Nizar Saad Lab at Nationwide Children's Hospital

08/21/2024

It is with immense joy and satisfaction that I announce the receipt of my first multi-year NIH funding to advance the translational research portfolio of the Nizar Saad Lab at Nationwide Children's Hospital!
This NIH funding is part of the Senator Paul D. Wellstone Muscular Dystrophy Specialized Research Centers (MDSRC) P50 grant, recently awarded to our Center for Gene Therapy at Nationwide Children's Hospital.
It’s incredibly rewarding to see all the late hours and hard work over the years come to fruition! This is what we literally call a dream come true!

بفرح ورضا عظيمين، أُعلن عن حصولي على أول تمويل متعدد السنوات من المعهد الوطني للصحة (NIH).
هذا التمويل هو جزء من منحة مركز السيناتور بول دي. ويلستون المتخصص في أبحاث
ضمورالعضلات التي تم منحها مؤخرًا لمركزنا للعلاج الجيني في مستشفى نيشن وايد للأطفال
من المُجزِ أن أرى العمل الجاد في الساعات المتأخرة على مدار السنوات تُثمر
أخيرًا! هذا ما نُسميه حرفيًا بحلم وتحقق

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06/26/2024

I am very proud of Bilal Bayazit, a postdoc in the Saad Lab, who recently received a one-year research grant from Friends of FSH Research to continue his search for exosome-associated circulating molecular biomarkers for FSHD!

Bilal started working on this project less than a year ago, and has already generated interesting data on this topic using funds from the Chris Carrino Foundation for FSHD and samples from an initial patient cohort. These findings will be soon submitted for publication. So, stay tuned!

Congratulations, Bilal on this great achievement, and thank you, Friends of FSH Research and Chris Carrino Foundation for FSHD for your continuous support!

07/06/2023

I am very happy to announce the completion of the E4B program in innovation and entrepreneurship for biomedicine organized by the Washington University in St Louis and directed by Emre Toker and Jesse Davis, MD. A special thanks to my mentors Patrick J. Wethington and Arvan Chan, and to my teammates Mai-Lan Ho, MD, Matt S., PhD and Jacob Oscherwitz for this intensive but great, rich and comprehensive experience! I have enjoyed every part of this program and the great interaction with my teammates and feedback from my mentors and program directors, which I am sure will be highly valuable for my career as a scientist in a translational research setting.

06/23/2023

Yesterday was a historical day for the Duchenne Muscular dystrophy (DMD) community, for Nationwide Children's Hospital and for our Center For Gene Therapy! The FDA approved the first gene therapy for DMD! Duchenne is the most prevalent muscular dystrophy followed by FSHD, which is another muscular dystrophy that my lab is investigating. Gene Therapy is considered one of the most advanced therapeutics that is expected to change the course of Medicine related to many diseases, especially rare genetic disorders. Our Center and Nationwide Children’s Hospital is at the forefront of gene therapy, and I am so grateful to work in this innovative environment with very bright scientists! بالأمس كان نهار تاريخي للأشخاص المصابين بالحثل العضلي الدوشيني، لمستشفى الأطفال في كولومبس اوهايو ولمركز البحوث في العلاج الجيني. إدارة الأغذية والدواء الأميركية (FDA) وافقت على أول علاج بالجينات لمرض الحثل العضلي الدوشيني. هذا المرض هو من أكثر الأمراض العضلية شيوعا وياتي بعده مرض الحَثَلُ العَضَلِيُّ الوَجْهِيُّ الكَتِفِيُّ العَضُدِيّ (FSHD) الذي هو احد الامراض التي اطور ابحاث حولها في مختبري في مركز البحوث في العلاج الجيني. يعتبر العلاج الجيني من أكثر العلاجات تطورا والذي متوقع ان يغير في مسار الطب وعلاج الكثير من الأمراض وخاصتا الأمراض الجينية النادرة. مركز البحوث في العلاج الجيني ومستشفى الأطفال في كولومبس هم من الرواد في العالم في العلاج الجيني وانا ممتن كثيرا لكوني اعمل في هذه البيئة الإبداعية ومع زملاء باحثين علماء لامعين.

06/20/2023

It was pleasure to be on Tim's podcast and the FSHD Radio to celebrate ! We talked about my journey in FSHD research and the FSHD Lab Day event that we are organizing on July 8 at Nationwide Children's Hospital, which will bring together FSHD families and scientists for the purpose of advancing the discovery of non-invasive blood biomarkers for FSHD.

https://fb.watch/lhTOAk3BGk/?mibextid=RUbZ1f

05/14/2023

I am happy to share the launch of my Nationwide Children's Hospital's research lab webpage.

The Saad Lab conducts cutting-edge research to understand the causes of genetic disorders, including neuromuscular diseases, and develops innovative techniques to diagnose, treat and cure these conditions.

04/29/2023

I have created a new Nationwide Children's Hospital's Facebook Fundraising page through which you can also donate for the Saad Lab http://give.nationwidechildrens.org/goto/SaaLab. Please check this page and share with your friends and family!

All donations are tax-deductible and will be acknowledged by Nationwide Children’s Foundation.

On behalf of the patients and families of Nationwide Children’s Hospital, thank you for your support!

This page is dedicated to raise funds to support the research conducted in the laboratory of Dr. Nizar Saad at the Center for Gene Therapy at Nationwide Children’s Hospital.

03/21/2023

For those who haven't seen this yet, I am happy to share the availability of a donation page to support the research conducted in my Lab. This is an opportunity to fund and accelerate the development of Gene Therapies for rare genetic diseases.

For donation please go to this page: "Give.NationwideChildrens.org/Saad_Lab".

To get more updates about our work, please follow the Nizar Saad Lab at Nationwide Children's Hospital page or send me an email. You can also follow updates by accessing our NCH page https://www.nationwidechildrens.org/find-a-doctor/profiles/nizar-y-saad-2.

Please share this announcement with your network to help spread the word about this opportunity. .

Nizar Y. Saad PhD

03/17/2023

New opportunity to donate to advance biomedical research and accelerate finding cures for genetic diseases.
I am happy to present the Saad lab located in the Abigail Wexner Research Institute at Nationwide Children's Hospital. My team is conducting cutting-edge research to understand the causes of genetic disorders, including neuromuscular diseases, with a focus on developing innovative techniques to treat, cure, and diagnose these conditions. Specifically, my team is dedicated to developing and bringing to the clinic new gene therapy approaches and to identify new blood biomarkers for diagnosis, prediction of disease progression, and evaluation of therapy effectiveness. Our research is focused on diseases such as Facioscapulohumeral Muscular Dystrophy (FSHD), Duchenne Muscular Dystrophy (DMD), Emery-Dreifuss Muscular Dystrophy (EDMD), Progeria and Dilated Cardiomyopathies (DCM) with LMNA mutations. However, our developed technologies could be applied to other diseases, and as such, we hope that our discoveries will be able to help in the future a wide range of patients with genetic conditions. Unfortunately, conducting such research is costly and governmental funding can only go so far. For this reason, we are seeking donations that will not only enable the acquisition of essential supplies, reagents, and equipment necessary for the successful ex*****on of our research but will also speed up the introduction of these groundbreaking gene therapies to clinics for the treatment of these debilitating diseases. Donations can be made through the donation page: Give.NationwideChildrens.org/Saad_Lab.

Please share this announcement with your network to help spread the word about this opportunity. .

Thank you for your donation, your support is very valuable!

Send a message to learn more

03/17/2023

I am happy to present the Saad lab's page. On this page, I will be sharing updates and new announcements regarding the research we do in the Saad Lab.