02/11/2024
He and a growing community of scientists recognize the role of inflammation and lipids. "The major finding of my lab is that cholesterol actually drives the synthesis of amyloid via inflammation. In other words, amyloid is downstream of cholesterol. Cholesterol drives the inflammation, and the inflammation drives amyloid," he said.
He cited the " lipid invasion model" as a way of understanding brain lipid dysregulation. This hypothesis posits that AD is driven by external lipids that enter the brain as a result of damage to the blood-brain barrier (BBB).
"Cholesterol in the brain and cholesterol in the periphery — meaning, in the rest of the body, outside the brain — are separate," Hansen explained. "The brain produces its own cholesterol and keeps tight control of it."
-Scott Hansen, PhD, associate professor, Department of Molecular Medicine, Herbert Wertheim UF Scripps Institute for Biomedical Innovation and Technology, Florida
SO, Exercise, Balanced diet, andP rudent supplementation is vital. Here's why:
Our arterial blood supply to brain delivers essential oxygen, glucose, other nutrients including lipids, amino acids, mineral salts and vitamins. Our cardiac and brain venous system removes waste products including CO2. Our brain lymph drainage system is critical to maintaining proper brain homeostasis.
Our cardiac/brain artery delivery of nutrients, and venous removal of respiratory wastes, is determined and limited by the proper function of the rest of our cardiovascular system.
How to know? Answer. We need to try to maintain for our entire life a VO2 max of at least 50 millitres of oxygen per kg of body mass per minute.