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09/02/2025

Researchers at the Harry Perkins Institute found that Melittin, the main peptide in bee venom, completely destroyed aggressive breast cancer cell membranes within 60 minutes in laboratory models—while largely sparing healthy cells.

Within 20 minutes, Melittin also suppressed key cancer-growth signals like EGFR and HER2. In mice, combining Melittin with chemotherapy (docetaxel) enhanced tumor reduction.

Though these findings are promising for targeted cancer strategies, they remain at the preclinical stage. More research is urgently needed to determine safe, effective delivery and to assess efficacy in human trials.

Source: Duffy C. et al. (2020). Honeybee venom and melittin suppress growth factor receptor activation in HER2-enriched and triple-negative breast cancer. npj Precision Oncology, 4, 24.

08/22/2025
08/15/2025

In a breakthrough that could reshape cancer treatment, scientists have discovered that honeybee venom can destroy 100% of aggressive breast cancer cells in less than 60 minutes. The key lies in a powerful compound called melittin, found in honeybee venom but not in bumblebee venom.

Researchers tested the venom on various breast cancer cell types in lab dishes and found that melittin acts like a precision-guided weapon. It punches holes in cancer cell membranes, causing the cells to die quickly. What’s even more promising is that melittin leaves healthy cells largely untouched, suggesting it could be used for treatments with fewer side effects than chemotherapy or radiation.

Melittin proved especially effective against triple-negative breast cancer and HER2-enriched breast cancer, two of the most difficult types to treat. This discovery opens new doors to developing safer, more targeted cancer therapies using natural compounds.

Scientists are now working to harness melittin’s cancer-fighting power in a controlled way, possibly through nanoparticles or synthetic versions that could be used in future medications. While more research is needed, this natural molecule from bees offers a powerful new weapon in the fight against cancer.

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