Texas Orthobiologics

09/29/2025

Stepping into Texas Orthobiologics felt like a warm embrace, thanks to the amazing staff and knowledgeable, kind doctor who guided me through my knee pain journey. If you're searching for expert orthopedic services in Dallas or the surrounding areas, this is the place to be. They offer exceptional care in regenerative medicine, helping alleviate back pain and more with advanced treatments like platelet-rich plasma therapy. Their approach to pain management is personalized and thorough, ensuring each patient receives care that is just right for them. For anyone dealing with joint discomfort, especially shoulder pain, check out Texas Orthobiologics and experience their dedication to improving your quality of life. Visit soon to explore your options and find the relief you've been hoping for.

09/23/2025

*The Las Vegas Regenerative Medicine and MSK Ultrasound Course* www.orthosono.com
*January 8-10, 2026 Virgin Hotel, Las Vegas*
We are back for our 18th year!
Hotel rooms in our block are $169 with NO resort fee and this hotel is part of the Hilton Curio Collection.....earn or use your Hilton points!
Thursday is a full day of practical regenerative medicine education. We review best practices based on the best data. We cover laser and shockwave and sustained acoustic medicine. We have live demos all afternoon!
Friday is upper extremity day. Lectures before lunch and 4 hours of upper extremity hands on after lunch with1 live model for every 2 trainees and 1 faculty for every 4 trainees.
Saturday is lower extremity and spine day with the same format!
Our course is partnered with the Interventional Orthobiologics Foundation and is the intro level training needed to take more advanced IOF orthobiologics curriculum.
www.orthosono.com

09/04/2025

Are you filtering your or plasma to increase IRAP? If not, Why not?
Larger plasma proteins like IRAP, A*M, and fibrinogen are typically not concentrated in the office centrifuges commonly used to make PRP and bone marrow concentrate. One of the major advantages of centrifuging blood and bone marrow is that the plasma can then be filtered to increase the concentration of these large plasma proteins which have many potentially beneficial effects for our orthopedic patients.
The Regenokin/Orthokine IRAP based drug is made in a procedure that takes 6-24 hours and is based on manipulating blood to create a higher concentration of IRAP (20x-50x) than baseline IRAP. It is a procedure that a clinician must license and pay for the privilege to use the technology. Needless to say it is not cheap and there is no MSC or HSC or platelet component.
Want to level up your orthobiologic practice without paying for an IRAP only procedure? We can take advantage of normal human biology. How? By using bone marrow concentrate as our source instead of blood. Bone marrow concentrate already has 15x-20x the concentration of IRAP in blood. So without the 6-24 hour processing time we can have a IRAP enhanced biologic in like 20-30 min. from aspiration to creation!!! Want to supercharge the result? By using a filter on the BMC plasma and reducing the plasma volume from 20cc to 4cc we can even increase the IRAP concentration another 5x....making the IRAP in filtered BMC 4x-5x even more concentrated than the stand alone blood based IRAP procedures. The added bonus? We get MSCs and HSCs AND we even get some platelet enhancement AND we even get more A*M! (more on that in another post)

08/12/2025

Be part of shaping IOF MAX 2026!

Next June might feel far off, but planning is already underway— and we want your input!

What topics do you want to explore? Who should take the stage? Which experts do you want to see face off in a clinical crossfire?

💬 Drop your ideas in the comments.

And if you haven’t already, mark your calendar to join us June 17–20 in Denver!

07/29/2025

Last chance to join us TONIGHT for a webinar on peptides covering clinical applications, the current regulatory landscape, and more! Free to attend, but you must register to receive the Zoom link: http://bit.ly/45RPOCo

⏰ 5 p.m. PT / 6 p.m. MT / 7 p.m. CT / 8 p.m. ET

Bring your questions, moderator Don Buford, MD will host a live Q&A with presenters Andrew S. Ittleman, Esq. and Steven AR Murphy, MD.

07/08/2025

*Patient testimonial* 20 months s/p one high dose knee (15 billion platelets) PRP injection done in the office under ultrasound guidance.

07/04/2025

Looking for regenerative medicine training for spine? Interventional Orthobiologics Foundation has a course September 27!

Ready to level up your spinal injection technique? Registration is open for our next Intermediate Spine Orthobiologics Injection Course.

This focused, one-day course was created for MD/DOs already using ultrasound in practice and ready to advance their orthobiologic injection skills for the thoracic and lumbar spine.

