10/13/2025
Wait, what? Nitroglycerin enhances brain perfusion during CPR?
A new swine study says yes, with a medication already in your med box.
Researchers evaluated nebulized nitroglycerin (NTG) during CPR and found a significant boost in carotid blood flow without negatively affecting aortic pressure.
๐ง Why it matters: Carotid blood flow is a key surrogate for cerebral perfusion. Improving flow to the brain during cardiac arrest could lead to better neurologic outcomes after ROSC.
๐ก Key Findings:
โ๏ธ Nebulized NTG increased mean carotid blood flow by 31%
โ๏ธ No significant drop in coronary perfusion pressure
โ๏ธ Safe and potentially easy to implement in prehospital and hospital settings
๐ NTG is commonly carried in EMS units, and the nebulized form may offer a new role in supporting cerebral perfusion during resuscitation โ without complicating CPR efforts.
๐งช Important: This study was conducted on a controlled porcine model, so it's not ready for prime time just yet. Human trials are obviously needed, but this is an exciting area of research that we'll be keeping our eyes on.
Read the paper here:https://www.handtevy.com/wp-content/uploads/2025/08/Nebulized-Nitroglycerin-Improves-Carotid-Blood-Flow-During-Cardiopulmonary-Resuscitation-in-a-Swine-Model-of-Cardiac-Arrest.pdf
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