05/05/2026
Clonidine ( 2-[(2,6-dichlorophenyl) amino]-2-imidazoline hydrochloride) is a drug that exerts its effects via its alpha-2 adrenergic agonism. It is commonly used to treat hypertension, attention deficit hyperactivity disorder, management of tics, cancer-related pain, and as an adjunct for neonatal opioid withdrawal syndrome.
Recently, clonidine has also found use as an adjunct in peripheral nerve blocks. A 2009 review of randomized placebo-controlled trials...