11/19/2025
Chemotherapy has revolutionized cancer treatment, significantly improving survival rates for many patients worldwide. However, its life-saving benefits often come at a cost, with nerve damage to the lower limbs emerging as one of the most debilitating side effects. Known as Chemotherapy-Induced Peripheral Neuropathy (CIPN), this condition affects nearly half of patients undergoing certain chemotherapy regimens, particularly those involving platinum-based agents such as Oxaliplatin. Despite the severity of the potential complications of neuropathy, a study from the University of South Australia reveals a distressing gap in supportive care: fewer than 20% of patients at risk utilize podiatry services that could dramatically alleviate their symptoms, improve their function and prevent complications. The results from the US population would be no doubt similar.
CIPN manifests as a constellation of sensory and motor impairments, including numbness, burning sensations, tingling, and muscle weakness that predominantly affect the feet. These symptoms often develop insidiously during or after chemotherapy, dramatically reducing patient quality of life. Podiatrists possess specialized skills in managing lower limb disorders and are uniquely positioned to address the multifaceted challenges posed by CIPN. Our expertise encompasses assessment, prevention, and treatment strategies aimed at preserving neuromuscular function, preventing falls, and minimizing foot trauma. Early podiatric intervention can contribute to fall prevention—a critical factor given that CIPN-related balance impairments significantly heighten fall risk. Moreover, effective podiatric care can reduce the incidence of ulcerations and infections, which, if left untreated, may escalate to amputations.
In our practice we have taken the additional step of addressing the nerve damage itself utilizing an innovative treatment, electric signal therapy with the Neurogenx Nerve Pro 2000 device. This sophisticated electrical therapy uses biosimilar electrical waveforms delivered through the skin to directly stimulate the damaged nerves promoting an increase in cellular metabolism and neurotransmitter release.
This can lead to improvement in nerve function and an increase in skin nerve fiber density. We have seen great clinical improvement in patients treated with this method over the last 7 years with over 85% of patients experiencing a positive effect.
If you or a loved one have been exposed to chemotherapy, we would be happy to help with any foot or leg issues including neuropathy.