolong Gao, Han-I Yeh, Zhengrong Yang, Chen Fan, Fan Jiang,
Rebecca J. Howard, Erik Lindahl, John C. Kappes, &
Tzyh-Chang Hwang

Loss-of-function mutations of the CFTR gene cause the
life-shortening genetic disease cystic fibrosis (CF).

Using cryogenic electron microscopy, Gao et al. uncovered how CFTRInh-172 inhibits CFTR function by binding in its pore and allosterically inhibiting its gating. Their findings could pave the way for structure-based drug design for the treatment of secretory diarrhea and polycystic kidney disease.

08/01/2024

David Kline, a professor in Mizzou’s College of Veterinary Medicine and researcher at the Dalton Cardiovascular Research Center study of high blood pressure and its link to sleep apnea:
https://showme.missouri.edu/2024/how-does-the-brain-respond-to-sleep-apnea/?utm_campaign=553184_Show%20Me%20Mizzou%20-%20Tuesday%2C%20July%2030%2C%202024%20%28ALL%29&utm_medium=email&utm_source=The%20Curators%20of%20the%20University%20of%20Missouri&dm_i=7IQU,BUU8,3GWGR2,1S7YB,1

04/17/2024

Congratulations!

Yoko Wang, PhD
receives MU Postdoctoral Research Grant from
the MU Office of Postdoctoral Education

Dr Wang joined Dalton in September of 2023
and is a Biomedical Sciences post doctoral fellow
in the Laboratory of Carie Boychuk, PhD

Address

1500 Research Park Drive
Columbia, MO
65211

Telephone

(573) 882-7588

Website

http://dalton.missouri.edu/

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