01/11/2026
In a phase II human clinical trial published in Clinical Cancer Research (2008) by Dhillon et al., researchers investigated high-dose oral curcumin (8 grams per day) in 21 patients with advanced, treatment-resistant pancreatic cancer. These were patients who had already failed standard therapies. Tumor response was monitored using imaging every few months while patients continued curcumin until disease progression.
The results showed biological activity in two patients. One patient experienced stable disease for more than 18 months, which is rare in advanced pancreatic cancer.
Another patient showed a brief but dramatic ~73% reduction in measurable tumor size before progression resumed. Blood analysis in this responder showed large changes in inflammatory and immune markers, confirming curcumin was biologically active in humans. Importantly, no dose-limiting toxicity or serious side effects were reported, even at this very high dose, which is why curcumin continues to be studied as a potential supportive or adjunct therapy, not a standalone cancer treatment.
PMID: 34572272