Learn more and save your spot: https://bit.ly/4lerbVi

07/03/2025

The truth about current use in the USA:
The most talked-about peptides in this field include BPC-157, TB-500 (Thymosin Beta-4 fragment), GHK-Cu, and IGF-1 LR3. These peptides have shown promise in lab or animal studies for things like tendon repair, muscle regeneration, or joint inflammation. It’s important to understand that none of these peptides are FDA approved for any medical use in humans in the U.S. They are not approved drugs, and using them in patients falls outside FDA regulations.
Clinicians may be told that obtaining these peptides through compounding pharmacies IS regulatory compliant. Compounding pharmacies are regulated by both state pharmacy boards and the FDA, but they are only allowed to make medications from a list of approved ingredients. Because peptides like BPC-157 and TB-500 are not on the FDA’s list of approved bulk drug substances, it is not currently legal for pharmacies to compound them for human use, even with a prescription. Therefore using these unapproved peptides on patients in the U.S. is considered non-compliant with FDA regulations and could lead to serious legal consequences for providers.
As for human research, clinical data is very limited. A 2023 review in Biomedicines (“The Emerging Role of BPC-157 in Musculoskeletal and Tendon Healing”) summarized some early human case reports and preclinical models but confirmed that rigorous human trials are still lacking. Similarly, GHK-Cu has shown tissue repair benefits in cosmetic and wound care studies, but not in controlled orthopedic trials. No significant randomized clinical trials have proven the safety or effectiveness of these peptides in orthopedic patients to date. Nonetheless peptides represent a potential treatment option for orthopedic patients IF the clinical science one day matched expectations!

06/24/2025

Patient TestimonialOur patient presents today 3 years after stem cell injections for multiple arthritic joints in his hands. Nothing else had worked for him...

06/19/2025

EVERYTHING you ever wanted to know about Platelet Rich Plasma ( ) injections
By Don Buford MD, Board Certified Orthopedic Surgeon and Founder of America's #1 Rated Regenerative Medicine and Orthopedic Surgery Clinic at Texas Orthobiologics.
___
# PRP Injections for Joint Pain: What They Are & How They Work

Stiff knees making your morning walk a struggle? Shoulder aches keeping you on the sidelines instead of in the game? Living with chronic joint pain can turn daily routines into obstacles and chip away at the activities you love most. For many, the idea of surgery or a lifetime of medication is daunting—and that’s where regenerative therapies like platelet-rich plasma (PRP) injections are changing the conversation around joint pain relief.

PRP injections tap into the body’s natural repair system, using your own blood to deliver a concentrated dose of healing factors directly to damaged tissues. This minimally invasive approach has captured the attention of patients and specialists alike, but it also raises important questions: What exactly is PRP? How is it prepared and administered? Which types of joint pain respond best? What does the medical evidence show—and what are the real-world benefits, risks, and costs?

This article is designed to answer those questions, offering a clear, step-by-step guide to PRP therapy for joint pain. Whether you’re researching alternatives to surgery, exploring options for a stubborn injury, or seeking a second opinion on your treatment plan, you’ll find the essential facts, latest research, and practical advice you need to make an informed decision about PRP. Let’s explore how this innovative treatment works and what you can expect if you’re considering PRP injections for joint pain.

# # What Is Platelet-Rich Plasma (PRP)?

Imagine using a natural, patient-derived solution to jump-start your body’s own repair process. [Platelet-Rich Plasma, or PRP](https://www.texasorthobiologics.com/platelet-rich-plasma-prp-injection-orthopedic-regenerative-medicine-experts-dallas-tx/) does exactly that. At its simplest, PRP is an autologous blood product—meaning it comes from your own body—concentrated with platelets and the proteins those cells release to support healing.

> **Definition (jargon-free)**
> Platelet-Rich Plasma (PRP) is a small sample of your blood that’s processed to increase the number of platelets—cells that release growth factors—so when it’s injected into an [injured joint](https://www.texasorthobiologics.com/blog/joint-pain/?bc=1400) or tissue, it may speed up repair and reduce inflammation.

Clinicians harvest a tube of your blood, spin it in a centrifuge to separate components, then collect the layer richest in platelets. Those platelets contain a mix of proteins—called growth factors—that signal surrounding cells to kick into repair mode. By delivering a high concentration of these factors directly where you hurt, PRP aims to support tissue regeneration rather than just mask symptoms.

# # # Key Components and Growth Factors

PRP’s healing potential comes from the cocktail of growth factors stored in platelet granules. Major players include:

- **PDGF (Platelet-Derived Growth Factor):** Encourages cell proliferation and attracts stem cells to the injury site.
- **TGF-β (Transforming Growth Factor-Beta):** Regulates inflammation and stimulates collagen production for matrix formation.
- **VEGF (Vascular Endothelial Growth Factor):** Promotes new blood vessel growth (angiogenesis), improving nutrient delivery.
- **EGF (Epidermal Growth Factor):** Accelerates cell division and supports tissue regeneration.

These factors work in concert to modulate inflammation, recruit reparative cells, and lay down new extracellular matrix. (Source: “The regenerative mechanisms of platelet-rich plasma: A review” [PubMed](https://pubmed.ncbi.nlm.nih.gov/34004552/).)

# # # How PRP Differs from Other Blood Products

Not all blood-derived therapies are created equal. PRP stands apart by its high platelet concentration:

| Product | Platelet Count (per μL) | Relative Concentration |
|---------------------------|-------------------------|------------------------|
| Whole Blood | 150,000–350,000 | 1× (baseline) |
| Platelet-Rich Plasma (PRP)| 1,000,000–2,000,000 | 2–8× |
| Platelet-Poor Plasma | 10,000–50,000 |