10/27/2025
Because there are many more people with one Z gene in the population, there may be as many individuals with liver disease associated with one Z gene as there are with two Z gene variants.
For more information, please visit bfrg.alphanet.org or the Subscriber Portal to access the Big Fat Reference Guide (BFRG).
To learn more about the potential risks associated with different Alpha-1 gene variants, check out AlphaNet's Alpha-1 Alleles website: https://www.alpha1alleles.com